Multimodal Neuroimaging with Simultaneous fMRI and EEG

2021 ◽  
pp. 1-23
Author(s):  
Govinda R. Poudel ◽  
Richard D. Jones
Keyword(s):  
Multimodal Neuroimaging

scholarly journals In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yo-Han Joo ◽  
Yun-Kwan Kim ◽  
In-Gyu Choi ◽  
Hyeon-Jin Kim ◽  
Young-Don Son ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Glucose Metabolism ◽  
Cerebral Glucose Metabolism ◽  
Functional Coupling ◽  
Resonance Spectroscopy ◽  
Acute Administration ◽  
Multimodal Neuroimaging ◽  
Mk 801 ◽  
Genetic Ablation ◽  
Neuroimaging Study

Abstract Background Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiology of psychiatric disorders such as schizophrenia. We aimed to establish the functional interaction between mGluR5 and NMDA receptors in brain of mice with genetic ablation of the mGluR5. Methods We first measured the brain glutamate levels with magnetic resonance spectroscopy (MRS) in mGluR5 knockout (KO) and wild-type (WT) mice. Then, we assessed brain glucose metabolism with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography before and after the acute administration of an NMDA antagonist, MK-801 (0.5 mg/kg), in the same mGluR5 KO and WT mice. Results Between-group comparisons showed no significant differences in [18F]FDG standardized uptake values (SUVs) in brain of mGluR5 KO and WT mice at baseline, but widespread reductions in mGluR5 KO mice compared to WT mice after MK-801 administration (p < 0.05). The baseline glutamate levels did not differ significantly between the two groups. However, there were significant negative correlations between baseline prefrontal glutamate levels and regional [18F]FDG SUVs in mGluR5 KO mice (p < 0.05), but no such correlations in WT mice. Fisher’s Z-transformation analysis revealed significant between-group differences in these correlations (p < 0.05). Conclusions This is the first multimodal neuroimaging study in mGluR5 KO mice and the first report on the association between cerebral glucose metabolism and glutamate levels in living rodents. The results indicate that mGluR5 KO mice respond to NMDA antagonism with reduced cerebral glucose metabolism, suggesting that mGluR5 transmission normally moderates the net effects of NMDA receptor antagonism on neuronal activity. The negative correlation between glutamate levels and glucose metabolism in mGluR5 KO mice at baseline may suggest an unmasking of an inhibitory component of the glutamatergic regulation of neuronal energy metabolism.

Multimodal Neuroimaging of Sex Differences in Cognitively Impaired Patients on the Alzheimer's Continuum: Greater Tau-PET Retention in Females

2021 ◽  
Author(s):  
Lauren Edwards ◽  
Renaud La Joie ◽  
Leonardo Iaccarino ◽  
Amelia Strom ◽  
Suzanne L Baker ◽  
...  
Keyword(s):  
Sex Differences ◽  
Cognitively Impaired ◽  
Multimodal Neuroimaging ◽  
Tau Pet

scholarly journals General overview on the merits of multimodal neuroimaging data fusion

NeuroImage ◽  
2014 ◽  
Vol 102 ◽  
pp. 3-10 ◽  
Author(s):  
Kâmil Uludağ ◽  
Alard Roebroeck
Keyword(s):  
Data Fusion ◽  
Multimodal Neuroimaging ◽  
General Overview ◽  
Neuroimaging Data

Visuospatial processing in early Alzheimer’s disease: A multimodal neuroimaging study

Cortex ◽  
2015 ◽  
Vol 64 ◽  
pp. 394-406 ◽  
Author(s):  
Heidi I.L. Jacobs ◽  
Ed H.B.M. Gronenschild ◽  
Elisabeth A.T. Evers ◽  
Inez H.G.B. Ramakers ◽  
Paul A.M. Hofman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Multimodal Neuroimaging ◽  
Visuospatial Processing ◽  
Neuroimaging Study ◽  
Early Alzheimer’S Disease

A multimodal neuroimaging approach to non lesional frontal lobe epilepsy

2021 ◽  
Vol 429 ◽  
pp. 117689
Author(s):  
Pio Zoleo ◽  
Francesco Fortunato ◽  
Alessia Giugno ◽  
Enrico Fratto ◽  
Vincenzina Rubino ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Frontal Lobe Epilepsy ◽  
Multimodal Neuroimaging

scholarly journals A Knowledge Representation and Reasoning System for Multimodal Neuroimaging Studies

2017 ◽  
Vol 20 (59) ◽  
pp. 42 ◽  
Author(s):  
Ana Coelho ◽  
Paulo Marques ◽  
Ricardo Magalhães ◽  
Nuno Sousa ◽  
José Neves ◽  
...  
Keyword(s):  
Knowledge Representation And Reasoning ◽  
Case Based Reasoning ◽  
Multimodal Neuroimaging ◽  
Multimodal Data ◽  
Reasoning System ◽  
Reasoning Systems ◽  
Major Interest ◽  
Neuroimaging Data ◽  
And Function ◽  
Undiagnosed Diseases

Multimodal neuroimaging analyses are of major interest for both research and clinical practice, enabling the combined evaluation of the structure and function of the human brain. These analyses generate large volumes of data and consequently increase the amount of possibly useful information. Indeed, BrainArchive was developed in order to organize, maintain and share this complex array of neuroimaging data. It stores all the information available for each participant/patient, being dynamic by nature. Notably, the application of reasoning systems to this multimodal data has the potential to provide tools for the identification of undiagnosed diseases. As a matter of fact, in this work we explore how Artificial Intelligence techniques for decision support work, namely Case-Based Reasoning (CBR) that may be used to achieve such endeavour. Particularly, it is proposed a reasoning system that uses the information stored in BrainArchive as past knowledge for the identification of individuals that are at risk of contracting some brain disease.

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