Human neutrophil swelling induced by immune complexes and aggregated IgG

Inflammation ◽  
1981 ◽  
Vol 5 (3) ◽  
pp. 213-222 ◽  
Author(s):  
Eric R. Hurd ◽  
Yoshimi Hashimoto
Keyword(s):  
Immune Complexes ◽  
Human Neutrophil

scholarly journals Immune Complexes Isolated from Patients with Pulmonary Tuberculosis Modulate the Activation and Function of Normal Granulocytes

2012 ◽  
Vol 19 (12) ◽  
pp. 1965-1971 ◽  
Author(s):  
P. Senbagavalli ◽  
J. Nancy Hilda ◽  
V. D. Ramanathan ◽  
V. Kumaraswami ◽  
Thomas B. Nutman ◽  
...  
Keyword(s):  
Immune Response ◽  
Pulmonary Tuberculosis ◽  
Intracellular Calcium ◽  
Immune Complexes ◽  
Oxidative Burst ◽  
Human Neutrophil ◽  
Platelet Activating Factor ◽  
The Other ◽  
And Function ◽  
Granulocyte Function

ABSTRACTCirculating immune complexes (ICs) are associated with the pathogenesis of several diseases. Very little is known about the effect of ICs on the host immune response in patients with tuberculosis (TB). The effects of ICs isolated from patients with TB in modulating the release of calcium, cytokines, and granular proteins were studied in normal granulocytes, as were their chemotactic, phagocytic, and oxidative burst processes. ICs from TB patients induced decreased production of cytokines and platelet-activating factor (PAF) from normal granulocytes. ICs from TB patients also induced enhanced chemotaxis and phagocytosis but caused diminished oxidative burst. This was accompanied by an increased release in intracellular calcium. On the other hand, ICs from TB patients induced increased release of the granular proteins human neutrophil peptides 1 to 3 (HNP1–3). Thus, ICs from patients with TB exhibit a profound effect on granulocyte function with activation of certain effector mechanisms and dampening of others.

scholarly journals HUMAN NEUTROPHIL (PMN) INTERACTIONS WITH HUMAN IMMUNE COMPLEXES (IC)

1987 ◽  
Vol 21 (4) ◽  
pp. 297A-297A ◽  
Author(s):  
Harvey J Cohen ◽  
Kazuhiko Takahashi ◽  
John C Whitin ◽  
Margaret E Chovaniec
Keyword(s):  
Immune Complexes ◽  
Human Neutrophil ◽  
Human Immune

scholarly journals Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1

2014 ◽  
Vol 193 (4) ◽  
pp. 1954-1965 ◽  
Author(s):  
Martina Behnen ◽  
Christoph Leschczyk ◽  
Sonja Möller ◽  
Tobit Batel ◽  
Matthias Klinger ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Human Neutrophil ◽  
Neutrophil Extracellular Trap ◽  
Neutrophil Granulocytes ◽  
Extracellular Trap

scholarly journals α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

2010 ◽  
Vol 120 (12) ◽  
pp. 4236-4250 ◽  
Author(s):  
David A. Bergin ◽  
Emer P. Reeves ◽  
Paula Meleady ◽  
Michael Henry ◽  
Oliver J. McElvaney ◽  
...  
Keyword(s):  
Immune Complexes ◽  
Human Neutrophil ◽  
Neutrophil Chemotaxis ◽  
Soluble Immune Complexes

Effect of endothelins on human neutrophil activation by immune complexes

2006 ◽  
Vol 6 (7) ◽  
pp. 1119-1125 ◽  
Author(s):  
E.C. Paulino ◽  
A.A. Steil ◽  
S. Jancar
Keyword(s):  
Immune Complexes ◽  
Human Neutrophil ◽  
Neutrophil Activation

A Sensitive On-Grid Immunoelectron Microscopic Procedure for Diagnosis of Rotavirus Infection

1980 ◽  
Vol 38 ◽  
pp. 506-507
Author(s):  
M. F. Miller ◽  
A. R. Rubenstein
Keyword(s):  
Electron Microscopy ◽  
Specific Antibody ◽  
Immune Complexes ◽  
Acute Gastroenteritis ◽  
Plant Viruses ◽  
Aggregation Process ◽  
Microscopic Technique ◽  
Fecal Material ◽  
Present Communication ◽  
Number Of Particles

Studies of rotavirus particles in humans, monkeys and various non-primates with acute gastroenteritis have involved detection of virus in fecal material by electron microscopy. The EM techniques most commonly employed have been the conventional negative staining (Fig. 1) and immune aggregation (Fig. 2) procedures. Both methods are somewhat insensitive and can most reliably be applied to samples containing large quantities of virus either naturaLly or as a result of concentration by ultracentrifugation. The formation of immune complexes by specific antibody in the immune aggregation procedures confirms the rotavirus diagnosis, but the number of particles per given microscope field is effectively reduced by the aggregation process. In the present communication, we describe use of an on-grid immunoelectron microscopic technique in which rotavirus particles are mounted onto microscope grids that were pre-coated with specific antibody. The technique is a modification of a method originalLy introduced by Derrick (1) for studies of plant viruses.

Localization of Immune Complexes in the Basement Membrane of the Ductuli Efferentes of the Rhesus Monkey

1980 ◽  
Vol 38 ◽  
pp. 456-457
Author(s):  
D. Marsh
Keyword(s):  
Basement Membrane ◽  
Fluorescence Microscopy ◽  
Rhesus Monkey ◽  
Immune Complex ◽  
Immune Complexes ◽  
Vas Deferens ◽  
Frozen Sections ◽  
Efferent Ducts ◽  
Complex Deposition ◽  
Sperm Antibodies

As a result of vasectomy, spermatozoa are confined to the epididymis and vas deferens, where they degenerate, releasing antigens that enter the circulation or are engulfed by macrophages. Multiple antigens of the sperm can elicit production of autoantibodies; circulating anti-sperm antibodies are found in a large percentage of vasectomized men, indicating the immunogenicity of the sperm. The increased prevalence of macrophages in the liomen of the rhesus monkey testicular efferent ducts after vasectomy led to further study of this region. Frozen sections were used for evaluation of immunopathological status by fluorescence microscopy with fluorescein-conjugated antibody. Subsequent granular deposits of immune complexes were revealed by positive immunofluorescence staining for complement. The immune complex deposition in the basement membrane surrounding the efferent ducts implies that this region is involved in antigen leakage (Fig. 1).

Inhibition of human neutrophil function by gastrin

1997 ◽  
Vol 56 (1-3) ◽  
pp. 209
Author(s):  
M De la Fuente
Keyword(s):  
Human Neutrophil ◽  
Neutrophil Function
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