GPS2 Regulates Mitochondria Biogenesis via Mitochondria Retrograde Signaling and Chromatin Remodeling of Nuclear-Encoded Mitochondrial Genes

SSRN Electronic Journal ◽

10.2139/ssrn.3155593 ◽

2018 ◽

Author(s):

Maria Dafne Cardamone ◽

Bogdan Tanasa ◽

Carly Cedarquist ◽

Jiawen Huang ◽

Kiana Mahdaviani ◽

...

Keyword(s):

Chromatin Remodeling ◽

Mitochondrial Genes ◽

Retrograde Signaling ◽

Mitochondria Biogenesis

GPS2 regulates mitochondria biogenesis via mitochondrial retrograde signaling and chromatin remodeling of nuclear-encoded mitochondrial genes

10.1101/162297 ◽

2017 ◽

Author(s):

Maria Dafne Cardamone ◽

Bogdan Tanasa ◽

Carly Cederquist ◽

Jiawen Huang ◽

Kiana Mahdaviani ◽

...

Keyword(s):

Rna Polymerase Ii ◽

Transcriptional Activation ◽

Mitochondrial Gene ◽

Nuclear Gene ◽

Mitochondrial Genes ◽

Retrograde Signaling ◽

Gene Promoters ◽

Brown Adipose ◽

Mitochondrial Functions ◽

Mitochondrial Retrograde Signaling

SummaryAs most of the mitochondrial proteome is encoded in the nucleus, mitochondrial functions critically depend on nuclear gene expression and bidirectional mito-nuclear communication. However, mitochondria-to-nucleus communication pathways are incompletely understood. Here, we identify G-Protein Pathway Suppressor 2 (GPS2) as a mediator of mitochondrial retrograde signaling and a key transcriptional activator of nuclear-encoded mitochondrial genes in mammals. GPS2 regulated translocation from mitochondria to nucleus is essential for the transcriptional activation of the nuclear stress response to mitochondrial depolarization and for supporting basal mitochondrial biogenesis in differentiating adipocytes and in brown adipose tissue from mice. In the nucleus, GPS2 recruitment to target gene promoters regulates histone H3K9 demethylation and RNA Polymerase II (POL2) activation through inhibition of Ubc13-mediated ubiquitination. Together, these findings reveal an unexpected layer of regulation of mitochondrial gene transcription as they uncover a novel mitochondria-nuclear communication pathway.

Chromatin remodeling and initiation of DNA replication

Frontiers in Bioscience ◽

10.2741/a666 ◽

2001 ◽

Vol 6 (3) ◽

pp. d1048-1053 ◽

Cited By ~ 4

Author(s):

Rong Li

Keyword(s):

Dna Replication ◽

Chromatin Remodeling ◽

Initiation Of Dna Replication

Faculty Opinions recommendation of Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1005012.58805 ◽

2002 ◽

Author(s):

Steven Henikoff

Keyword(s):

Chromatin Remodeling ◽

Gene Activation

Faculty Opinions recommendation of Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1005012.58156 ◽

2002 ◽

Author(s):

Michael Meisterernst

Keyword(s):

Chromatin Remodeling ◽

Gene Activation

Faculty Opinions recommendation of Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1011647.185169 ◽

2003 ◽

Author(s):

Dinah Singer

Keyword(s):

Chromatin Remodeling ◽

Inositol Polyphosphates ◽

Chromatin Remodeling Complexes

Faculty Opinions recommendation of A role for chromatin remodeling in transcriptional termination by RNA polymerase II.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012027.183916 ◽

2003 ◽

Author(s):

Peter B Becker

Keyword(s):

Rna Polymerase ◽

Rna Polymerase Ii ◽

Chromatin Remodeling ◽

Transcriptional Termination

Faculty Opinions recommendation of The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1014780.194751 ◽

2003 ◽

Author(s):

Giovanni Neri

Keyword(s):

Nuclear Receptor ◽

Chromatin Remodeling ◽

Williams Syndrome ◽

Chromatin Remodeling Complex

Faculty Opinions recommendation of Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1019587.222445 ◽

2004 ◽

Author(s):

Venkatesh Murthy

Keyword(s):

Glutamate Transporter ◽

Retrograde Signaling ◽

Inhibitory Synapses ◽

Vesicular Glutamate Transporter ◽

Layer 2

Faculty Opinions recommendation of Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023553.274680 ◽

2005 ◽

Author(s):

Anna-Elina Lehesjoki

Keyword(s):

Transcriptional Regulation ◽

Mental Retardation ◽

Chromatin Remodeling

Faculty Opinions recommendation of Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1026758.325374 ◽

2005 ◽

Author(s):

Michael Kjaer

Keyword(s):

Skeletal Muscle ◽

Extracellular Matrix ◽

Human Skeletal Muscle ◽

Mitochondrial Genes ◽

Lipid Infusion