Mechanisms of inhibition of creatine kinase and aspartate aminotransferase activity of rat skeletal muscles by neutrophils

1992 ◽  
Vol 114 (6) ◽  
pp. 1800-1803
Author(s):  
T. N. Petrova ◽  
V. I. Morozov
Keyword(s):  
Creatine Kinase ◽  
Aspartate Aminotransferase ◽  
Skeletal Muscles ◽  
Aminotransferase Activity

scholarly journals Effect of conditioning and exercise type on serum creatine kinase and aspartate aminotransferase activity

2010 ◽  
Vol 27 (S18) ◽  
pp. 243-247 ◽  
Author(s):  
P. D. SICILIANO ◽  
L. M. LAWRENCE ◽  
KRISTIN DANIELSEN ◽  
DEBRA M. POWELL ◽  
K. N. THOMPSON
Keyword(s):  
Creatine Kinase ◽  
Aspartate Aminotransferase ◽  
Serum Creatine Kinase ◽  
Aminotransferase Activity ◽  
Exercise Type

Production and certification of secondary enzyme reference materials (ERMs). Part 1: Preparation of the sera and some of their properties.

1986 ◽  
Vol 32 (10) ◽  
pp. 1901-1905 ◽  
Author(s):  
J C Koedam ◽  
G M Steentjes ◽  
S Buitenhuis ◽  
E Schmidt ◽  
R Klauke
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Reference Material ◽  
Human Serum ◽  
Dehydrogenase Activity ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Glutamate Dehydrogenase Activity ◽  
The Stability ◽  
Clinical Enzymology

Abstract We produced three batches of a human-serum-based enzyme reference material (ERM) enriched with human aspartate aminotransferase (EC 2.6.1.1), alanine aminotransferase (EC 2.6.1.2), creatine kinase (EC 2.7.3.2), and lactate dehydrogenase (EC 1.1.1.27). The added enzymes were not exhaustively purified; thus the final ERMs contained some enzymes as contaminants, of which only glutamate dehydrogenase activity might interfere. The stability during storage and after reconstitution was good. The commutability of the four enzymes in the three ERM batches was also good, except when German or Scandinavian methods for aminotransferases were involved. The temperature-conversion factors for the ERMs were equivalent to those for patients' sera. Reactivation after reconstitution was complete within 5 min and was independent of the temperature of the reconstitution fluid. We believe that these secondary ERMs will aid in the transfer of accuracy between well-defined reference methods and daily working methods so that clinical enzymology results will become more comparable from laboratory to laboratory.

scholarly journals Clinical Evaluation of Creatine Kinase and Aspartate Aminotransferase for Monitoring Muscle Effort in Working Dogs in Different Simulated Fieldworks

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1879
Author(s):  
Giuseppe Spinella ◽  
Simona Valentini ◽  
Vincenzo Musella ◽  
Enrico Bortolotti ◽  
Mirella Lopedote
Keyword(s):  
Creatine Kinase ◽  
Aspartate Aminotransferase ◽  
Physiological Parameters ◽  
Inclusion Criteria ◽  
Search Activity ◽  
Fitness Level ◽  
Before And After ◽  
Working Dogs ◽  
Clinical Profiles ◽  
Unknown Area

The clinical profiles of muscle biomarkers (Creatine Kinase–CK-and Aspartate Aminotransferase–AST) performed during training may help in determining the fitness level of dogs and their potentiality to perform specific activities. This study investigated the potential variations of physiological parameters and muscular biomarkers in trained search and rescue dogs during search activity in two different areas. The aim was to verify the absence of any muscular enzymes after 20 min of search activity. The variations of physiological parameters (pulse rate; respiratory rate; rectal body temperature) and skeletal muscular biomarkers (CK and AST) were evaluated before and after search activity. Twenty-three trained dogs met the inclusion criteria and were divided into two groups. One group experienced search activity in a well-known area, while the second one in a similar, but unknown, area. The results for physiological parameters and skeletal muscular biomarkers values showed no significant differences between the two groups (p > 0.05), confirming that an effective conditioning protects against enzymatic alteration during a 20 min duration of submaximal activity.

scholarly journals Local myotoxicity of ketamine hydrochloride in the marmoset

1987 ◽  
Vol 21 (1) ◽  
pp. 60-67 ◽  
Author(s):  
C. W. Davy ◽  
P. N. Trennery ◽  
J. G. Edmunds ◽  
J. F. B. Altman ◽  
D. A. Eichler
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Physical Properties ◽  
Aspartate Aminotransferase ◽  
Solution Ph ◽  
Histopathological Findings ◽  
Plasma Enzyme ◽  
Routine Blood ◽  
Ketamine Hydrochloride ◽  
Injection Procedure

An investigation of raised plasma aspartate aminotransferase (AST) in marmosets after intramuscular ketamine injection suggested a local myotoxicity. This was confirmed by a range of histopathological findings from myofibrillar striation loss to necrosis. In addition to the elevations in AST levels, creatine kinase and the lactate dehydrogenase-5 isoenzyme levels were elevated. It was further demonstrated that, although the physical properties of the injectable solution (pH, osmolality) and to a lesser extent the injection procedure itself caused slight changes in plasma enzyme levels, the ketamine was predominantly responsible for the lesion. No hepatic interactions were seen. This effect should be taken into consideration when this anaesthetic is used in the marmoset if the primary objectives of the experiment entail routine blood analyses.

Aspartate Aminotransferase Activity in Gingival Crevicular Fluid During Orthodontic Treatment. A Controlled Short-Term Longitudinal Study

2003 ◽  
Vol 74 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Giuseppe Perinetti ◽  
Michele Paolantonio ◽  
Michele D'Attilio ◽  
Domenico D'Archivio ◽  
Marco Dolci ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Aspartate Aminotransferase ◽  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Aminotransferase Activity ◽  
Short Term ◽  
Crevicular Fluid
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