Electrical and mechanical activity of mammalian heart muscle fibres treated with papaverine

1977 ◽  
Vol 299 (3) ◽  
pp. 253-258 ◽  
Author(s):  
Hermann Nawrath ◽  
Thomas Meinertz
Keyword(s):  
Heart Muscle ◽  
Mechanical Activity ◽  
Muscle Fibres ◽  
Mammalian Heart ◽  
Mammalian Heart Muscle

The Croonian Lecture, 1977 - Stretch activation of muscle: function and mechanism

1978 ◽  
Vol 201 (1143) ◽  
pp. 107-130 ◽  
Keyword(s):  
Skeletal Muscle ◽  
Heart Muscle ◽  
Flight Muscle ◽  
Mechanical Activity ◽  
Myosin Filament ◽  
Active Tension ◽  
Stretch Activation ◽  
Mammalian Heart ◽  
Mammalian Heart Muscle ◽  
Vertebrate Skeletal Muscle

Current theories about the mechanism of muscular contraction suppose that the level of enzymic and contractile activity is controlled by the intracellular concentration of calcium ions, the degree of overlap between the myosin and actin filaments and the rate of relative sliding of the filaments. It is now known that in most or all muscles there is a further direct influence of mechanical conditions, usually called stretch activation; changes of length lead to a delayed change of active tension. The effect is large and functionally significant in insect fibrillar flight muscle and in mammalian heart muscle; it is present, but small, in vertebrate skeletal muscle, which probably accounts for its late discovery. In insect fibrillar flight muscle, the delayed tension is responsible for the rhythmic mechanical activity during flight. In mammalian heart muscle it may play a rôle in Starling’s Law. In insect fibrillar muscle, extension produces a maintained increase in actomyosin ATPase and active tension; in vertebrate skeletal muscle, stretch activation is a transient phenomenon. Mammalian heart muscle shows greater maintenance of stretch activation than skeletal muscle; the duration of higher ATPase activity has not yet been determined. The effective mechanical parameter is not overall strain but is probably the strain on an internal structure related to overall stress. Various lines of evidence point to the myosin filament as the location of the sensor. A considerable degree of molecular synchronization occurs during natural insect flight.

scholarly journals THE METABOLISM OF n-BUTYRATE-C14 BY MAMMALIAN HEART MUSCLE

1955 ◽  
Vol 215 (2) ◽  
pp. 823-832
Author(s):  
Victor Lorber ◽  
Margaret Cook
Keyword(s):  
Heart Muscle ◽  
Mammalian Heart ◽  
Mammalian Heart Muscle

Collagen struts of mammalian heart muscle: Structure and function

1984 ◽  
Vol 16 ◽  
pp. 30-30
Author(s):  
T ROBINSON ◽  
S FACTOR ◽  
E SCHWARTZ ◽  
J CAPASSO ◽  
L COHENGOULD ◽  
...  
Keyword(s):  
Heart Muscle ◽  
Structure And Function ◽  
Muscle Structure ◽  
Mammalian Heart ◽  
Mammalian Heart Muscle ◽  
And Function

Magnesium-dependent calcium efflux in mammalian heart muscle

Cell Calcium ◽  
1994 ◽  
Vol 15 (2) ◽  
pp. 175-182 ◽  
Author(s):  
W. Vierling ◽  
A. Stampfl
Keyword(s):  
Heart Muscle ◽  
Calcium Efflux ◽  
Mammalian Heart ◽  
Mammalian Heart Muscle
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