Open-loop control of specific growth rate in fed-batch cultures of recombinant E.coli

1993 ◽  
Vol 7 (12) ◽  
pp. 889-894 ◽  
Author(s):  
M. E. Gregory ◽  
C. Turner
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Specific Growth ◽  
Open Loop ◽  
Open Loop Control ◽  
Fed Batch ◽  
Loop Control ◽  
Batch Cultures ◽  
Recombinant E.Coli

Influence of specific growth rate over the secretory expression of recombinant potato carboxypeptidase inhibitor in fed-batch cultures of Escherichia coli

2010 ◽  
Vol 45 (8) ◽  
pp. 1334-1341 ◽  
Author(s):  
Juan-Miguel Puertas ◽  
Jordi Ruiz ◽  
Mónica Rodríguez de la Vega ◽  
Julia Lorenzo ◽  
Glòria Caminal ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Growth Rate ◽  
Specific Growth Rate ◽  
Specific Growth ◽  
Fed Batch ◽  
Secretory Expression ◽  
Batch Cultures ◽  
Carboxypeptidase Inhibitor

scholarly journals Control of Specific Growth Rate in Fed-Batch Bioprocesses: Novel Controller Design for Improved Noise Management

Processes ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 679 ◽  
Author(s):  
Yann Brignoli ◽  
Brian Freeland ◽  
David Cunningham ◽  
Michal Dabros
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Real Time ◽  
Specific Growth ◽  
Controller Design ◽  
Control Variable ◽  
Biomass Concentration ◽  
Growth Dynamics ◽  
Fed Batch ◽  
Batch Cultures

Accurate control of the specific growth rate (µ) of microorganisms is dependent on the ability to quantify the evolution of biomass reliably in real time. Biomass concentration can be monitored online using various tools and methods, but the obtained signal is often very noisy and unstable, leading to inaccuracies in the estimation of μ. Furthermore, controlling the growth rate is challenging as the process evolves nonlinearly and is subject to unpredictable disturbances originating from the culture’s metabolism. In this work, a novel feedforward-feedback controller logic is presented to counter the problem of noise and oscillations in the control variable and to address the exponential growth dynamics more effectively. The controller was tested on fed-batch cultures of Kluyveromyces marxianus, during which μ was estimated in real time from online biomass concentration measurements obtained with dielectric spectroscopy. It is shown that the specific growth rate can be maintained at different setpoint values with an average root mean square control error of 23 ± 6%.

An algorithm for operating a fed-batch fermentor at optimum specific-growth rate

1989 ◽  
Vol 33 (1) ◽  
pp. 115-125 ◽  
Author(s):  
Pramod Agrawal ◽  
George Koshy ◽  
Michael Ramseier
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Specific Growth ◽  
Fed Batch

scholarly journals Specific Growth Rate control in Fed-Batch Bakers' Yeast Fermentation

1993 ◽  
Vol 26 (2) ◽  
pp. 185-188
Author(s):  
M. Keulers ◽  
L. Ariaans ◽  
M. Giuseppin ◽  
R. Soeterboek
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Rate Control ◽  
Specific Growth ◽  
Yeast Fermentation ◽  
Fed Batch ◽  
Growth Rate Control

Automated fed-batch culture of Kluyveromyces fragilis based on a novel method for on-line estimation of cell specific growth rate

2001 ◽  
Vol 9 (3) ◽  
pp. 221-231 ◽  
Author(s):  
Zairossani M. Nor ◽  
Melih I. Tamer ◽  
Jeno M. Scharer ◽  
Murray Moo-Young ◽  
Eric J. Jervis
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Batch Culture ◽  
Specific Growth ◽  
Fed Batch ◽  
Kluyveromyces Fragilis ◽  
On Line ◽  
Novel Method ◽  
Fed Batch Culture
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