Tyrosine hydroxylase activity in the brain of rats with different levels of initial alcohol motivation

1981 ◽  
Vol 91 (5) ◽  
pp. 608-610
Author(s):  
V. S. Kudrin ◽  
A. B. Kampov-Polevoi ◽  
A. I. Varkov ◽  
M. F. Mineeva
Keyword(s):  
Tyrosine Hydroxylase ◽  
Alcohol Motivation ◽  
Hydroxylase Activity ◽  
Tyrosine Hydroxylase Activity ◽  
The Brain ◽  
Different Levels

Reduction in brain tyrosine hydroxylase activity following acetylcholinesterase blockade in rats

1976 ◽  
Vol 54 (5) ◽  
pp. 774-778 ◽  
Author(s):  
J. Steven Richardson ◽  
Friedhelm Lamprecht ◽  
Tomislav Kazic ◽  
Irwin J. Kopin
Keyword(s):  
Tyrosine Hydroxylase ◽  
Cholinergic Neurons ◽  
Acetylcholinesterase Inhibitors ◽  
Chronic Administration ◽  
Acute Effect ◽  
Hydroxylase Activity ◽  
Rapid Reduction ◽  
Tyrosine Hydroxylase Activity ◽  
Biphasic Effect ◽  
The Brain

Activation of cholinergic neurons in the brain is produced by administration of the acetylcholinesterase inhibitors physostigmine and diisopropylfluorophosphate (DFP). This activation has a biphasic effect on tyrosine hydroxylase (EC 1.14.3–) activity. The acute effect of DFP, 1 mg/kg, intraperitoneally, or physostigmine, 0.2 mg/kg, intravenously, or 10 μg, intraventricularly, was a rapid reduction in tyrosine hydroxylase activity in the hypothalamus. The activities of DOPA decarboxylase (EC 4.1.1.28) and dopamine-β-hydroxylase (EC 1.14.17.1) were not changed. In contrast to the acute effect, chronic administration of physostigmine, 0.2 mg/kg, intravenously, twice daily for 7 days produced an increase in tyrosine hydroxylase activity in the hypothalamus. The rapid acute effects may be due to an allosteric inactivation of tyrosine hydroxylase, while the chronic effects may reflect enzyme induction.

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