Ensemble Learning via Multimodal Multiobjective Differential Evolution and Feature Selection

Author(s):  
Jie Wang ◽  
Bo Wang ◽  
Jing Liang ◽  
Kunjie Yu ◽  
Caitong Yue ◽  
...  
2020 ◽  
Vol 8 (5) ◽  
pp. 3081-3087

Now-a-days an important threat to women over global manner is Breast-Cancer, which is the major disease cause drastic affection to female especially. Identification of Breast Cancer over earlier stages is must to save one's life and the significant affection range of Breast-Cancer is drastically improved day by day due to the improper food-habits, pollution-level and improper-life style as well as genetic-issues also. The main cause of this disease is the arising of breast-ample over the ‘breast-area, which develops the cancer to women in several cases. If the detection or prediction of such masses over earlier stage will helps to women to get more survival ratio as well as this leads a proportion to researchers to make an systematic process to detect such diseases on initial stages by using intelligent prediction methodologies with high accuracy rates. In this paper, the proposed system handles several stages of processing to make sure the prediction accuracy, such steps are as follows: Data acquisition, Feature vector formation by normalization, Feature Selection by using Differential Evolution based selection methodology, Classification using Subspace Ensemble Learning and different Performance Measures. By using these strategies the entire work assures the proposed system is perfect to predict or identify the breast cancer benign/malignant stages more accurately compare to the classical Margin-Based Feature-Selection process. Compared to the classical biopsy methodology, a systematic diagnosis attains more impact due to its prediction accuracy. This proposed system is powered by a powerful approach called Differential-Evolution Feature’-Selection (“DEFS”) with the association of Subspace Ensemble Learning Classification principle, which provides highest accuracy and prediction rates compare to the classical methodologies. This proposed paper assures effective and robust mining strategies in Breast Cancer identification/prediction as well as efficient decision-making norms. The proposed outcome proves the good accuracy and resulting levels by means of Precision-Recall, Sensitivity and Specificity, True Positive/True Negative, False Positive/False Negative, Accuracy and Time Consumption.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Li-Hsin Cheng ◽  
Te-Cheng Hsu ◽  
Che Lin

AbstractBreast cancer is a heterogeneous disease. To guide proper treatment decisions for each patient, robust prognostic biomarkers, which allow reliable prognosis prediction, are necessary. Gene feature selection based on microarray data is an approach to discover potential biomarkers systematically. However, standard pure-statistical feature selection approaches often fail to incorporate prior biological knowledge and select genes that lack biological insights. Besides, due to the high dimensionality and low sample size properties of microarray data, selecting robust gene features is an intrinsically challenging problem. We hence combined systems biology feature selection with ensemble learning in this study, aiming to select genes with biological insights and robust prognostic predictive power. Moreover, to capture breast cancer's complex molecular processes, we adopted a multi-gene approach to predict the prognosis status using deep learning classifiers. We found that all ensemble approaches could improve feature selection robustness, wherein the hybrid ensemble approach led to the most robust result. Among all prognosis prediction models, the bimodal deep neural network (DNN) achieved the highest test performance, further verified by survival analysis. In summary, this study demonstrated the potential of combining ensemble learning and bimodal DNN in guiding precision medicine.


Sign in / Sign up

Export Citation Format

Share Document