Introduction for Stem Cell–Based Therapy for Neurodegenerative Diseases

2020 ◽  
pp. 1-8
Author(s):  
Fabin Han ◽  
Paul Lu
Keyword(s):  
Stem Cell ◽  
Neurodegenerative Diseases ◽  
Cell Based Therapy

scholarly journals Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2663
Author(s):  
Rodrigo Pinheiro Araldi ◽  
Fernanda D’Amelio ◽  
Hugo Vigerelli ◽  
Thatiana Correa de Melo ◽  
Irina Kerkis
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disorders ◽  
Therapeutic Approach ◽  
Rapid Rise ◽  
Cell Based Therapy ◽  
New Treatments ◽  
Medical Advances ◽  
Minimal Information

The aging population has contributed to the rapid rise in the global incidence of neurodegenerative diseases. Despite the medical advances, there are no effective treatments for these disorders. Therefore, there is an urgent need for new treatments for these diseases. In this sense, cell therapy has been recognized as the best candidate for treating incurable diseases, such as neurodegenerative disorders. However, the therapeutic use of these cells can be limited by several factors. Thus, there has been a rediscovery that extracellular vesicles, including exosomes, can be alternatively explored in the treatment of these diseases, overcoming the limits of cell-based therapy. In this sense, this review aims to revisit all areas from biology, including biogenesis and the content of exosomes, to biotechnology, proposing the minimal information required to isolate, characterize, and study the content of these vesicles for scientific and/or clinical purposes.

scholarly journals Stem cell sources and therapeutic approaches for central nervous system and neural retinal disorders

2008 ◽  
Vol 24 (3-4) ◽  
pp. E11 ◽  
Author(s):  
Diana Yu ◽  
Gabriel A. Silva
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Neurodegenerative Diseases ◽  
The Body ◽  
Cns Disorders ◽  
Cell Based Therapy ◽  
Therapeutic Benefits ◽  
Made In

✓ In the past decades, stem cell biology has made a profound impact on our views of mammalian development as well as opened new avenues in regenerative medicine. The potential of stem cells to differentiate into various cell types of the body is the principal reason they are being explored in treatments for diseases in which there may be dysfunctional cells and/or loss of healthy cells due to disease. In addition, other properties are unique to stem cells; their endogenous trophic support, ability to home to sites of pathological entities, and stability in culture, which allows genetic manipulation, are also being utilized to formulate stem cell–based therapy for central nervous system (CNS) disorders. In this review, the authors will review key characteristics of embryonic and somatic (adult) stem cells, consider therapeutic strategies employed in stem cell therapy, and discuss the recent advances made in stem cell–based therapy for a number of progressive neurodegenerative diseases in the CNS as well as neuronal degeneration secondary to other abnormalities and injuries. Although a great deal of progress has been made in our knowledge of stem cells and their utility in treating CNS disorders, much still needs to be elucidated regarding the biology of the stem cells and the pathogenesis of targeted CNS diseases to maximize therapeutic benefits. Nonetheless, stem cells present tremendous promise in the treatment of a variety of neurodegenerative diseases.

Stem Cell-Based Therapy in Human Neurodegenerative Diseases

2015 ◽  
Vol 12 (SEMAR) ◽  
pp. 19-24
Author(s):  
Esmaeel Ebrahimi ◽  
Seyed Ahmad Hosseini ◽  
Saeed Shirali ◽  
Mostafa Cheshmposh
Keyword(s):  
Stem Cell ◽  
Neurodegenerative Diseases ◽  
Cell Based Therapy

scholarly journals Regenerative Medicine for Neurological Disorders

2010 ◽  
Vol 10 ◽  
pp. 470-489 ◽  
Author(s):  
Dong-Hyuk Park ◽  
David J. Eve ◽  
Yong-Gu Chung ◽  
Paul R. Sanberg
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Neurodegenerative Diseases ◽  
Cell Biology ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Epithelial Stem Cells ◽  
Cell Based Therapy ◽  
Cord Injury

The annual meeting of the American Society for Neural Therapy and Repair (ASNTR) has always introduced us to top-notch and up-to-date approaches for regenerative medicine related to neuroscience, ranging from stem cell–based therapy to novel drugs. The 16th ASNTR meeting focused on a variety of different topics, including the unknown pathogenesis or mechanisms of specific neurodegenerative diseases, stem cell biology, and development of novel alternative medicines or devices. Newly developed stem cells, such as amniotic epithelial stem cells and induced pluripotent stem cells, as well as well-known traditional stem cells, such as neural, embryonic, bone marrow mesenchymal, and human umbilical cord blood–derived stem cells, were reported. A number of commercialized stem cells were also covered at this meeting. Fetal neural tissues, such as ventral mesencephalon, striatum, and Schwann cells, were investigated for neurodegenerative diseases or spinal cord injury. A number of studies focused on novel methods for drug monitoring or graft tracking, and combination therapy with stem cells and medicine, such as cytokines or trophic factors. Finally, the National Institutes of Health guidelines for human stem cell research, clinical trials of commercialized stem cells without larger animal testing, and prohibition of medical tourism were big controversial issues that led to heated discussion.

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