Anticonvulsant properties of the cerebrospinal fluid due to antiepileptic system activation

1988 ◽  
Vol 106 (2) ◽  
pp. 1082-1085
Author(s):  
G. N. Kryzhanovskii ◽  
A. A. Shandra ◽  
L. S. Godlevskii
Keyword(s):  
Cerebrospinal Fluid ◽  
Antiepileptic System ◽  
System Activation

Long-term Supplementation with Β Vitamins does not Change Plasma Neopterin Concentrations in Demented Patients

Pteridines ◽  
2006 ◽  
Vol 17 (4) ◽  
pp. 135-144 ◽  
Author(s):  
Katharina Schroecksnadel ◽  
Birgit Gruber ◽  
Barbara Frick ◽  
Marcel Jenny ◽  
Maximilian Ledochowski ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Vitamin Supplementation ◽  
Rapid Decline ◽  
Folate Supplementation ◽  
Immune System Activation ◽  
System Activation ◽  
Immune Activation Marker

Abstract Inflammation and immune system activation seem to play an important role in the development and progression of dementia. Also concentrations of immune activation marker neopterin are increased in serum and cerebrospinal fluid of some patients with dementia, and a significant relationship is found between concentrations of neopterin and homocysteine. Β vitamin supplementation is able to rapidly slow-down homocysteine formation in patients. However, no change of neopterin was found within one month of such therapy. In this study, scrum concentrations of neopterin and homocysteine were investigated in 58 patients with Alzheimer's disease (n=30), vascular dementia (n=12) and mild cognitive impairment (n=16) during 1 -3 months of supplementation with Β vitamins (Beneitran compositum®)with monthly increasing dose ( 1 - 6 tablets a day). No change of neopterin concentrations was observed In the patients groups throughout the whole study period (all ρ >0.05). As was reported earlier, a rapid decline of homocysteine concentrations was achieved already within the first month of supplementation (p <0.01 ), however, no further change of homocysteine was observed later on despite accelerated dose of vitamin supplements. Β vitamin supplementation did not influence neopterin concentrations, and also the longer period of supplementation had no effect. The question remains, if solely the lowering of homocysteine concentrations by folate supplementation could have any beneficial effect to modulate the course of dementia when the immunopathogenetic mechanisms are not influenced.

Antiepileptic Properties of Cerebrospinal Fluid After Activation of the Antiepileptic System of the Brain

Epilepsia ◽  
1989 ◽  
Vol 30 (5) ◽  
pp. 631-635 ◽  
Author(s):  
G. N. Kryzhanovsky ◽  
A. A. Shandra ◽  
L. S. Godlevsky ◽  
M. Y. Karganov
Keyword(s):  
Cerebrospinal Fluid ◽  
Antiepileptic System ◽  
The Brain

Aerodynamic and Acoustic Voice Measures Before and After an Acute Public Speaking Stressor

2020 ◽  
Vol 63 (10) ◽  
pp. 3311-3325
Author(s):  
Brittany L. Perrine ◽  
Ronald C. Scherer
Keyword(s):  
Fundamental Frequency ◽  
Salivary Cortisol ◽  
Public Speaking ◽  
Stress System ◽  
Before And After ◽  
Subglottal Pressure ◽  
Response To Stress ◽  
System Activation ◽  
Speaking Fundamental Frequency ◽  
Pituitary Adrenal Axis

Purpose The goal of this study was to determine if differences in stress system activation lead to changes in speaking fundamental frequency, average oral airflow, and estimated subglottal pressure before and after an acute, psychosocial stressor. Method Eighteen vocally healthy adult females experienced the Trier Social Stress Test (TSST) to activate the hypothalamic–pituitary–adrenal axis. The TSST includes public speaking and performing mental arithmetic in front of an audience. At seven time points, three before the stressor and four after the stressor, the participants produced /pa/ repetitions, read the Rainbow Passage, and provided a saliva sample. Measures included (a) salivary cortisol level, (b) oral airflow, (c) estimated subglottal pressure, and (d) speaking fundamental frequency from the second sentence of the Rainbow Passage. Results Ten of the 18 participants experienced a hypothalamic–pituitary–adrenal axis response to stress as indicated by a 2.5-nmol/L increase in salivary cortisol from before the TSST to after the TSST. Those who experienced a response to stress had a significantly higher speaking fundamental frequency before and immediately after the stressor than later after the stressor. No other variable varied significantly due to the stressor. Conclusions This study suggests that the idiosyncratic and inconsistent voice changes reported in the literature may be explained by differences in stress system activation. In addition, laryngeal aerodynamic measures appear resilient to changes due to acute stress. Further work is needed to examine the influence of other stress systems and if these findings hold for dysphonic individuals.

Traumatic Cerebrospinal Fluid Leakage

1983 ◽  
Vol 16 (3) ◽  
pp. 623-632 ◽  
Author(s):  
James Ryan Chandler
Keyword(s):  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Leakage ◽  
Fluid Leakage
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