A Traffic Network Congestion Diffusion Model Based on Gene Regulation Mechanism

2019 ◽  
pp. 563-572
Author(s):  
Xiangwei Wu ◽  
Ning Huang ◽  
Kan Xu
Keyword(s):  
Gene Regulation ◽  
Diffusion Model ◽  
Regulation Mechanism ◽  
Traffic Network ◽  
Network Congestion ◽  
Model Based

Fourth order diffusion model based edge map extraction of infrared breast images

2019 ◽  
Vol 19 (2) ◽  
pp. 499-506
Author(s):  
J. Thamil Selvi ◽  
G. Kavitha ◽  
C.M. Sujatha
Keyword(s):  
Diffusion Model ◽  
Fourth Order ◽  
Model Based

scholarly journals Network Congestion Diffusion Model Considering Congestion Distribution Information

IEEE Access ◽  
2019 ◽  
Vol 7 ◽  
pp. 102064-102072 ◽  
Author(s):  
Guoyi Wen ◽  
Ning Huang ◽  
Chunlin Wang
Keyword(s):  
Diffusion Model ◽  
Network Congestion

scholarly journals Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinyi Wan ◽  
Filipe Pinto ◽  
Luyang Yu ◽  
Baojun Wang
Keyword(s):  
Gene Expression ◽  
Gene Regulation ◽  
Protein Binding ◽  
Gene Networks ◽  
Dynamic Range ◽  
Gene Expression Regulation ◽  
Single Layer ◽  
Regulation Mechanism ◽  
Gene Circuits ◽  
Synthetic Dna

AbstractVersatile tools for gene expression regulation are vital for engineering gene networks of increasing scales and complexity with bespoke responses. Here, we investigate and repurpose a ubiquitous, indirect gene regulation mechanism from nature, which uses decoy protein-binding DNA sites, named DNA sponge, to modulate target gene expression in Escherichia coli. We show that synthetic DNA sponges can be designed to reshape the response profiles of gene circuits, lending multifaceted tuning capacities including reducing basal leakage by >20-fold, increasing system output amplitude by >130-fold and dynamic range by >70-fold, and mitigating host growth inhibition by >20%. Further, multi-layer DNA sponges for decoying multiple regulatory proteins provide an additive tuning effect on the responses of layered circuits compared to single-layer sponges. Our work shows synthetic DNA sponges offer a simple yet generalizable route to systematically engineer the performance of synthetic gene circuits, expanding the current toolkit for gene regulation with broad potential applications.

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