The toxicity of mercuric chloride and methylmercuric chloride to Fundulus heteroclitus embryos in relation to exposure conditions

1982 ◽  
Vol 7 (3) ◽  
pp. 277-284 ◽  
Author(s):  
John R. Sharp ◽  
Jerry M. Neff
Keyword(s):  
Mercuric Chloride ◽  
Fundulus Heteroclitus ◽  
Methylmercuric Chloride ◽  
Exposure Conditions

Differential effects of methylmercuric chloride and mercuric chloride on the L-glutamate and potassium evoked release of [3H]dopamine from mouse striatal slices

1986 ◽  
Vol 64 (5) ◽  
pp. 656-660 ◽  
Author(s):  
S. J. McKay ◽  
J. N. Reynolds ◽  
W. J. Racz
Keyword(s):  
Calcium Channel ◽  
Glutamate Receptor ◽  
Mercuric Chloride ◽  
Neurotransmitter Release ◽  
Mechanisms Of Action ◽  
Major Site ◽  
Striatal Slices ◽  
Differential Effects ◽  
Methylmercuric Chloride ◽  
Site Of Action

The effects of CH3HgCl and HgCl2 on the evoked release of 3H from mouse striatal slices prelabelled with [3H]dopamine have been examined. CH3HgCl (10 μM) was observed to increase the L-glutamate-evoked release of [3H]dopamine, while HgCl2 (10 μM) had no effect. In contrast, CH3HgCl at concentrations up to 100 μM had no effect on the 25 mM K+-stimulated release of [3H]dopamine, whereas HgCl2 (100 μM) significantly reduced the 25 mM K+-stimulated release of [3H]dopamine. Thus CH3HgCl and HgCl2 have differential effects on the L-glutamate- and K+-stimulated release of [3H]dopamine from mouse striatal slices, suggesting that these compounds may have different sites and (or) mechanisms of action in altering neurotransmitter release. It is suggested that CH3HgCl may act predominantly at intracellular sites or at the level of the L-glutamate receptor, whereas the major site of action of HgCl2 may be the voltage-operated calcium channel.

Fine structure of the fish chloride cell associated with both acute and chronic exposure to mercury

1978 ◽  
Vol 36 (2) ◽  
pp. 452-453
Author(s):  
Stephen J. Koepp ◽  
NAncy C. Dorato
Keyword(s):  
Fine Structure ◽  
Mercuric Chloride ◽  
Chronic Exposure ◽  
Fundulus Heteroclitus ◽  
Osmium Tetroxide ◽  
Chloride Cell ◽  
Estuarine Fish ◽  
Environmental Concentration ◽  
Acute And Chronic Exposure ◽  
Cell Versus

Prior cytopathologic studies have demonstrated the sensitivity of fish respiratory and transporting epithelia to mercurials. Despite a well-documented role in extrarenal osmoregulation, the specific involvement of the teleost chloride cell in mercurialism has not been reported. This paper describes the response of this primary filament cell versus acute and chronic exposure to mercuric chloride. The estuarine fish (Fundulus heteroclitus) was used as the target organism. Locally-collected male mummichogs (3. 5-4. 5 g) were acclimated in the laboratory two weeks prior to use. For acute contaminations fish were incubated in artificial seawater containing one of three concentrations of mercury (0. 25, 0. 75 and 1. 50 mg/1) at 20 C and 20 o/oo salinity. In a similar manner other fish were exposed for 30 days to an environmental concentration of toxicant (0. 05 mg/1). Gill tissues of survivors at 12, 36 and 96 hours (acute) and 30 days (chronic) plus controls were fixed for three hours in cold 4% phosphate-buffered glutaraldehyde, postfixed in 1% osmium tetroxide and subsequently embedded in Epon 812.

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