Butyrophilin and xanthine oxidase occur in constant molar proportions in milk lipid globule membrane but vary in amount with breed and stage of lactation

PROTOPLASMA ◽  
1993 ◽  
Vol 177 (1-2) ◽  
pp. 32-36 ◽  
Author(s):  
Bernadette L. Mondy ◽  
T. W. Keenan
Keyword(s):  
Xanthine Oxidase ◽  
Milk Lipid ◽  
Stage Of Lactation ◽  
Lipid Globule

Butyrophilin of milk lipid globule membrane contains N-linked carbohydrates and cross-links with xanthine oxidase

1989 ◽  
Vol 21 (1) ◽  
pp. 103-107 ◽  
Author(s):  
H.Mohammed Valivullah ◽  
T.W. Keenan
Keyword(s):  
Xanthine Oxidase ◽  
Milk Lipid ◽  
Lipid Globule ◽  
Cross Links

Comparison of lectin receptor and membrane coat-associated glycoproteins of milk lipid globule membranes

1979 ◽  
Vol 63 (1) ◽  
pp. 137-145 ◽  
Author(s):  
Lynne R. Murray ◽  
Karen M. Powell ◽  
M. Sasaki ◽  
W.N. Eigel ◽  
T.W. Keenan
Keyword(s):  
Milk Lipid ◽  
Lectin Receptor ◽  
Lipid Globule

scholarly journals Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane

1996 ◽  
Vol 320 (3) ◽  
pp. 1025-1030 ◽  
Author(s):  
Hans W. HEID ◽  
Martina SCHNÖLZER ◽  
Thomas W. KEENAN
Keyword(s):  
Adipocyte Differentiation ◽  
Sequence Similarity ◽  
Surface Membrane ◽  
Major Constituent ◽  
Milk Lipid ◽  
Related Protein ◽  
Membrane Material ◽  
Lipid Globule ◽  
Lactating Mammary Gland

Milk lipid globules from humans, cows and rats contained a protein identified as adipocyte differentiation-related protein (ADRP) associated with the globule surface membrane material. This protein, previously believed to be specific to adipocytes, was a major constituent of the globule surface and was present in a detergent-insoluble complex that contained stoichiometric amounts of butyrophilin and xanthine oxidase. Identification of ADRP was by sequence similarity of tryptic peptides from cow and human proteins with the sequence inferred from the cDNA for mouse ADRP. The putative ADRP of lipid globules from cow, human and rat milk was recognized specifically by antisera raised against a peptide synthesized to duplicate the N-terminal 26 residues of the mouse protein. In homogenates of lactating mammary gland, ADRP was found only in endoplasmic reticulum and in lipid droplet fractions. ADRP was modified, apparently post-translationally, and one modification apparently was acylation, primarily with C14, C16 and C18 fatty acids. Two isoelectric variants of ADRP were present in cow globule membrane material. In vitro, ADRP served as a substrate for protein kinases associated with milk lipid globule membrane, but this protein did not seem to become phosphorylated intracellularly.

Origin and Nature of the Milk Lipid Globule Membrane

1991 ◽  
pp. 117-129
Author(s):  
Thomas W. Keenan ◽  
Daniel P. Dylewski
Keyword(s):  
Milk Lipid ◽  
Lipid Globule

scholarly journals Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells

2003 ◽  
Vol 270 (6) ◽  
pp. 1176-1188 ◽  
Author(s):  
Nandor G. Than ◽  
Balazs Sumegi ◽  
Szabolcs Bellyei ◽  
Timea Berki ◽  
Gyorgy Szekeres ◽  
...  
Keyword(s):  
Lipid Droplet ◽  
Cervical Carcinoma ◽  
Carcinoma Cells ◽  
Milk Lipid ◽  
Lipid Globule ◽  
Placental Protein

scholarly journals Maternal protein reserves and their influence on lactational performance in rats 3. The effects of dietary protein restriction and stage of lactation on milk composition

1994 ◽  
Vol 72 (6) ◽  
pp. 815-830 ◽  
Author(s):  
A.P. Pine ◽  
N.S. Jessop ◽  
J.D. Oldham
Keyword(s):  
Dietary Protein ◽  
Protein Concentration ◽  
Milk Protein ◽  
Dietary Treatment ◽  
Milk Composition ◽  
Protein Restriction ◽  
Milk Lipid ◽  
Lipid Concentration ◽  
Dietary Protein Restriction ◽  
Stage Of Lactation

The effects of severe protein restriction following parturition on the changes in rat milk composition during lactation were investigated using multiparous female Sprague-Dawley rats caged individually following mating and offered a high-protein diet (H; 215 g crude protein (N × 6·25; CP)/kg dry matter (DM)) ad lib. until parturition. Following parturition, half the females continued to receive diet H, whilst the remainder were offered a diet low in protein (L; 90 g CP/kg DM) ad lib. On days 2, 4, 8 and 12 of lactation groups of females from both dietary treatments were used to provide a milk sample. Milk samples were analysed for their lactose (enzymically), protein (binding to Coomassie blue), lipid (gravimetrically) and mineral (spectrophotometrically) contents. The milk lactose concentration of group H increased with stage of lactation (r2 0·85, P < 0·001). Such an increase was prevented by diet L, and from day 8 of lactation the milk lactose of group L was lower (P < 0·05) than in group H. Group H milk protein concentration did not change during lactation and averaged 90·7 mg/g. Dietary protein restriction reduced the milk protein concentration of group L so that on days 2, 4 and 12 of lactation it was lower (P < 0·05) than that of group H. On day 8 of lactation the milk protein concentration of group L had increased (P < 0·05) and was comparable with that of group H. For group H, milk lipid averaged 166·8 mg/g and was generally unchanged during lactation. Diet L increased (P < 0·01) the milk lipid concentration (205·5 mg/g) compared with diet H and this was also significant on days 4 and 8 of lactation (P < 0·05). Group L milk lipid concentration also increased between days 4 and 8 of lactation (P < 0·05). Milk Na concentration declined during lactation in both dietary groups (P < 0·01) but was unaffected by dietary treatment. Both milk Ca and P concentrations increased (P < 0·01) during lactation in both dietary groups, whilst protein restriction also increased the Ca and P concentrations (P < 0·05). Milk K and Mg concentrations were unaffected by dietary treatment or stage of lactation. This significant alteration in the milk composition of severely protein-restricted dams, while possibly favouring the disposal of greater quantities of energy-yielding nutrients, suggests that equations developed for the estimation of milk production in rats cannot be used under such conditions. Laction: Milk composition: Feed intake: Dietary protien: Rat

Author response for "A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly‐sensitive assay"

2019 ◽  
Author(s):  
Noboru Hokama ◽  
Takashi Shirakura ◽  
Sumito Sunagawa ◽  
Satoko Morishima ◽  
Sawako Nakachi ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Oxidase Activity ◽  
Hematological Malignancies ◽  
Author Response ◽  
Sensitive Assay ◽  
Xanthine Oxidase Activity ◽  
Highly Sensitive

Screening of Hungarian mushrooms for xanthine-oxidase inhibitory activity

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
A Ványolós ◽  
O Orbán-Gyapai ◽  
T Támadi ◽  
J Hohmann
Keyword(s):  
Xanthine Oxidase ◽  
Inhibitory Activity
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