Binding of3H-diazepam with brain synaptic membranes during the development of generalized epileptic activity

1985 ◽  
Vol 100 (6) ◽  
pp. 1664-1666
Author(s):  
M. M. Bordyukov ◽  
G. N. Kryzhanovskii ◽  
E. V. Nikushkin ◽  
E. D. Bogdanova ◽  
L. L. Prilipko
Keyword(s):  
Epileptic Activity ◽  
Synaptic Membranes ◽  
Generalized Epileptic Activity

State of the antioxidant system during induction of primary generalized epileptic activity in rats

1985 ◽  
Vol 100 (5) ◽  
pp. 1489-1492 ◽  
Author(s):  
I. R. Tupeev ◽  
M. M. Bordyukov ◽  
G. N. Kryzhanovskii ◽  
E. V. Nikushkin
Keyword(s):  
Antioxidant System ◽  
Epileptic Activity ◽  
Generalized Epileptic Activity

Effect of brain extracts from rats subjected to metrazol kindling on generalized epileptic activity

1989 ◽  
Vol 107 (3) ◽  
pp. 291-294
Author(s):  
G. N. Kryzhanovskii ◽  
M. Yu. Karganov ◽  
A. A. Shandra ◽  
L. S. Godlevskii ◽  
V. K. Lutsenko ◽  
...  
Keyword(s):  
Epileptic Activity ◽  
Brain Extracts ◽  
Generalized Epileptic Activity ◽  
Metrazol Kindling

Effect of the calcium channel blocker ryodipine on focal and generalized epileptic activity

1989 ◽  
Vol 108 (5) ◽  
pp. 1562-1566
Author(s):  
M. N. Karpova ◽  
O. Yu. Pankov ◽  
R. N. Glebov ◽  
S. K. Germane ◽  
V. E. Klusha ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Epileptic Activity ◽  
Generalized Epileptic Activity

Effect of metrazol-induced epileptic activity on transport Ca-ATP-ase activity in rat brain synaptic membranes

1987 ◽  
Vol 104 (1) ◽  
pp. 895-898
Author(s):  
G. N. Kryzhanovskii ◽  
I. L. Tverdislova ◽  
M. N. Karpova ◽  
O. L. Agatova ◽  
R. N. Glebov
Keyword(s):  
Rat Brain ◽  
Epileptic Activity ◽  
Synaptic Membranes

scholarly journals Effect of the compound GIZH -290 and levetiracetam on epileptic activity in rat brain structures on EEG models of bemegrid-induced seizures

2021 ◽  
pp. 14-18
Author(s):  
T. A. Voronina ◽  
S. A. Litvinova ◽  
I. G. Kovalev
Keyword(s):  
Rat Brain ◽  
Lateral Hypothalamus ◽  
Sensorimotor Cortex ◽  
Dorsal Hippocampus ◽  
Brain Structures ◽  
High Amplitude ◽  
Epileptic Activity ◽  
Paroxysmal Activity ◽  
Epileptic Discharges ◽  
Generalized Epileptic Activity

The effect of levetiracetam (a derivative of 4-phenylpyrrolidone) and its original analog, the compound GIZH-290, on primary generalized epileptic activity (EpA) in rat brain structures (sensorimotor cortex, dorsal hippocampus-CA3 field and lateral hypothalamus field) on EEG models of bemegridinduced seizures was studied. It was found that EpA, after the introduction of bemegrid, appears in 1–2 minutes in the form of prolonged generalized high-amplitude discharges and is registered within 3 hours. GIZH-290 (5 mg/kg, intraperitoneal, 15 minutes after bemegrid) causes a significant (p < 0.05) decrease in the number of epileptic discharges in the cortex and at the level of the trend in the hippocampus, which is accompanied by a decrease in the amplitude of the Epi-discharges. Levetiracetam at a dose of 200 mg / kg does not significantly change the severity of paroxysmal activity (the number of convulsive discharges and their duration) caused by bemegrid.

scholarly journals Multiple Dural Tuberculomas Presenting as Leptomeningeal Carcinomatosis

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Hasan Kocaeli ◽  
Özgür Taşkapılıoğlu ◽  
Elif Başaran ◽  
Ahmet Karaoğlu ◽  
Ahmet Bekar
Keyword(s):  
Clinical Presentation ◽  
Systemic Disease ◽  
Giant Cells ◽  
Leptomeningeal Carcinomatosis ◽  
Immunocompetent Patient ◽  
Epileptic Activity ◽  
Resonance Imaging ◽  
History Of ◽  
Magnetic Resonance Imaging Mri ◽  
Generalized Epileptic Activity

Objective and Importance. We present the rare occurrence of multiple dural-based tuberculomas mimicking leptomeningeal carcinomatosis in a young immunocompetent patient.Clinical Presentation. A 36-year-old man presented with a 2-month history of generalized epileptic activity and altered perception. Neurological examination was remarkable for bilateral Babinski's sign. Cranial magnetic resonance imaging (MRI) revealed multiple dural-based enhancing lesions with cerebral edema.Intervention. A right frontal craniotomy was performed for diagnosis. Histological examination revealed multiple confluent necrotizing and nonnecrotizing granulomas with giant cells which was consistent with tuberculosis (TB), and the patient was placed on anti-TB therapy for 24 months.Conclusion. To the best of our knowledge isolated diffuse involvement of the dura mater by TB, mimicking leptomeningeal carcinomatosis, as the sole manifestation of disease has not been reported before. Since pachymeningeal TB is rarely suspected when atypical radiological appearance is combined with the absence of systemic disease, biopsy is inevitably required for diagnosis.

CONTEXTUAL LEARNING IN THE MORRIS WATER MAZE

2018 ◽  
pp. 13-20
Author(s):  
Е.И. Захарова ◽  
З.И. Сторожева ◽  
А.Т. Прошин ◽  
М.Ю. Монаков ◽  
А.М. Дудченко
Keyword(s):  
Morris Water Maze ◽  
Choline Acetyltransferase ◽  
Water Maze ◽  
Synaptic Membranes ◽  
Projection Neurons ◽  
Synaptic Organization ◽  
Acetyltransferase Activity ◽  
Cholinergic Interneurons ◽  
Late Stages ◽  
Choline Acetyltransferase Activity

Цель - исследование холинергической синаптической организации функций обучения и памяти у крыс с разными когнитивными способностями. Методы. Крыс обучали на пространственной обстановочной модели в водном лабиринте Морриса. Через 2-3 сут. после окончания тренировок животных декапитировали, из неокортекса и гиппокампа с помощью центрифугирования выделяли субфракции синаптических мембран и синаптоплазмы легких и тяжелых синаптосом. В синаптических субфракциях определяли активность ключевого фермента холинергических нейронов холинацетилтрансферазы (ХАТ). Сравнивали результаты тестирования (время достижения скрытой платформы) и активность фермента у способных и неспособных к обучению крыс. Результаты. Были выявлены: 1) различия в холинергической организации исследованных функций в процессе обучения у способных и неспособных к обучению крыс, в том числе: положительные корреляции активности ХАТ в синапсах проекционных нейронов неокортекса у способных крыс со временем достижения платформы на промежуточных этапах обучения и в синапсах проекционных нейронов гиппокампа у неспособных крыс на позднем этапе обучения; разнонаправленные корреляции активности ХАТ в синапсах, предположительно, интернейронов гиппокампа (фракция тяжелых синаптосом) у способных и неспособных крыс на начальном и позднем этапах обучения; 2) индивидуальность холинергической организации функций на всех этапах обучения. Выводы. Полученные данные свидетельствуют в пользу представлений о специфике холинергической организации функций пространственного обстановочного обучения у крыс с выраженными и слабыми способностями к обучению, а также избирательной роли холинергических интернейронов гиппокампа на исходном этапе обучения и в консолидации памяти. In order to expand the knowledge about neuronal organization of the cognitive functions required for understanding plastic processes in the brain, we investigated the cholinergic synaptic organization of learning and memory functions in rats with different cognitive abilities. Methods. Rats were trained on a contextual situation model in the Morris water maze. At 2-3 days after the end of training, animals were decapitated, and subfractions of synaptic membranes and synaptoplasm of light and heavy synaptosomes were isolated from the cortex and the hippocampus by centrifugation. In synaptic subfractions, activity of the key enzyme of cholinergic neurons, choline acetyltransferase, was measured. We compared the test results (latent period to reach the hidden platform) and the enzyme activity in capable (lower quartile) and incapable of learning rats (upper quartile). Results. The following was found: 1) differences in the cholinergic organization of studied functions in capable and uncapable of learning rats during training, including: positive correlations of choline acetyltransferase activity in synapses of projection neurons in the cortex of capable rats with latency to reach the platform at intermediate stages of training and in the hippocampus ofincapable rats at late stages of training; multidirectional correlations of choline acetyltransferase activity in synapses of hippocampal, presumably, interneurons (heavy synaptosomes) in capable and incapable rats at early and late stages of training; 2) distinctness of the cholinergic organization of functions at all stages of training. Conclusions. The study demonstrated for the first time a specificity of the cholinergic organization of functions in spatial situational learning of rats with strong and poor learning abilities and a selective role of hippocampal cholinergic interneurons at the initial stage of learning and in memory consolidation.

Epileptogenicity and Epileptic Activity: Mechanisms in an Invertebrate Model Nervous System

2004 ◽  
Vol 5 (5) ◽  
pp. 473-484 ◽  
Author(s):  
U. Altrup
Keyword(s):  
Nervous System ◽  
Epileptic Activity ◽  
Invertebrate Model

Halothane enhances the binding of diazepam to synaptic membranes from rat cerebral cortex

1991 ◽  
Vol 35 (3) ◽  
pp. 205-207 ◽  
Author(s):  
S. Nakao ◽  
T. Arai ◽  
M. Murakawa ◽  
K. Mori
Keyword(s):  
Cerebral Cortex ◽  
Rat Cerebral Cortex ◽  
Synaptic Membranes
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