Strain distribution pattern of 25 simple sequence length polymorohisms in the AXB and BXA recombinant inbred strains

1992 ◽  
Vol 3 (12) ◽  
pp. 705-708 ◽  
Author(s):  
Jian-Long Mu ◽  
Yin-Chai Cheah ◽  
Beverly Paigen
1993 ◽  
Vol 4 (3) ◽  
pp. 148-152 ◽  
Author(s):  
Jian-Long Mu ◽  
J�rgen K. Naggert ◽  
Patsy M. Nishina ◽  
Yin-Chai Cheah ◽  
Beverly Paigen

1990 ◽  
Vol 171 (5) ◽  
pp. 1469-1483 ◽  
Author(s):  
A A Scalzo ◽  
N A Fitzgerald ◽  
A Simmons ◽  
A B La Vista ◽  
G R Shellam

The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic CMV infection.


2003 ◽  
Vol 52 (5) ◽  
pp. 415-417 ◽  
Author(s):  
Tamio OHNO ◽  
Jun-ichi KATOH ◽  
Yoshiaki KIKKAWA ◽  
Hiromichi YONEKAWA ◽  
Masahiko NISHIMURA

1996 ◽  
Vol 7 (7) ◽  
pp. 526-532 ◽  
Author(s):  
K. L. Shultz ◽  
K. L. Svenson ◽  
Y. -C. Cheah ◽  
B. Paigen ◽  
W. G. Beamer

1995 ◽  
Vol 6 (12) ◽  
pp. 867-872 ◽  
Author(s):  
K. L. Svenson ◽  
Y. C. Cheah ◽  
K. L. Shultz ◽  
J. L. Mu ◽  
B. Paigen ◽  
...  

1975 ◽  
Vol 36 (3) ◽  
pp. 703-712 ◽  
Author(s):  
Alberto Oliverio ◽  
Merrill F. Elias ◽  
Basil E. Eleftheriou ◽  
C. Castellano

Recombinant inbred strains, their progenitor strains, and their reciprocal F1 hybrids were tested for maze learning in the Lashley III maze and in the Y-water maze. The resulting pattern of strain distribution suggested that the genetic model provided by the RI strains is based on at least two, and possibly many more, loci. There was no evidence of maternal effects or heterosis. Although the BALB/cBy strain represented an extremely high scoring strain for the Lashley maze and a low scoring strain for the Y-maze, presence of albino recombinant inbred strains intermediate to extreme strains and nonsignificantly different from pigmented recombinant inbred strains suggested that the albino gene was not responsible for the observed performance differences.


1972 ◽  
Vol 55 (2) ◽  
pp. 415-420 ◽  
Author(s):  
B. E. ELEFTHERIOU ◽  
D. W. BAILEY

SUMMARY Plasma corticosterone levels were determined fluorometrically in mice of two unrelated highly inbred strains, C57BL/6By and BALB/cBy, and in seven of their derived recombinant-inbred strains as well as their F1 hybrid and backcross generations necessary to arrive at a genetic model for plasma corticosterone levels. It was concluded that the simplest genetic model, and one which fits the experimental results, was one which assumed that plasma corticosterone levels are controlled genetically by two loci with the epistatic interaction indicating dependency of pathways of action for the two genes.


2018 ◽  
Vol 9 ◽  
Author(s):  
Megan K. Mulligan ◽  
Wenyuan Zhao ◽  
Morgan Dickerson ◽  
Danny Arends ◽  
Pjotr Prins ◽  
...  

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