DNA sequence analysis of spontaneous mutation in a PolA1 strain of Escherichia coli indicates sequence-specific effects

1987 ◽  
Vol 207 (2-3) ◽  
pp. 267-272 ◽  
Author(s):  
Douglas F. Fix ◽  
Philip A. Burns ◽  
Barry W. Glickman
2012 ◽  
Vol 302 (1) ◽  
pp. 4-9 ◽  
Author(s):  
Péter Z. Fekete ◽  
Elzbieta Brzuszkiewicz ◽  
Gabriele Blum-Oehler ◽  
Ferenc Olasz ◽  
Mónika Szabó ◽  
...  

Genetics ◽  
1998 ◽  
Vol 148 (4) ◽  
pp. 1491-1505 ◽  
Author(s):  
Bernard A Kunz ◽  
Karthikeyan Ramachandran ◽  
Edward J Vonarx

AbstractTo help elucidate the mechanisms involved in spontaneous mutagenesis, DNA sequencing has been applied to characterize the types of mutation whose rates are increased or decreased in mutator or antimutator strains, respectively. Increased spontaneous mutation rates point to malfunctions in genes that normally act to reduce spontaneous mutation, whereas decreased rates are associated with defects in genes whose products are necessary for spontaneous mutagenesis. In this article, we survey and discuss the mutational specificities conferred by mutator and antimutator genes in the budding yeast Saccharomyces cerevisiae. The implications of selected aspects of the data are considered with respect to the mechanisms of spontaneous mutagenesis.


Author(s):  
J. Tucker ◽  
K. Shazand ◽  
R. Chiang ◽  
K. Stansmore ◽  
H.U. Sperling-Petersen ◽  
...  

1985 ◽  
Vol 186 (2) ◽  
pp. 283-293 ◽  
Author(s):  
Catherine M. Joyce ◽  
David M. Fujii ◽  
Helaina S. Laks ◽  
Cynthia M. Hughes ◽  
Nigel D.F. Grindley

2000 ◽  
Vol 182 (4) ◽  
pp. 1176-1180 ◽  
Author(s):  
Susan Kinder Haake ◽  
Sean C. Yoder ◽  
Gwynne Attarian ◽  
Kara Podkaminer

ABSTRACT Three native plasmids of Fusobacterium nucleatum were characterized, including DNA sequence analysis of one plasmid, pFN1. A shuttle plasmid, pHS17, capable of transforming Escherichia coli and F. nucleatum ATCC 10953 was constructed with pFN1. pHS17 was stably maintained in the F. nucleatum transformants, and differences in the transformation efficiencies suggested the presence of a restriction-modification system in F. nucleatum.


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