ChemInform Abstract: Synthesis and Potent Anticonvulsant Activities of 4-Oxo-imidazo[1,2-a]indeno[1,2-e]pyrazin-8- and -9-carboxylic (Acetic) Acid AMPA Antagonists.

The analgesic, anti-inflammatory, anticonvulsant and CNS activities of the ethanolic extract of Butea monosperma roots were examined. The extract produced no significant inhibition of abdominal constrictions caused by acetic acid. It showed significant inhibition of the earlyphase of formalin-induced pain, also reduced the weight of granuloma induced by a cotton pellet. Moreover, the extract caused a moderate inhibition of ear swelling in mice caused by croton oil. In pentobarbital induced sleeping time test the extract slightly reduced the onset and increased the duration of sleeping. Therefore, Butea monosperma showed analgesic, antiinflammatory, mild anticonvulsant activities as well as sedative effect on CNS.Jahangirnagar University J. Biol. Sci. 4(1): 9-18, 2015 (June)

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Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents

ISRN Organic Chemistry ◽

10.1155/2013/587054 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 12

Author(s):

Mohamed Alswah ◽

Adel Ghiaty ◽

Ahmed El-Morsy ◽

Kamal El-Gamal

Keyword(s):

Acetic Acid ◽

Elemental Analysis ◽

Acid Hydrazide ◽

Biological Evaluation ◽

Mass Spectral Data ◽

Mass Spectral ◽

H Nmr ◽

Quinoxaline Derivatives ◽

Anticonvulsant Activities ◽

Synthesis And Biological Evaluation

2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities.

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Ectodesmata as Revealed By Freeze-Etch Preparations of Plant Epidermal Cell Walls

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072782 ◽

1973 ◽

Vol 31 ◽

pp. 468-469

Author(s):

N.C. Lyon ◽

W. C. Mueller

Keyword(s):

Electron Microscopy ◽

Acetic Acid ◽

Nitric Acid ◽

Oxalic Acid ◽

Light Microscopy ◽

Epidermal Cell ◽

Cell Walls ◽

Plant Viruses ◽

Plant Leaves ◽

Thin Sections

Schumacher and Halbsguth first demonstrated ectodesmata as pores or channels in the epidermal cell walls in haustoria of Cuscuta odorata L. by light microscopy in tissues fixed in a sublimate fixative (30% ethyl alcohol, 30 ml:glacial acetic acid, 10 ml: 65% nitric acid, 1 ml: 40% formaldehyde, 5 ml: oxalic acid, 2 g: mecuric chloride to saturation 2-3 g). Other workers have published electron micrographs of structures transversing the outer epidermal cell in thin sections of plant leaves that have been interpreted as ectodesmata. Such structures are evident following treatment with Hg++ or Ag+ salts and are only rarely observed by electron microscopy. If ectodesmata exist without such treatment, and are not artefacts, they would afford natural pathways of entry for applied foliar solutions and plant viruses.

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