Inhibition of DNA synthesis in ascites hepatoma cells by normal liver extract

1966 ◽  
Vol 123 (2) ◽  
pp. 274-285 ◽  
Author(s):  
Haruki Otsuka ◽  
Hiroshi Terayama
Keyword(s):  
Dna Synthesis ◽  
Liver Extract ◽  
Normal Liver ◽  
Hepatoma Cells ◽  
Ascites Hepatoma ◽  
Inhibition Of Dna Synthesis

scholarly journals THE REPLICATION TIME AND PATTERN OF CARCINOGEN-INDUCED HEPATOMA CELLS

1964 ◽  
Vol 22 (2) ◽  
pp. 341-350 ◽  
Author(s):  
Joseph Post ◽  
Joseph Hoffman
Keyword(s):  
Tumor Cell ◽  
Dna Synthesis ◽  
Tumor Cells ◽  
Cell Population ◽  
Tritiated Thymidine ◽  
Normal Liver ◽  
Hepatoma Cells ◽  
Male Rats ◽  
Time Intervals ◽  
Replication Time

The replication time and pattern have been investigated in hepatoma cells induced by feeding 3'Me-DAB to male rats for 5 months. With the use of tritiated thymidine as a DNA label along with autoradiography, mitotic nuclear labeling has been studied 0.5 to 72 hours after the administration of the label. The following time intervals have been estimated: replication time, 31 hours; DNA synthesis, 17 hours; G2 plus Mitosis, 2 hours; G1, 12 hours. Only about 8 per cent of the tumor cell (interphase) population is "flash" labeled, following a single dose of 50 µC of H3TDR. This group of cells has been followed through three cycles of division. The repeated rhythmic passage of tumor cells through cell division is similar to that previously reported for normal liver cells in the growing rat. However, tumor cells have longer replication and DNA synthesis times. In addition, the several time intervals studied vary more in the tumor cell population than they do in the growing normal cell population.

scholarly journals Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.

1992 ◽  
Vol 267 (2) ◽  
pp. 691-694 ◽  
Author(s):  
V J LaMorte ◽  
P K Goldsmith ◽  
A M Spiegel ◽  
J L Meinkoth ◽  
J R Feramisco
Keyword(s):  
Dna Synthesis ◽  
Living Cells ◽  
Inhibition Of Dna Synthesis

The effect of ara-C-induced inhibition of DNA synthesis on its cellular pharmacology

1990 ◽  
Vol 25 (6) ◽  
pp. 418-424 ◽  
Author(s):  
Li-Ming Wang ◽  
J. Courtland White ◽  
Robert L. Capizzi
Keyword(s):  
Dna Synthesis ◽  
Cellular Pharmacology ◽  
Inhibition Of Dna Synthesis

scholarly journals Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Satoshi Tsuno ◽  
Xinhui Wang ◽  
Kohei Shomori ◽  
Junichi Hasegawa ◽  
Norimasa Miura
Keyword(s):  
Normal Liver ◽  
Hepatoma Cells ◽  
Liver Tissues
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