Islet cell neogenesis in the pancreas

1996 ◽  
Vol 427 (6) ◽  
Author(s):  
L. Bouwens ◽  
G. Kl�ppel
Keyword(s):  
Islet Cell ◽  
Islet Cell Neogenesis

Enhanced islet cell neogenesis and endocrine cell differentiation are pathognomonic with congenital hyperinsulinism in infancy

2016 ◽  
Author(s):  
Elise Hardwick ◽  
Bing Han ◽  
Maria Salomon-Estebanez ◽  
Raja Padidela ◽  
Mars Skae ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Endocrine Cell ◽  
Islet Cell ◽  
Congenital Hyperinsulinism ◽  
Islet Cell Neogenesis

Ductular Cell Proliferation in Islet Cell Neogenesis Induced by Incomplete Ligation of the Pancreatic Duct in Dogs

Surgery Today ◽  
2004 ◽  
Vol 34 (7) ◽  
Author(s):  
Masaki Nagaya ◽  
Sunao Kubota ◽  
Akiko Isogai ◽  
Mamoru Tadokoro ◽  
Katsuya Akashi
Keyword(s):  
Cell Proliferation ◽  
Pancreatic Duct ◽  
Islet Cell ◽  
Islet Cell Neogenesis ◽  
Ductular Cell

Ulcerogenic Tumors of the Pancreas

1968 ◽  
Vol 26 ◽  
pp. 186-187
Author(s):  
J. C. Garancis ◽  
J. F. Kuzma ◽  
S. D. Wilson ◽  
E. H. Ellison
Keyword(s):  
Endoplasmic Reticulum ◽  
Tumor Cells ◽  
Islet Cell ◽  
Disease Process ◽  
Central Core ◽  
Islet Cell Tumors ◽  
Opaque Zone ◽  
Granular Form ◽  
Zollinger Ellison Syndrome

It has been proposed that a gastrin-like hormone elaborated by non-beta islet tumors of the pancreas may be responsible for a fulminating ulcer diathesis. Subsequently, a potent gastric secretagogue was isolated from ulcerogenic tumors of the pancreas. This disease process is known now as “Zollinger-Ellison syndrome”.In our studies of two cases of Zollinger-Ellison syndrome, pancreatic lesions were identified as alpha islet cell tumors (Fig. 1). Tumor cells were fairly uniform. The sizes of the alpha granules were not significantly different, but their number and distribution varied greatly from one cell to another. Each granule consisted of a round, highly dense central core, separated from the limiting membrane by an opaque zone. The granular form of the endoplasmic reticulum was particularly prominent. Numerous mitochondria, round or elongated, were dispersed throughout the cytoplasm. Individual or clusters of lysosomes were observed in the majority of cells.

Islet Cell Transplant Frees Patient From Insulin

2005 ◽  
Vol 38 (6) ◽  
pp. 15
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Islet Cell ◽  
Cell Transplant

Living Donor Islet Cell Transplant Called a Success

2005 ◽  
Vol 35 (6) ◽  
pp. 12
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Islet Cell ◽  
Living Donor ◽  
Cell Transplant

Fetuin-A impairs maturation of pig neonatal islet cell clusters

2018 ◽  
Author(s):  
F Gerst ◽  
AK Fritz ◽  
E Lorza Gil ◽  
E Wolf ◽  
HU Häring ◽  
...  
Keyword(s):  
Islet Cell ◽  
Fetuin A ◽  
Cell Clusters

THERAPIE EINES METASTASIERENDEN INSELZELLTUMORS MIT STREPTOZOTOCIN

1971 ◽  
Vol 67 (2) ◽  
pp. 405-416 ◽  
Author(s):  
E. Nieschlag ◽  
H. Wombacher ◽  
F. J. Kroeger ◽  
L.V. Habighorst
Keyword(s):  
Liver Metastases ◽  
Blood Sugar ◽  
Mechanism Of Action ◽  
Islet Cell ◽  
Plasma Insulin ◽  
Severe Hypoglycaemia ◽  
Islet Cells ◽  
Intravenous Injections ◽  
High Affinity ◽  
Methyl Nitrosourea

A patient with a metastazing functional islet cell tumour suffering from severe hypoglycaemia was treated with streptozotocin. Four intravenous injections of 1.5 g streptozotocin each were administered in 4 to 6 days intervals. After the 4th injection there were no further episodes of hypoglycaemia, parenteral glucose administration could be stopped and blood sugar and plasma insulin, showing concentrations of up to 405 μU/ml before treatment, reached normal levels. The tumours in the pancreas disappeared and the liver metastases decreased in size and number as judged by arteriography. A hypothesis for the mechanism of action of streptozotocin is proposed. The glucose moiety is considered to facilitate a high affinity to the islet cells whereas the N-methyl-nitrosourea residue serves the active antitumour part of the molecule.

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