An attempt to quantitate the contribution of antidiuretic hormone to the diuresis of left atrial distension in conscious dogs

1983 ◽  
Vol 396 (2) ◽  
pp. 101-105 ◽  
Author(s):  
G. Kaczmarczyk ◽  
W. Christe ◽  
R. Mohnhaupt ◽  
H. W. Reinhardt
Keyword(s):  
Antidiuretic Hormone ◽  
Left Atrial ◽  
Conscious Dogs ◽  
Left Atrial Distension

Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension

1993 ◽  
Vol 264 (2) ◽  
pp. R369-R375 ◽  
Author(s):  
K. Miki ◽  
Y. Hayashida ◽  
K. Shiraki
Keyword(s):  
Left Atrial ◽  
Steel Wire ◽  
Experimental Period ◽  
Conscious Dogs ◽  
Balloon Inflation ◽  
Renal Sympathetic Nerve Activity ◽  
Sustained Reduction ◽  
The Face ◽  
Left Atrial Distension

The role of cardiac-renal-neural reflex in the natriuresis induced by left atrial balloon inflation was investigated in conscious dogs. Female mongrel dogs were assigned randomly to 1) sham-operated (n = 8), 2) cardiac-denervated (n = 6), and 3) renal-denervated (n = 8) groups. The dogs were chronically instrumented with a bipolar stainless steel wire electrode for measurement of renal sympathetic nerve activity (RSNA). Balloon inflation induced a step increase in left atrial pressure (Pla) by 7.7 +/- 1.7 mmHg, a step decrease in RSNA (-66.6 +/- 5.5%), and concomitant increases in urine flow (441 +/- 142%), osmolal excretion (60 +/- 12%), and sodium excretion (300 +/- 69%) in sham-operated dogs. Renal denervation abolished the diuresis and natriuresis during balloon inflation. Chronic cardiac denervation abolished also the diuresis and natriuresis in the face of a similar increase in Pla. RSNA did not change significantly throughout the experimental period in cardiac-denervated dogs. It is concluded that a sustained reduction of RSNA originating from left atrial mechanoreceptors plays a major role in the natriuresis during left atrial distension in conscious dogs.

Left atrial distension and intrarenal blood flow distribution in conscious dogs

1981 ◽  
Vol 390 (1) ◽  
pp. 44-48 ◽  
Author(s):  
G. Kaczmarczyk ◽  
V. Unger ◽  
R. Mohnhaupt ◽  
H. W. Reinhardt
Keyword(s):  
Blood Flow ◽  
Left Atrial ◽  
Flow Distribution ◽  
Conscious Dogs ◽  
Blood Flow Distribution ◽  
Intrarenal Blood Flow ◽  
Left Atrial Distension

Control of atrial natriuretic factor by right and left atrial distension in pregnant sheep

1995 ◽  
Vol 268 (6) ◽  
pp. R1411-R1417
Author(s):  
D. Javeshghani ◽  
S. Mukaddam-Daher ◽  
L. Fan ◽  
Z. Guan ◽  
J. Gutkowska ◽  
...  
Keyword(s):  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Natriuretic Factor ◽  
Pregnant Sheep ◽  
Vascular Catheters ◽  
The Right ◽  
Left Atrial Distension ◽  
Atrial Natriuretic

Previous studies of the atrial stretch-atrial natriuretic factor (ANF) relationship during pregnancy have employed volume expansion and measured only right atrial pressure (RAP). Consequently, we studied nonpregnant (n = 7) and 115- to 125-day pregnant (n = 7) sheep and assessed the ANF response to changes of RAP and left atrial pressure (LAP) induced by graded balloon inflation. Ewes prepared with vascular catheters and atrial balloons were studied after recovery from preparatory surgical procedures. The basal levels of mean arterial pressure (MAP, 83 +/- 3 mmHg), RAP (2.1 +/- 0.7 mmHg), LAP (4.7 +/- 0.9 mmHg), and heart rate (HR, 102 +/- 6 beats/min) were similar in nonpregnant and pregnant sheep. Pregnancy also resulted in elevation of ANF concentration from 25 +/- 6 to 57 +/- 4 fmol/ml. With right atrial distension, the RAP-ANF relationships were similar in both nonpregnant and pregnant sheep, with a 10-mmHg increase in RAP increasing ANF by an average of 95 +/- 9 fmol/ml. In nonpregnant sheep, the LAP-ANF relationship was more responsive than RAP-ANF because a 10-mmHg increase in LAP resulted in a 193 +/- 10 fmol/ml increase in ANF. Moreover, during pregnancy, the LAP-ANF relationship was significantly more sensitive because a 10-mmHg increase in LAP resulted in a 433 +/- 15 fmol/ml elevation of ANF. These data demonstrate that plasma ANF levels are more responsive to distension of the left atria than to the right. More importantly, the ANF response to left, but not right, atrial distension is enhanced by pregnancy.

scholarly journals The role of left atrial receptors in the diuretic response to left atrial distension

1968 ◽  
Vol 198 (2) ◽  
pp. 487-503 ◽  
Author(s):  
J. R. Ledsome ◽  
R. J. Linden
Keyword(s):  
Left Atrial ◽  
Diuretic Response ◽  
Atrial Receptors ◽  
Left Atrial Distension

Effects of atriopeptin infusion versus effects of left atrial stretch in awake dogs

1986 ◽  
Vol 250 (2) ◽  
pp. R221-R226 ◽  
Author(s):  
K. L. Goetz ◽  
B. C. Wang ◽  
P. G. Geer ◽  
W. D. Sundet ◽  
P. Needleman
Keyword(s):  
Renal Function ◽  
Left Atrial ◽  
Free Water ◽  
Urine Flow ◽  
The Other ◽  
Potassium Excretion ◽  
Water Reabsorption ◽  
Hemodynamic Responses ◽  
Systemic Hemodynamic ◽  
Left Atrial Distension

We infused synthetic atriopeptin III intravenously into 10 conscious dogs while monitoring renal function and systemic hemodynamics. The results obtained from these infusion experiments were compared with results from other experiments in which left atrial distension was performed in the same dogs. Both atriopeptin infusion and left atrial distension caused significant increases in urine flow, sodium excretion, potassium excretion, and free water reabsorption and a significant decrease in renal blood flow. On the other hand, the pattern of systemic hemodynamic responses to atriopeptin infusion were quite different from the hemodynamic responses elicited by left atrial distension. However, there was a striking concordance between the renal effects of atriopeptin and those of left atrial distension. We therefore hypothesize that the renal response to left atrial distension in the conscious dog is mediated largely by the release of natriuretic peptides from the atria.

Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs

1995 ◽  
Vol 268 (2) ◽  
pp. H781-H787 ◽  
Author(s):  
N. Hasebe ◽  
L. Hittinger ◽  
S. Kohin ◽  
Y. T. Shen ◽  
R. M. Graham ◽  
...  
Keyword(s):  
Coronary Sinus ◽  
Left Atrial ◽  
Volume Expansion ◽  
Diastolic Pressure ◽  
Systemic Circulation ◽  
Left Ventricular ◽  
Conscious Dogs ◽  
Volume Loading ◽  
Volume Depletion ◽  
Ventricular Compliance

Alterations in left atrial (LA) and left ventricular (LV) compliance and arterial and coronary sinus atrial natriuretic factor (ANF) concentrations at baseline and in response to both volume depletion and expansion were investigated in 15 conscious dogs with aortic banding-induced LV hypertrophy (LVH) (LV/body wt increased by 64%), which also induced LAH (LA/body wt increased by 61%). With volume expansion coronary sinus ANF increased more (P < 0.05) in dogs with LVH (+427 +/- 88 pg/ml) compared with control dogs (+146 +/- 45 pg/ml). Arterial ANF levels also rose more with volume expansion in LVH. In dogs with LVH, the LV end-diastolic pressure-diameter relationship was shifted to the left with a steeper slope with volume expansion, such that at any given diastolic dimension, diastolic pressure was higher. In contrast, the pressure-dimension relationship for the LA appendage was shifted in the opposite direction during both atrial systolic and diastolic phases, with a more shallow slope in hypertrophy compared with control dogs, resulting in an augmented pressure-dimension product during volume loading in LAH. In conclusion, in dogs with LVH and LAH, enhanced ANF was revealed in the coronary sinus and systemic circulation during volume expansion, which could be due, in part, to a more compliant, but hypertrophied, LA, which responded to equivalent volume loading with an augmented pressure-dimension product.

Ventricular receptors stimulate vasopressin release during hemorrhage

1988 ◽  
Vol 254 (2) ◽  
pp. R204-R211 ◽  
Author(s):  
B. C. Wang ◽  
G. Flora-Ginter ◽  
R. J. Leadley ◽  
K. L. Goetz
Keyword(s):  
Left Atrial ◽  
Heart Rate Response ◽  
Venous Pressure ◽  
Control Level ◽  
Conscious Dogs ◽  
Central Venous ◽  
Vasopressin Release ◽  
Cardiac Denervation ◽  
Plasma Vasopressin ◽  
Vasopressin Secretion

These experiments were designed to investigate whether a reflex arising from ventricular receptors is capable of stimulating vasopressin secretion during hemorrhage. Three groups of conscious dogs (sham operated, cardiac denervated, and ventricular denervated) were hemorrhaged slowly until 30 ml blood/kg body wt had been removed. Hemorrhage produced comparable decreases in stroke volume, central venous pressure, and left atrial pressure in each group of dogs but produced a different pattern of heart rate response in each group. Plasma vasopressin concentrations before hemorrhage did not differ in the three groups of dogs. In sham-operated dogs plasma vasopressin increased from a control level of 2.4 +/- 0.3 to 6.2 +/- 1.7, 200.0 +/- 65.4, and 991.3 +/- 220.9 pg/ml after 10, 20, and 30 ml/kg of blood had been removed, respectively. In contrast, plasma vasopressin did not increase in either cardiac-denervated or ventricular-denervated dogs after 10 ml/kg of blood had been removed, and the increases in circulating vasopressin after 20 and 30 ml/kg hemorrhage were markedly attenuated by cardiac denervation and by ventricular denervation. The magnitude of the increase in plasma vasopressin in the cardiac-denervated and ventricular-denervated dogs did not differ significantly at comparable levels of hemorrhage. The results are consistent with the possibility that a reflex initiated by ventricular receptors is primarily responsible for stimulating the secretion of vasopressin during hemorrhage in conscious dogs.

scholarly journals The effects of vasopressin on the diuretic response to left atrial distension

1972 ◽  
Vol 221 (2) ◽  
pp. 427-440 ◽  
Author(s):  
J. R. Ledsome ◽  
J. M. Mason
Keyword(s):  
Left Atrial ◽  
Diuretic Response ◽  
Left Atrial Distension

Effect of the ouabain-quinidine interaction on left ventricular and left atrial function in conscious dogs.

Circulation ◽  
1983 ◽  
Vol 67 (5) ◽  
pp. 1054-1058 ◽  
Author(s):  
S Goldman ◽  
W D Hager ◽  
M Olajos ◽  
D Perrier ◽  
M Mayersohn
Keyword(s):  
Left Atrial ◽  
Left Ventricular ◽  
Atrial Function ◽  
Left Atrial Function ◽  
Conscious Dogs
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