Importance of Mitochondrial Quality Control in Parkinson’s Disease: The Potential Interplay of Mitochondrial Unfolded Protein Response and Mitophagy

2021 ◽  
pp. 103-131
Author(s):  
Yew Mun Lee ◽  
Dongxue Hu ◽  
Yih-Cherng Liou
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Quality Control ◽  
Unfolded Protein Response ◽  
Mitochondrial Quality Control ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

scholarly journals At the heart of mitochondrial quality control: many roads to the top

2021 ◽  
Author(s):  
Roberta A. Gottlieb ◽  
Honit Piplani ◽  
Jon Sin ◽  
Savannah Sawaged ◽  
Syed M. Hamid ◽  
...  
Keyword(s):  
Quality Control ◽  
Unfolded Protein Response ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Dynamics ◽  
Mitochondrial Quality Control ◽  
Unfolded Protein ◽  
Selective Elimination ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

AbstractMitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.

Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease

2019 ◽  
Vol 111 (6) ◽  
pp. 161-168 ◽  
Author(s):  
Alexis Martinez ◽  
Nelida Lopez ◽  
Constanza Gonzalez ◽  
Claudio Hetz
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

scholarly journals Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons

2017 ◽  
Vol 26 (22) ◽  
pp. 4441-4450 ◽  
Author(s):  
Sabrina M Heman-Ackah ◽  
Raquel Manzano ◽  
Jeroen JM Hoozemans ◽  
Wiep Scheper ◽  
Rowan Flynn ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Unfolded Protein Response ◽  
Alpha Synuclein ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response

Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson’s disease

2011 ◽  
Vol 116 (4) ◽  
pp. 588-605 ◽  
Author(s):  
Arianna Bellucci ◽  
Laura Navarria ◽  
Michela Zaltieri ◽  
Elisa Falarti ◽  
Serena Bodei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Unfolded Protein Response ◽  
Experimental Models ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response
Sign in / Sign up

Export Citation Format

Share Document