The segregation of mitochondrial genes in yeast

1975 ◽  
Vol 139 (4) ◽  
pp. 329-339 ◽  
Author(s):  
Jean L. Forster ◽  
Roger A. Kleese
Keyword(s):  
Mitochondrial Genes

GPS2 Regulates Mitochondria Biogenesis via Mitochondria Retrograde Signaling and Chromatin Remodeling of Nuclear-Encoded Mitochondrial Genes

2018 ◽  
Author(s):  
Maria Dafne Cardamone ◽  
Bogdan Tanasa ◽  
Carly Cedarquist ◽  
Jiawen Huang ◽  
Kiana Mahdaviani ◽  
...  
Keyword(s):  
Chromatin Remodeling ◽  
Mitochondrial Genes ◽  
Retrograde Signaling ◽  
Mitochondria Biogenesis

scholarly journals Neurodegenerative disorders associated with genes of mitochondria

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Vaibhav S. Marde ◽  
Prerna L. Tiwari ◽  
Nitu L. Wankhede ◽  
Brijesh G. Taksande ◽  
Aman B. Upaganlawar ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Mitochondrial Dysfunction ◽  
Neurodegenerative Disorders ◽  
Friedreich Ataxia ◽  
Mitochondrial Genes ◽  
Disease Development ◽  
Main Text ◽  
Functional Studies ◽  
Dominant Part ◽  
Causative Link

Abstract Background Over the last decade, aggregating evidences suggested that there is a causative link between mutation in gene associated with mitochondrial dysfunction and development of several neurodegenerative disorders. Main text Recent structural and functional studies associated with mitochondrial genes have shown that mitochondrial abnormalities possibly lead to mitochondrial dysfunction. Several studies on animal models of neurodegenerative diseases and mitochondrial genes have provided compelling evidence that mitochondria is involved in the initiation as well as progression of diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and Friedreich ataxia (FA). Conclusion In this mini-review, we have discussed the different etiologic and pathogenesis connected with the mitochondrial dysfunction and relevant neurodegenerative diseases that underlie the dominant part of mitochondrial genes in the disease development and its progress.

scholarly journals Nuclear Gene Dosage Effects Upon the Expression of Maize Mitochondrial Genes

Genetics ◽  
2001 ◽  
Vol 157 (4) ◽  
pp. 1711-1721
Author(s):  
Donald L Auger ◽  
Kathleen J Newton ◽  
James A Birchler
Keyword(s):  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Gene Dosage ◽  
Nuclear Gene ◽  
Eukaryotic Cell ◽  
Mitochondrial Genes ◽  
Northern Analysis ◽  
Α Subunit ◽  
Dosage Effects ◽  
A Genome

Abstract Each mitochondrion possesses a genome that encodes some of its own components. The nucleus encodes most of the mitochondrial proteins, including the polymerases and factors that regulate the expression of mitochondrial genes. Little is known about the number or location of these nuclear factors. B-A translocations were used to create dosage series for 14 different chromosome arms in maize plants with normal cytoplasm. The presence of one or more regulatory factors on a chromosome arm was indicated when variation of its dosage resulted in the alteration in the amount of a mitochondrial transcript. We used quantitative Northern analysis to assay the transcript levels of three mitochondrially encoded components of the cytochrome c oxidase complex (cox1, cox2, and cox3). Data for a nuclearly encoded component (cox5b) and for two mitochondrial genes that are unrelated to cytochrome c oxidase, ATP synthase α-subunit and 18S rRNA, were also determined. Two tissues, embryo and endosperm, were compared and most effects were found to be tissue specific. Significantly, the array of dosage effects upon mitochondrial genes was similar to what had been previously found for nuclear genes. These results support the concept that although mitochondrial genes are prokaryotic in origin, their regulation has been extensively integrated into the eukaryotic cell.

scholarly journals Regulatory interactions between mitochondrial genes. I. Genetic and biochemical characterization of some mutant types affecting apocytochrome b and cytochrome oxidase

1979 ◽  
Vol 254 (7) ◽  
pp. 2471-2479
Author(s):  
N.J. Alexander ◽  
R.D. Vincent ◽  
P.S. Perlman ◽  
D.H. Miller ◽  
D.K. Hanson ◽  
...  
Keyword(s):  
Cytochrome Oxidase ◽  
Biochemical Characterization ◽  
Mitochondrial Genes ◽  
Regulatory Interactions ◽  
Apocytochrome B

scholarly journals Loss of coordinated expression between ribosomal and mitochondrial genes revealed by comprehensive characterization of a large family with a rare Mendelian disorder

Genomics ◽  
2021 ◽  
Author(s):  
Brendan Panici ◽  
Hosei Nakajima ◽  
Colleen M. Carlston ◽  
Hakan Ozadam ◽  
Can Cenik ◽  
...  
Keyword(s):  
Large Family ◽  
Mitochondrial Genes ◽  
Mendelian Disorder ◽  
Coordinated Expression ◽  
Comprehensive Characterization

scholarly journals Resolving Phylogenetic Relationships within Passeriformes Based on Mitochondrial Genes and Inferring the Evolution of Their Mitogenomes in Terms of Duplications

2019 ◽  
Vol 11 (10) ◽  
pp. 2824-2849 ◽  
Author(s):  
Paweł Mackiewicz ◽  
Adam Dawid Urantówka ◽  
Aleksandra Kroczak ◽  
Dorota Mackiewicz
Keyword(s):  
Phylogenetic Analyses ◽  
Mitochondrial Genes ◽  
The Other ◽  
Phylogenetic Position ◽  
Evolutionary Relationships ◽  
Mitochondrial Genomes ◽  
Ancestral State ◽  
Phylogenetic Information ◽  
Long Time ◽  
Tree Topologies

Abstract Mitochondrial genes are placed on one molecule, which implies that they should carry consistent phylogenetic information. Following this advantage, we present a well-supported phylogeny based on mitochondrial genomes from almost 300 representatives of Passeriformes, the most numerous and differentiated Aves order. The analyses resolved the phylogenetic position of paraphyletic Basal and Transitional Oscines. Passerida occurred divided into two groups, one containing Paroidea and Sylvioidea, whereas the other, Passeroidea and Muscicapoidea. Analyses of mitogenomes showed four types of rearrangements including a duplicated control region (CR) with adjacent genes. Mapping the presence and absence of duplications onto the phylogenetic tree revealed that the duplication was the ancestral state for passerines and was maintained in early diverged lineages. Next, the duplication could be lost and occurred independently at least four times according to the most parsimonious scenario. In some lineages, two CR copies have been inherited from an ancient duplication and highly diverged, whereas in others, the second copy became similar to the first one due to concerted evolution. The second CR copies accumulated over twice as many substitutions as the first ones. However, the second CRs were not completely eliminated and were retained for a long time, which suggests that both regions can fulfill an important role in mitogenomes. Phylogenetic analyses based on CR sequences subjected to the complex evolution can produce tree topologies inconsistent with real evolutionary relationships between species. Passerines with two CRs showed a higher metabolic rate in relation to their body mass.

scholarly journals Systematic analysis of mitochondrial genes associated with hearing loss in the Japanese population: dHPLC reveals a new candidate mutation

2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Hideki Mutai ◽  
Hiroko Kouike ◽  
Eiko Teruya ◽  
Ikuko Takahashi-Kodomari ◽  
Hiroki Kakishima ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Japanese Population ◽  
Mitochondrial Genes ◽  
Systematic Analysis ◽  
Candidate Mutation

scholarly journals A Molecular Phylogeny of Bivalve Mollusks: Ancient Radiations and Divergences as Revealed by Mitochondrial Genes

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27147 ◽  
Author(s):  
Federico Plazzi ◽  
Alessandro Ceregato ◽  
Marco Taviani ◽  
Marco Passamonti
Keyword(s):  
Molecular Phylogeny ◽  
Mitochondrial Genes ◽  
Bivalve Mollusks
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