Identification and Age-dependent Increase of Platelet Biased Human Hematopoietic Stem Cells

Hematopoietic stem cells (HSC) reconstitute multi-lineage human hematopoiesis after clinical bone marrow transplantation and are the cells-of-origin of hematological malignancies. Though HSC provide multi-lineage engraftment, individual murine HSCs are lineage-biased and contribute unequally to blood cell lineages. Now, by combining xenografting of molecularly barcoded adult human bone marrow (BM) HSCs and high-throughput single cell RNA sequencing we demonstrate that human individual BM HSCs are also functionally and transcriptionally lineage biased. Specifically, we identify platelet-biased and multi-lineage human HSCs. Quantitative comparison of transcriptomes from single HSCs from young, and aged, BM show that both the proportion of platelet-biased HSCs, and their level of transcriptional platelet priming, increases with age. Therefore, platelet-biased HSCs, as well as their increased prevalence and elevated transcriptional platelet priming during ageing, are conserved between human and murine hematopoiesis.

“Shocked at my Levity”

Ezra Pound’s humor promotes unorthodox intimacies between readers and writers. His portraits in The Pisan Cantos catch Henry James and James Joyce laughing, emphasizing their human peculiarities and Pound’s personal knowledge of them. These scenes suggest how unsatisfactory he finds traditional notions of poetic immortality. Instead, his portraits of jesting writers make literary texts contain the artist as both heroic figure and human individual, doing the work of high art and personal interaction simultaneously. Pound loves the Romantic figure of the poet-hero, but his laughter emphasizes that artist’s fallible humanity, and highlights modernism’s concern with creating accurate models of imaginative sympathy. As Pound’s laughter becomes more intimate, however, it is also more troubling: humor in The Cantos seeks to enlist his reader not just in his poem but in his hierarchical vision of art and his fascist politics.

THE EFFECTIVENESS OF CHARACTER VALUE INTERNALIZATION THROUGH NGUSABHA SAMBAH TOWARDS BALI AGA CULTURE RESILIENCE TENGANAN PEGRINGSINGAN VILLAGE, MANGGIS DISCRICT, KARANGASEM REGENCY

<p class="p2">Every human individual is always in the process of forming his character, because a character is formed starting from the family, school, and environment. Formally, the formation of human character is formed consciously and systematically in developing self-potential. Tenganan Pegringsingan Traditional Village has a religious tradition which is considered as a place for internalizing character values which is devoted as a form of cultural resilience in the Tenganan Pegringsingan Traditional Village, which is held annually and every three years for <em>muran </em>which is marked with <em>sasih kapat </em>twice in one year which is right on <em>sasih kalima </em>according to the calendar system of the Tenganan Pegringsingan Traditional Village is called <em>Ngusaba Sambah</em>. The results of this scientific paper using a qualitative research with an ethnographic approach.<span class="Apple-converted-space"> </span></p>

Surpassing our genes: The subversive post-human message of 'Gattaca'

The movie Gattaca is often referenced in public debates about the societal dangers of human gene editing. In the public imaginary, its message is clear: the dystopian future it portrays stands as a warning against the societal acceptance of genetic perfectionism and genetic discrimination. This article argues that such a reading misses a deeper message of this cinematic text. Rather than offer a bioethics lesson against the use of genetics to make better human babies, in our opinion, the film actually argues that such genetic tampering is unlikely to succeed, but that the genetic engineering of a superior post-human individual is both possible and desirable.

Mental Budgeting dan Motivasi Terhadap Pengelolaan Keuangan Individu

Budgeting cannot be separated from personality and by itself arises from the human individual—people who will make and run the budget. With the budget, financial management will be better. This research was conducted to find out the influence of mental budgeting and motivation on the financial management of individuals. This research was conducted through a questionnaire survey distributed to polytechnic students in 2021 who had taken budget and financial management courses. The sample from this study was 108 samples using Slovin and random sampling techniques. It was then continued with hypothesis testing using multiple linear regressions. The results of this study state that mental budgeting has a positive effect on individuals' financial management, and motivations positively affect personal financial management.

Who was buried with Nestor’s Cup? Macroscopic and microscopic analyses of the cremated remains from Tomb 168 (second half of the 8th century BCE, Pithekoussai, Ischia Island, Italy)

Cremation 168 from the second half of the 8th century BCE (Pithekoussai’s necropolis, Ischia Island, Italy), better known as the Tomb of Nestor’s Cup, is widely considered as one of the most intriguing discoveries in the Mediterranean Pre-Classic archaeology. A drinking cup, from which the Tomb’s name derives, bears one of the earliest surviving examples of written Greek, representing the oldest Homeric poetry ever recovered. According to previous osteological analyses, the Cup is associated with the cremated remains of a juvenile, aged approximately 10–14 years at death. Since then, a vast body of literature has attempted to explain the unique association between the exceptionality of the grave good complex, the symposiac and erotic evocation of the Nestor’s Cup inscription with the young age of the individual buried with it. This paper reconsiders previous assessments of the remains by combining gross morphology with qualitative histology and histomorphometric analyses of the burnt bone fragments. This work reveals the commingled nature of the bone assemblage, identifying for the first time, more than one human individual mixed with faunal remains. These outcomes dramatically change previous reconstructions of the cremation deposit, rewriting the answer to the question: who was buried with Nestor’s Cup?.

Aquinas and “I”

A reified self (“the self,” “the I”) is absent from medieval European thought. Nonetheless, medieval Scholastic authors do have something to say about the subjective dimension of human experience that the later concept of the reified self was intended to address. Focusing on Thomas Aquinas (1225–1274), this chapter examines the two key themes of self-consciousness and personal identity, in order to explore how Aquinas developed his notion of the human individual as a subject of experience who can speak about herself as “I,” in the first person. This episode illustrates a key moment in the development of medieval European thought on selfhood, in the confluence of philosophical and theological traditions from the Greek, Islamic, and Latin worlds.

To the question of variations in the arteries of the lower leg in connection with a case of bilateral absence a. tibialis post

The bloodstream in the first periods of the life of a human individual is an extremely unstable formation.

BOTANICAL MYTHS: FAKE NEWS OF THE CONTEMPORARY WORLD

The myths take many forms depending on the cultures in which we find them; however, their function is always to explain natural phenomena that occur in their surroundings. As observed throughout human history, it is an inherent condition for the human species to believe in the metaphysical and to use their individual and introspective thinking as a way to achieve their dreams and goals, something that works as a responsible 'driving force' in many cases, for governing and inspiring the human individual. Additionally, populations or part of communities that obtain their livelihood and/or subsistence directly from agricultural activity spontaneously express a greater willingness to believe in the 'infallible' agroforestry myths, which explain the possible botanical phenomena. In light of this, our present study lists the main physiological bases refuting different botanical myths based on evidence proven in original articles. Furthermore, our phenomenological approach was carried out in an eclectic way in the field of botany and is not linked to any specific authority or philosophical school. Finally, we explore and integrate different, mutually compatible approaches to provide the reader with a global understanding of the 'infallibility' of botanical myths.

Kairos in Innovation Policy

A kairos constellation designates a temporarily existing opportunity for a group of actors to take advantage of a coincidence of favourable circumstances in order to realise a shared target. Starting from the observation that kairos constellations are ubiquitous in human individual and social life, the research question of this paper is how the Triple Helix and the wider innovation policy research literature deals with such constellations. The authors develop a conceptual framework for kairos constellations and discuss empirical evidence that kairos constellations have been scrutinized in innovation research literature. Then, the concept is applied to an example from the Triple Helix – based cluster policy. The key message of this paper is that Triple Helix researchers should systematically study kairos constellations because they are a critical force in the evolution of innovations systems as well as business firms, which has not yet been systematically examined.