Aldicarb immunomodulation in mice: An inverse dose-response to parts per billion levels in drinking water

1987 ◽  
Vol 16 (4) ◽  
pp. 433-439 ◽  
Author(s):  
Leon John Olson ◽  
Barbara J. Erickson ◽  
Ronald D. Hinsdill ◽  
Jeffrey A. Wyman ◽  
Warren P. Porter ◽  
...  
Keyword(s):  
Drinking Water ◽  
Dose Response

scholarly journals Dose-response meta-analysis of arsenic exposure in drinking water and hypertension

Heliyon ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. e06409
Author(s):  
Afsaneh Amiri ◽  
Yaser Mokhayeri ◽  
Rasool Mohammadi ◽  
Mohammad Amin Karami ◽  
Mansour Ghaderpoori ◽  
...  
Keyword(s):  
Drinking Water ◽  
Dose Response ◽  
Meta Analysis ◽  
Arsenic Exposure

scholarly journals Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach

2019 ◽  
Vol 49 (1) ◽  
pp. 36-84 ◽  
Author(s):  
Joyce S. Tsuji ◽  
Ellen T. Chang ◽  
P. Robinan Gentry ◽  
Harvey J. Clewell ◽  
Paolo Boffetta ◽  
...  
Keyword(s):  
Drinking Water ◽  
Cancer Risk ◽  
Dose Response ◽  
Inorganic Arsenic ◽  
Scientific Basis ◽  
Threshold Approach

QMRA for Drinking Water: 2. The Effect of Pathogen Clustering in Single-Hit Dose-Response Models

Risk Analysis ◽  
2016 ◽  
Vol 36 (1) ◽  
pp. 163-181 ◽  
Author(s):  
Vegard Nilsen ◽  
John Wyller
Keyword(s):  
Drinking Water ◽  
Dose Response ◽  
Response Models

scholarly journals Equivalent intraperitoneal doses of ibuprofen supplemented in drinking water or in diet: a behavioral and biochemical assay using antinociceptive and thromboxane inhibitory dose–response curves in mice

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2239 ◽  
Author(s):  
Raghda A.M. Salama ◽  
Nesreen H. El Gayar ◽  
Sonia S. Georgy ◽  
May Hamza
Keyword(s):  
Drinking Water ◽  
Dose Response ◽  
Formalin Test ◽  
Response Curves ◽  
Time Curve ◽  
Pain Model ◽  
Threshold Time ◽  
Dose Response Curves ◽  
Inhibitory Agents ◽  
Incisional Pain

Background.Ibuprofen is used chronically in different animal models of inflammation by administration in drinking water or in diet due to its short half-life. Though this practice has been used for years, ibuprofen doses were never assayed against parenteral dose–response curves. This study aims at identifying the equivalent intraperitoneal (i.p.) doses of ibuprofen, when it is administered in drinking water or in diet.Methods.Bioassays were performed using formalin test and incisional pain model for antinociceptive efficacy and serum TXB2for eicosanoid inhibitory activity. The dose–response curve of i.p. administered ibuprofen was constructed for each test using 50, 75, 100 and 200 mg/kg body weight (b.w.). The dose–response curves were constructed of phase 2a of the formalin test (the most sensitive phase to COX inhibitory agents), the area under the ‘change in mechanical threshold’-time curve in the incisional pain model and serum TXB2levels. The assayed ibuprofen concentrations administered in drinking water were 0.2, 0.35, 0.6 mg/ml and those administered in diet were 82, 263, 375 mg/kg diet.Results.The 3 concentrations applied in drinking water lay between 73.6 and 85.5 mg/kg b.w., i.p., in case of the formalin test; between 58.9 and 77.8 mg/kg b.w., i.p., in case of the incisional pain model; and between 71.8 and 125.8 mg/kg b.w., i.p., in case of serum TXB2levels. The 3 concentrations administered in diet lay between 67.6 and 83.8 mg/kg b.w., i.p., in case of the formalin test; between 52.7 and 68.6 mg/kg b.w., i.p., in case of the incisional pain model; and between 63.6 and 92.5 mg/kg b.w., i.p., in case of serum TXB2levels.Discussion.The increment in pharmacological effects of different doses of continuously administered ibuprofen in drinking water or diet do not parallel those of i.p. administered ibuprofen. It is therefore difficult to assume the equivalent parenteral daily doses based on mathematical calculations.

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