Reactive Oxygen Species, Glucose Metabolism, and Lipid Metabolism

2021 ◽  
pp. 213-235
Author(s):  
Ying Yang ◽  
Yue Wu ◽  
Xiao-Dong Sun ◽  
Yuanyuan Zhang
2014 ◽  
Vol 20 (4) ◽  
pp. 557-573 ◽  
Author(s):  
Anne Drougard ◽  
Thibaut Duparc ◽  
Xavier Brenachot ◽  
Lionel Carneiro ◽  
Alexandra Gouazé ◽  
...  

2020 ◽  
Vol 147 ◽  
pp. 104358
Author(s):  
Xiaocui Ma ◽  
Haiyan Wei ◽  
Yaodong Zhang ◽  
You Duan ◽  
Wanting Zhang ◽  
...  

Neuroreport ◽  
2020 ◽  
Vol 31 (3) ◽  
pp. 226-234 ◽  
Author(s):  
Binchu Xu ◽  
Qingping Zhang ◽  
Xinlin Luo ◽  
Xinjie Ning ◽  
Juncheng Luo ◽  
...  

Author(s):  
Sun Park ◽  
Mi Jin Lee ◽  
Seung Jun Lee ◽  
Su Jin Yun ◽  
Ji-Young Jang ◽  
...  

2018 ◽  
Vol 1698 ◽  
pp. 54-61 ◽  
Author(s):  
Anderson V. Catarina ◽  
Carolina Luft ◽  
Samuel Greggio ◽  
Gianina T. Venturin ◽  
Fernanda Ferreira ◽  
...  

2010 ◽  
Vol 48 (7) ◽  
pp. 953-960 ◽  
Author(s):  
Carlos Hermano da Justa Pinheiro ◽  
Leonardo R. Silveira ◽  
Renato Tadeu Nachbar ◽  
Kaio Fernando Vitzel ◽  
Rui Curi

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1951 ◽  
Author(s):  
Tao Luo ◽  
Jinliang Gao ◽  
Na Lin ◽  
Jinke Wang

Leukemia is a common and lethal disease. In recent years, iron-based nanomedicines have been developed as a new ferroptosis inducer to leukemia. However, the cytotoxicity of iron nanoparticles to leukemia cells at the transcriptomic level remains unclear. This study investigated the effects of two kinds of iron nanoparticles, 2,3-Dimercaptosuccinic acid (DMSA)-coated Fe3O4 nanoparticles (FeNPs) as a reactive oxygen species (ROS) inducer and Prussian blue nanoparticles (PBNPs) as an ROS scavenger, on the transcriptomic profiles of two leukemia cells (KG1a and HL60) by RNA-Seq. As a result, 470 and 1690 differentially expressed genes (DEGs) were identified in the FeNP-treated HL60 and KG1a cells, respectively, and 2008 and 2504 DEGs were found in the PBNP-treated HL60 and KG1a cells, respectively. Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24). The gene ontology revealed that the mineral absorption pathway was significantly regulated by PBNPs in two cells, whereas the lipid metabolism and HIF-1 signaling pathways were significantly regulated by FeNPs in two cells. This study established the gene signatures of two kinds of nanoparticles in two leukemia cells, which revealed the main biological processes regulated by the two kinds of iron nanoparticles. These data shed new insights into the cytotoxicity of iron nanoparticles that differently regulate ROS in leukemia cells with variant stemness.


2017 ◽  
Vol 633 ◽  
pp. 93-102 ◽  
Author(s):  
Xiao-Yan Pang ◽  
Suya Wang ◽  
Michael J. Jurczak ◽  
Gerald I. Shulman ◽  
Alexander R. Moise

2015 ◽  
Vol 89 (8) ◽  
pp. 1209-1226 ◽  
Author(s):  
Dania C. Liemburg-Apers ◽  
Peter H. G. M. Willems ◽  
Werner J. H. Koopman ◽  
Sander Grefte

Sign in / Sign up

Export Citation Format

Share Document