An electrophysiological study of the action of methylmercuric chloride and mercuric chloride on the sciatic nerve-sartorius muscle preparation of the frog

1976 ◽  
Vol 37 (2) ◽  
pp. 339-348 ◽  
Author(s):  
Ming Shing Juang
Keyword(s):  
Sciatic Nerve ◽  
Mercuric Chloride ◽  
Electrophysiological Study ◽  
Sartorius Muscle ◽  
Muscle Preparation ◽  
Methylmercuric Chloride

scholarly journals ACTION OF POTASSIUM AND NARCOTICS ON RECTIFICATION IN NERVE AND MUSCLE

1944 ◽  
Vol 28 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Rita Guttman
Keyword(s):  
Plasma Membrane ◽  
Sciatic Nerve ◽  
Rana Pipiens ◽  
Current Flow ◽  
Barium Chloride ◽  
Resting Potential ◽  
Sartorius Muscle ◽  
Potassium Ions ◽  
Excess Calcium ◽  
Simultaneous Decrease

Electrical rectification was demonstrated in whole sartorius muscle and sciatic nerve of Rana pipiens and also in the single giant nerve fiber of the northern squid, Ommastrephes illecibrossus. It is probably a property of the plasma membrane. Rectification decreases reversibly under the influence of increased concentrations of the potassium ion and with chloroform, veratrine sulfate and isoamyl carbamate. No effect was found with lack of calcium, excess calcium, or barium chloride. Decrease in rectification is invariably accompanied by simultaneous decrease in resting potential. A proposed explanation of the mechanism of rectification is discussed. Rectification in a living membrane, viz. a change in resistance with change in direction of current flow, may possibly be explained in terms of a change in the concentration of potassium ions in the membrane.

Differential effects of methylmercuric chloride and mercuric chloride on the L-glutamate and potassium evoked release of [3H]dopamine from mouse striatal slices

1986 ◽  
Vol 64 (5) ◽  
pp. 656-660 ◽  
Author(s):  
S. J. McKay ◽  
J. N. Reynolds ◽  
W. J. Racz
Keyword(s):  
Calcium Channel ◽  
Glutamate Receptor ◽  
Mercuric Chloride ◽  
Neurotransmitter Release ◽  
Mechanisms Of Action ◽  
Major Site ◽  
Striatal Slices ◽  
Differential Effects ◽  
Methylmercuric Chloride ◽  
Site Of Action

The effects of CH3HgCl and HgCl2 on the evoked release of 3H from mouse striatal slices prelabelled with [3H]dopamine have been examined. CH3HgCl (10 μM) was observed to increase the L-glutamate-evoked release of [3H]dopamine, while HgCl2 (10 μM) had no effect. In contrast, CH3HgCl at concentrations up to 100 μM had no effect on the 25 mM K+-stimulated release of [3H]dopamine, whereas HgCl2 (100 μM) significantly reduced the 25 mM K+-stimulated release of [3H]dopamine. Thus CH3HgCl and HgCl2 have differential effects on the L-glutamate- and K+-stimulated release of [3H]dopamine from mouse striatal slices, suggesting that these compounds may have different sites and (or) mechanisms of action in altering neurotransmitter release. It is suggested that CH3HgCl may act predominantly at intracellular sites or at the level of the L-glutamate receptor, whereas the major site of action of HgCl2 may be the voltage-operated calcium channel.

PRELIMINARY STUDY FOR PREVENTION OF NEURAL ADHESION USING AN ABSORBABLE OXIDISED REGENERATED CELLULOSE SHEET

Hand Surgery ◽  
2002 ◽  
Vol 07 (01) ◽  
pp. 11-14 ◽  
Author(s):  
Kazuo Ikeda ◽  
Daisuke Yamauchi ◽  
Katsuro Tomita
Keyword(s):  
Sciatic Nerve ◽  
Histological Study ◽  
Electrophysiological Study ◽  
Additional Treatment ◽  
Regenerated Cellulose ◽  
Significant Difference ◽  
Group A ◽  
Preliminary Study ◽  
Group B ◽  
Nerve Surgery

The purpose of this study was to clarify the effect of an absorbable oxidised regenerated cellulose sheet (AORCS) for prevention of neural adhesion. Rabbit sciatic nerve was exposed at the middle of the thigh and the neural bed was coagulated by a bipolar coagulator to establish an adhesion model. Coagulation only was Group A (n = 8), coagulation and wrapping the sciatic nerve with an AORCS was Group B (n = 8), and an intact nerve was Group C (n = 16). Six weeks later, each group was estimated. Adhesion between the nerve and neural bed, and intraneural fibrosis were seen in Group A. However, there was little adhesion and fibrosis in Group B. Although the electrophysiological study showed a small significant difference, AORCS clearly prevented the adhesion in the histological study. Hence, AORCS might be useful as an additional treatment during nerve surgery.

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