Genetic studies of daily variations of first-step enzymes of monoamines metabolism in the brain of inbred strains of mice and hybrids. II. Daily variations of tyrosine hydroxylase activity in the locus coeruleus

1980 ◽  
Vol 191 (1) ◽  
pp. 205-213 ◽  
Author(s):  
Jean-Paul Natali ◽  
Amanda McRae-Degueurce ◽  
Peter Keane ◽  
Gabriel Debilly ◽  
Jean-François Pujol
Keyword(s):  
Tyrosine Hydroxylase ◽  
Locus Coeruleus ◽  
Inbred Strains ◽  
Hydroxylase Activity ◽  
Genetic Studies ◽  
Daily Variations ◽  
Tyrosine Hydroxylase Activity ◽  
Inbred Strains Of Mice ◽  
The Brain ◽  
Monoamines Metabolism

Increase in tyrosine hydroxylase activity in the locus coeruleus of the rat brain after contralateral lesioning

1975 ◽  
Vol 93 (3) ◽  
pp. 564-569 ◽  
Author(s):  
Michel Buda ◽  
Bernard Roussel ◽  
Bernard Renaud ◽  
Jean-Fran¢ois Pujol
Keyword(s):  
Tyrosine Hydroxylase ◽  
Locus Coeruleus ◽  
Rat Brain ◽  
Hydroxylase Activity ◽  
Tyrosine Hydroxylase Activity

Tyrosine hydroxylase activity in the locus coeruleus of conscious rats: Differences with the anesthetized rats

1994 ◽  
Vol 34 (6) ◽  
pp. 595-599 ◽  
Author(s):  
Frédéric Robert ◽  
Catherine Ortemann ◽  
Michèle Seccia ◽  
Bernard Renaud ◽  
Laura Lambás-señas
Keyword(s):  
Tyrosine Hydroxylase ◽  
Locus Coeruleus ◽  
Hydroxylase Activity ◽  
Conscious Rats ◽  
Tyrosine Hydroxylase Activity ◽  
Anesthetized Rats

Reduction in brain tyrosine hydroxylase activity following acetylcholinesterase blockade in rats

1976 ◽  
Vol 54 (5) ◽  
pp. 774-778 ◽  
Author(s):  
J. Steven Richardson ◽  
Friedhelm Lamprecht ◽  
Tomislav Kazic ◽  
Irwin J. Kopin
Keyword(s):  
Tyrosine Hydroxylase ◽  
Cholinergic Neurons ◽  
Acetylcholinesterase Inhibitors ◽  
Chronic Administration ◽  
Acute Effect ◽  
Hydroxylase Activity ◽  
Rapid Reduction ◽  
Tyrosine Hydroxylase Activity ◽  
Biphasic Effect ◽  
The Brain

Activation of cholinergic neurons in the brain is produced by administration of the acetylcholinesterase inhibitors physostigmine and diisopropylfluorophosphate (DFP). This activation has a biphasic effect on tyrosine hydroxylase (EC 1.14.3–) activity. The acute effect of DFP, 1 mg/kg, intraperitoneally, or physostigmine, 0.2 mg/kg, intravenously, or 10 μg, intraventricularly, was a rapid reduction in tyrosine hydroxylase activity in the hypothalamus. The activities of DOPA decarboxylase (EC 4.1.1.28) and dopamine-β-hydroxylase (EC 1.14.17.1) were not changed. In contrast to the acute effect, chronic administration of physostigmine, 0.2 mg/kg, intravenously, twice daily for 7 days produced an increase in tyrosine hydroxylase activity in the hypothalamus. The rapid acute effects may be due to an allosteric inactivation of tyrosine hydroxylase, while the chronic effects may reflect enzyme induction.

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