The effect of ara-C-induced inhibition of DNA synthesis on its cellular pharmacology

1990 ◽  
Vol 25 (6) ◽  
pp. 418-424 ◽  
Author(s):  
Li-Ming Wang ◽  
J. Courtland White ◽  
Robert L. Capizzi
Keyword(s):  
Dna Synthesis ◽  
Cellular Pharmacology ◽  
Inhibition Of Dna Synthesis

scholarly journals Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.

1992 ◽  
Vol 267 (2) ◽  
pp. 691-694 ◽  
Author(s):  
V J LaMorte ◽  
P K Goldsmith ◽  
A M Spiegel ◽  
J L Meinkoth ◽  
J R Feramisco
Keyword(s):  
Dna Synthesis ◽  
Living Cells ◽  
Inhibition Of Dna Synthesis

Inhibition of DNA synthesis and cell division by a cell surface sialoglycopeptide

1989 ◽  
Vol 139 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Heideh Fattaey ◽  
Terry C. Johnson ◽  
Hsin-Hwei Chou
Keyword(s):  
Cell Division ◽  
Cell Surface ◽  
Dna Synthesis ◽  
A Cell ◽  
Inhibition Of Dna Synthesis

Transient inhibition of DNA synthesis by methotrexate, in the rat embryo and foetus

Development ◽  
1971 ◽  
Vol 26 (3) ◽  
pp. 469-474
Author(s):  
C. L. Berry
Keyword(s):  
Folic Acid ◽  
Dna Synthesis ◽  
Folinic Acid ◽  
Rat Embryo ◽  
Acid Inhibitor ◽  
Cellular Events ◽  
Foetal Life ◽  
Specific Antagonist ◽  
Catch Up ◽  
Inhibition Of Dna Synthesis

Massive doses of methotrexate, a folic acid inhibitor, followed by folinic acid, the specific antagonist, have been used to produce a period in which the embryo and foetus are exposed to tetrahydrofolate deficiency with subsequent inhibition of DNA synthesis. The effects of this inhibition vary at different stages of gestation, and in late foetal life provide a useful method of inducing a delay in the appearance of vertebral body ossification centres. This defect is rapidly repaired, although there may be permanent sequelae. It is hoped that this technique will be useful in the study of cellular events in ‘catch-up’ growth.

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