Molecular Markers in Gestational Trophoblastic Diseases

2021 ◽  
pp. 37-52
Author(s):  
Vidya Rao ◽  
Santosh Menon ◽  
Bharat Rekhi ◽  
Kedar Deodhar
Keyword(s):  
Molecular Markers ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

Guideline No. 408: Management of Gestational Trophoblastic Diseases

2021 ◽  
Vol 43 (1) ◽  
pp. 91-105.e1
Author(s):  
Lua Eiriksson ◽  
Erin Dean ◽  
Alexandra Sebastianelli ◽  
Shannon Salvador ◽  
Robyn Comeau ◽  
...  
Keyword(s):  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

scholarly journals Imbalance between matrix metalloproteinases and their tissue inhibitors in preeclampsia and gestational trophoblastic diseases

Reproduction ◽  
2016 ◽  
Vol 152 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Beenish Rahat ◽  
Renuka Sharma ◽  
Rashmi Bagga ◽  
Abid Hamid ◽  
Jyotdeep Kaur
Keyword(s):  
Matrix Metalloproteinases ◽  
Differential Expression ◽  
Normal Pregnancy ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Tissue Inhibitors ◽  
Trophoblastic Diseases ◽  
Histone Trimethylation ◽  
Gestational Trophoblastic Diseases ◽  
Normal Gestation ◽  
Cancerous Cells

The invasion cascade exhibited by placental trophoblasts and cancerous cells bears many similarities, and it is attributed to extracellular matrix degradation mediated by matrix metalloproteinases (MMPs). Although proper and controlled invasion by trophoblasts into the maternal uterus is an essential requirement for maintenance of normal pregnancy, any abnormality in this phenomenon results in the development of invasion-related disorders such as gestational trophoblastic diseases (GTDs) and preeclampsia. We studied the epigenetic basis of differential expression of two placental MMPs (MMP2andMMP9) and tissue inhibitors of metalloproteinases (TIMP2andTIMP1) during normal gestation and invasion-related disorders, i.e., preeclampsia and GTDs. Our study suggests the association of H3K9/27me3 with differential expression of these MMPs and their inhibitors, which regulate the placental invasion during normal pregnancy, whereas no role of CpG methylation was observed in the differential expression of MMPs/TIMPs. Further, development of GTDs was associated with abnormally higher expression of these MMPs and lower levels of their inhibitors, whereas the reverse trends were observed for MMPs and their TIMPs in case of preeclampsia, in association with abnormal changes in H3K9/27me3. These results suggest the involvement of higher levels of MMPs in an aggressive invasive behavior depicted by GTDs, whereas lower levels of these MMPs in shallow and poor invasive phenotype associated with preeclampsia. Thus, our study shows the significance of a proper balance regulated by histone trimethylation between differential expression of MMPs and their TIMPs for maintaining normal pregnancy and its deregulation as a contributing factor for pathogenesis of invasive disorders during pregnancy.

scholarly journals DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases

Oncogene ◽  
1998 ◽  
Vol 17 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Vilmos Fulop ◽  
Cristiano V Colitti ◽  
David Genest ◽  
Ross S Berkowitz ◽  
Gary K Yiu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

scholarly journals Study of gestational trophoblastic diseases at a tertiary care hospital in India

2018 ◽  
Vol 7 (4) ◽  
pp. 1622
Author(s):  
Ramalingappa C. Antaratani ◽  
Shruthi M.
Keyword(s):  
Hydatidiform Mole ◽  
Local Population ◽  
Tertiary Care ◽  
Spontaneous Remission ◽  
Standard Of Care ◽  
Gestational Trophoblastic Disease ◽  
Care Hospital ◽  
Case Record ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

Background: Gestational trophoblastic disease refers to the heterogeneous group of interrelated lesions that arises from abnormal proliferation of placental trophoblasts. GTNs are among the rare human tumours that can be cured even in the presence of widespread dissemination. Although GTNs commonly follow a molar pregnancy, they can occur after any gestational event, including induced or spontaneous abortion, ectopic pregnancy, or term pregnancy. The study was conducted to know the incidence of different types of gestational trophoblastic diseases in the local population and the percentage of people ultimately requiring chemotherapy.Methods: The retrospective analysis of case record of 124 women with a diagnosis of GTD admitted to Karnataka Institute of Medical Sciences Hubli between November 2008 to November 2017.Results: A total of 124 cases of GTD were reviewed. Hydatidiform mole was diagnosed in 91 patients; of those experienced spontaneous remission after evacuation. 04 patients had persistent gestational trophoblastic Neoplasia and 13 cases of invasive mole (GTN) 1 case of epitheloid trophoblastic tumors and 15 cases of choriocarcinoma 99 (80%) had low-risk GTN, 25 (20%) had high-risk GTN.Conclusions: Hydatidiform mole was found to be the most common form of gestational trophoblastic diseases. Majority of the cases got cured by simple surgical evacuation. During the course of our study some rare cases of gestational trophoblastic diseases were noted. Patients’ compliance for serial follow up is a highly challenging task in developing countries. Registration of women with GTD represents a minimum standard of care.

The Diagnostic Value of p27 in Comparison to p57 in Differentiation Between Different Gestational Trophoblastic Diseases

2013 ◽  
Vol 32 (6) ◽  
pp. 395-411 ◽  
Author(s):  
Asmaa Abdou ◽  
Mona Kandil ◽  
Moshira Abd El-Wahed ◽  
Mohammed Shabaan ◽  
Mona El-Sharkawy
Keyword(s):  
Diagnostic Value ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases
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