The AMPA antagonists NBQX and GYKI 52466 do not counteract neuroleptic-induced catalepsy

1994 ◽  
Vol 349 (1) ◽  
Author(s):  
Beate Zadow ◽  
WernerJ. Schmidt
Keyword(s):  
Gyki 52466 ◽  
Ampa Antagonists

Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: Effects of GYKI 52466 and its novel analogues

2008 ◽  
Vol 198 (2) ◽  
pp. 231-241 ◽  
Author(s):  
Gábor L. Kapus ◽  
István Gacsályi ◽  
Miklos Vegh ◽  
Hajnalka Kompagne ◽  
Endre Hegedűs ◽  
...  
Keyword(s):  
Ampa Receptors ◽  
Gyki 52466

Evidence that GYKI 52466, a novel non-NMDA antagonist enhances the decay of kainate-induced current in cultured chicken cortical neurons

1994 ◽  
Vol 77 (2) ◽  
pp. 257-263 ◽  
Author(s):  
O. Osipenko ◽  
A. Mike ◽  
A. Gyevai ◽  
E.S. Vizi
Keyword(s):  
Cortical Neurons ◽  
Nmda Antagonist ◽  
Induced Current ◽  
Gyki 52466

Differential Impact of Miniature Synaptic Potentials on the Soma and Dendrites of Pyramidal Neurons In Vivo

1997 ◽  
Vol 78 (3) ◽  
pp. 1735-1739 ◽  
Author(s):  
Denis Paré ◽  
Elen Lebel ◽  
Eric J. Lang
Keyword(s):  
Pyramidal Neurons ◽  
Pyramidal Cells ◽  
Input Resistance ◽  
Differential Impact ◽  
Synaptic Potentials ◽  
Ampa Antagonists ◽  
Intact Brain ◽  
The Impact

Paré, Denis, Elen LeBel, and Eric J. Lang. Differential impact of miniature synaptic potentials on the somata and dendrites of pyramidal neurons in vivo. J. Neurophysiol. 78: 1735–1739, 1997. We studied the impact of transmitter release resistant to tetrodotoxin (TTX) in morphologically identified neocortical pyramidal neurons recorded intracellularly in barbiturate-anesthetized cats. It was observed that TTX-resistant release occurs in pyramidal neurons in vivo and at much higher frequencies than was previously reported in vitro. Further, in agreement with previous findings indicating that GABAergic and glutamatergic synapses are differentially distributed in the somata and dendrites of pyramidal cells, we found that most miniature synaptic potentials were sensitive to γ-aminobutyric acid-A (GABAA) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists in presumed somatic and dendritic impalements, respectively. Pharmacological blockage of spontaneous synaptic events produced large increases in input resistance that were more important in dendritic (≈50%) than somatic (≈10%) impalements. These findings imply that in the intact brain, pyramidal neurons are submitted to an intense spike-independent synaptic bombardment that decreases the space constant of the cells. These results should be taken into account when extrapolating in vitro findings to intact brains.

GYKI 52466, an inhibitor of spinal reflexes is a potent quisqualate antagonist

Amino Acids ◽  
1990 ◽  
pp. 538-546 ◽  
Author(s):  
Istvàn Tarnawa ◽  
Ingemar Engberg ◽  
John A. Flatman
Keyword(s):  
Spinal Reflexes ◽  
Gyki 52466

scholarly journals Synergistic protection of NMDA and AMPA antagonists against ischemic neuronal damage (2): Studies on in vivo cerebral ischemia model.

1996 ◽  
Vol 71 ◽  
pp. 179
Author(s):  
Tsuyoshi Kihara ◽  
Mitsuru Yasui ◽  
Masami Eigyo ◽  
Kazuo Kawasaki
Keyword(s):  
Cerebral Ischemia ◽  
Neuronal Damage ◽  
Ampa Antagonists

scholarly journals AMPA antagonists inhibit the extracellular signal regulated kinase pathway and suppress lung cancer growth

2007 ◽  
Vol 6 (12) ◽  
pp. 1908-1915 ◽  
Author(s):  
Andrzej Stepulak ◽  
Marco Sifringer ◽  
Wojciech Rzeski ◽  
Katja Brocke ◽  
Alexander Gratopp ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Growth ◽  
Extracellular Signal Regulated Kinase ◽  
Ampa Antagonists ◽  
Extracellular Signal ◽  
Kinase Pathway

Novel Quinolinone-Phosphonic Acid AMPA Antagonists Devoid of Nephrotoxicity.

ChemInform ◽  
2003 ◽  
Vol 34 (8) ◽  
Author(s):  
Alex A. Cordi ◽  
Patrice Desos ◽  
Elisabeth Ruano ◽  
Hashim Al-Badri ◽  
Claude Fugier ◽  
...  
Keyword(s):  
Phosphonic Acid ◽  
Ampa Antagonists
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