Hyperconnection and hyperperfusion of overlapping brain regions in patients with menstrual-related migraine: a multimodal neuroimaging study

2021 ◽  
Author(s):  
Xinyu Li ◽  
Ahsan Khan ◽  
Yingying Li ◽  
Diansen Chen ◽  
Jing Yang ◽  
...  
Keyword(s):  
Brain Regions ◽  
Multimodal Neuroimaging ◽  
Neuroimaging Study

scholarly journals In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yo-Han Joo ◽  
Yun-Kwan Kim ◽  
In-Gyu Choi ◽  
Hyeon-Jin Kim ◽  
Young-Don Son ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Glucose Metabolism ◽  
Cerebral Glucose Metabolism ◽  
Functional Coupling ◽  
Resonance Spectroscopy ◽  
Acute Administration ◽  
Multimodal Neuroimaging ◽  
Mk 801 ◽  
Genetic Ablation ◽  
Neuroimaging Study

Abstract Background Perturbed functional coupling between the metabotropic glutamate receptor-5 (mGluR5) and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory glutamatergic neurotransmission may contribute to the pathophysiology of psychiatric disorders such as schizophrenia. We aimed to establish the functional interaction between mGluR5 and NMDA receptors in brain of mice with genetic ablation of the mGluR5. Methods We first measured the brain glutamate levels with magnetic resonance spectroscopy (MRS) in mGluR5 knockout (KO) and wild-type (WT) mice. Then, we assessed brain glucose metabolism with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography before and after the acute administration of an NMDA antagonist, MK-801 (0.5 mg/kg), in the same mGluR5 KO and WT mice. Results Between-group comparisons showed no significant differences in [18F]FDG standardized uptake values (SUVs) in brain of mGluR5 KO and WT mice at baseline, but widespread reductions in mGluR5 KO mice compared to WT mice after MK-801 administration (p < 0.05). The baseline glutamate levels did not differ significantly between the two groups. However, there were significant negative correlations between baseline prefrontal glutamate levels and regional [18F]FDG SUVs in mGluR5 KO mice (p < 0.05), but no such correlations in WT mice. Fisher’s Z-transformation analysis revealed significant between-group differences in these correlations (p < 0.05). Conclusions This is the first multimodal neuroimaging study in mGluR5 KO mice and the first report on the association between cerebral glucose metabolism and glutamate levels in living rodents. The results indicate that mGluR5 KO mice respond to NMDA antagonism with reduced cerebral glucose metabolism, suggesting that mGluR5 transmission normally moderates the net effects of NMDA receptor antagonism on neuronal activity. The negative correlation between glutamate levels and glucose metabolism in mGluR5 KO mice at baseline may suggest an unmasking of an inhibitory component of the glutamatergic regulation of neuronal energy metabolism.

scholarly journals An fMRI study of scientists with a Ph.D. in physics confronted with naive ideas in science

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Geneviève Allaire-Duquette ◽  
Lorie-Marlène Brault Foisy ◽  
Patrice Potvin ◽  
Martin Riopel ◽  
Marilyne Larose ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Conceptual Understanding ◽  
Matched Control ◽  
Brain Regions ◽  
Scientific Training ◽  
Frontal Brain ◽  
Fmri Study ◽  
Lower Accuracy ◽  
Neuroimaging Study ◽  
Scientific Value

AbstractA central challenge in developing conceptual understanding in science is overcoming naive ideas that contradict the content of science curricula. Neuroimaging studies reveal that high school and university students activate frontal brain areas associated with inhibitory control to overcome naive ideas in science, probably because they persist despite scientific training. However, no neuroimaging study has yet explored how persistent naive ideas in science are. Here, we report brain activations of 25 scientists with a Ph.D. in physics assessing the scientific value of naive ideas in science. Results show that scientists are slower and have lower accuracy when judging the scientific value of naive ideas compared to matched control ideas. fMRI data reveals that a network of frontal brain regions is more activated when judging naive ideas. Results suggest that naive ideas are likely to persist, even after completing a Ph.D. Advanced experts may still rely on high order executive functions like inhibitory control to overcome naive ideas when the context requires it.

Visuospatial processing in early Alzheimer’s disease: A multimodal neuroimaging study

Cortex ◽  
2015 ◽  
Vol 64 ◽  
pp. 394-406 ◽  
Author(s):  
Heidi I.L. Jacobs ◽  
Ed H.B.M. Gronenschild ◽  
Elisabeth A.T. Evers ◽  
Inez H.G.B. Ramakers ◽  
Paul A.M. Hofman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Multimodal Neuroimaging ◽  
Visuospatial Processing ◽  
Neuroimaging Study ◽  
Early Alzheimer’S Disease

scholarly journals Understanding the neural basis of episodic amnesia in logopenic progressive aphasia: A multimodal neuroimaging study

Cortex ◽  
2020 ◽  
Vol 125 ◽  
pp. 272-287 ◽  
Author(s):  
Siddharth Ramanan ◽  
Lars Marstaller ◽  
John R. Hodges ◽  
Olivier Piguet ◽  
Muireann Irish
Keyword(s):  
Neural Basis ◽  
Multimodal Neuroimaging ◽  
Progressive Aphasia ◽  
Neuroimaging Study

scholarly journals O2-07-05: OBSTRUCTIVE SLEEP APNEA SEVERITY AND BRAIN INTEGRITY IN AGEING: A MULTIMODAL NEUROIMAGING STUDY

2019 ◽  
Vol 15 ◽  
pp. P552-P553
Author(s):  
Claire Andre ◽  
Stéphane Rehel ◽  
Elizabeth Kuhn ◽  
Brigitte Landeau ◽  
Robin de Flores ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Multimodal Neuroimaging ◽  
Obstructive Sleep Apnea Severity ◽  
Obstructive Sleep ◽  
Neuroimaging Study

Serotonin-1A receptor binding is positively associated with gray matter volume — A multimodal neuroimaging study combining PET and structural MRI

NeuroImage ◽  
2012 ◽  
Vol 63 (3) ◽  
pp. 1091-1098 ◽  
Author(s):  
Christoph Kraus ◽  
Andreas Hahn ◽  
Markus Savli ◽  
Georg S. Kranz ◽  
Pia Baldinger ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Structural Mri ◽  
Serotonin 1A Receptor ◽  
Multimodal Neuroimaging ◽  
Matter Volume ◽  
Neuroimaging Study

scholarly journals A multimodal neuroimaging study of a case of crossed nonfluent/agrammatic primary progressive aphasia

2015 ◽  
Vol 262 (10) ◽  
pp. 2336-2345 ◽  
Author(s):  
Edoardo G. Spinelli ◽  
Francesca Caso ◽  
Federica Agosta ◽  
Giuseppe Gambina ◽  
Giuseppe Magnani ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Multimodal Neuroimaging ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Neuroimaging Study

scholarly journals Abnormalities of Dorsolateral Prefrontal Function in Women With Premenstrual Dysphoric Disorder: A Multimodal Neuroimaging Study

2013 ◽  
Vol 170 (3) ◽  
pp. 305-314 ◽  
Author(s):  
Erica B. Baller ◽  
Shau-Ming Wei ◽  
Philip D. Kohn ◽  
David R. Rubinow ◽  
Gabriela Alarcón ◽  
...  
Keyword(s):  
Premenstrual Dysphoric Disorder ◽  
Multimodal Neuroimaging ◽  
Prefrontal Function ◽  
Dorsolateral Prefrontal ◽  
Neuroimaging Study
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