In this paper, we study and construct a set of Witten indexes for K, where K is any n-dimensional knot in Sn+2 and n is any natural number. We form a supersymmetric quantum system for K by, first, constructing a set of functional spaces (spaces of fermionic (resp. bosonic) states) and a set of operators (supersymmetric infinitesimal transformations) in an explicit way. Our Witten indexes are topological invariant and they are nonzero in general. These indexes are zero if K is equivalent to a trivial knot. Besides, our Witten indexes restrict to the Alexander polynomials of n-knots, and one of the Alexander polynomials of K is nontrivial if any of the Witten indexes is nonzero. Our indexes are related to homology with twisted coefficients. Roughly speaking, these indexes posseses path-integral representation in the usual manner of supersymmetric theory.