scholarly journals Inorganic Arsenic in Drinking Water and Bladder Cancer: A Meta-Analysis for Dose-Response Assessment

Author(s):  
Huei-An Chu ◽  
Douglas Crawford-Brown
2018 ◽  
Vol 7 (6) ◽  
pp. 1257-1266 ◽  
Author(s):  
Tanwei Yuan ◽  
Hongbo zhang ◽  
Bin Chen ◽  
Hong Zhang ◽  
Shasha Tao

High dose arsenic in drinking water (≥100 μg L−1) is known to induce lung cancer, but lung cancer risks at low to moderate arsenic levels and its dose–response relationship remains inconclusive.


Dose-Response ◽  
2019 ◽  
Vol 17 (3) ◽  
pp. 155932581986363 ◽  
Author(s):  
Paolo Boffetta ◽  
Claire Borron

Background: Exposure to high levels of arsenic in drinking water has been associated with an increased risk of lung and bladder cancer, but the presence of an increased risk at low levels is questionable. Methods: A systematic review and a dose–response meta-analysis were conducted on risk estimates of lung and bladder cancer for exposure to arsenic in drinking water up to 150 µg/L, using a 2-stage approach based on a random-effects model. Results: Five studies of lung cancer were identified; the meta-relative risk (RR) for an increase of 10 µg/L arsenic level was 1.03 (95% confidence interval [CI]: 0.99-1.06; P heterogeneity = .05). The meta-analysis of bladder cancer included 8 studies; the meta-RR for an increase of 10 µg/L arsenic level was 1.02 (95% CI: 0.97-1.07, P heterogeneity = .01). Sensitivity analyses, including a 1-stage meta-regression, confirmed the main findings. Conclusion: This systematic review and meta-analysis provided evidence of a lack of an increased risk of lung and bladder cancer for exposure to arsenic in drinking water up to 150 µg/L, the highest concentration studied.


Heliyon ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. e06409
Author(s):  
Afsaneh Amiri ◽  
Yaser Mokhayeri ◽  
Rasool Mohammadi ◽  
Mohammad Amin Karami ◽  
Mansour Ghaderpoori ◽  
...  

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Fuqiang Chen ◽  
Qingshu Li ◽  
Yang Yu ◽  
Wenrong Yang ◽  
Fei Shi ◽  
...  

2019 ◽  
Vol 49 (1) ◽  
pp. 36-84 ◽  
Author(s):  
Joyce S. Tsuji ◽  
Ellen T. Chang ◽  
P. Robinan Gentry ◽  
Harvey J. Clewell ◽  
Paolo Boffetta ◽  
...  

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