Deletion and hypermethylation of thymidine kinase gene in V79 Chinese hamster cells resistant to bromodeoxyuridine

1988 ◽  
Vol 14 (6) ◽  
pp. 567-581 ◽  
Author(s):  
Thomas L. Wise ◽  
Morgan Harris
Keyword(s):  
Thymidine Kinase ◽  
Chinese Hamster ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Chinese Hamster Cells

Map location of the thymidine kinase gene of bovine herpesvirus 1.

1987 ◽  
Vol 61 (12) ◽  
pp. 4023-4025 ◽  
Author(s):  
L J Bello ◽  
J C Whitbeck ◽  
W C Lawrence
Keyword(s):  
Thymidine Kinase ◽  
Bovine Herpesvirus ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1 ◽  
Map Location

scholarly journals G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter.

1994 ◽  
Vol 269 (2) ◽  
pp. 1306-1313
Author(s):  
Q.P. Dou ◽  
S. Zhao ◽  
A.H. Levin ◽  
J. Wang ◽  
K. Helin ◽  
...  
Keyword(s):  
Thymidine Kinase ◽  
Protein Complexes ◽  
Gene Promoter ◽  
Thymidine Kinase Gene ◽  
Kinase Gene

scholarly journals Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1

1979 ◽  
Vol 7 (4) ◽  
pp. 859-878 ◽  
Author(s):  
N.M. Wilkie ◽  
J.B. Clements ◽  
W. Boll ◽  
N. Mantei ◽  
D. Lonsdale ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Thymidine Kinase ◽  
Thymidine Kinase Gene ◽  
Herpes Simplex Virus 1 ◽  
Kinase Gene ◽  
Simplex Virus

scholarly journals Genetic analysis of the human thymidine kinase gene promoter.

1986 ◽  
Vol 6 (8) ◽  
pp. 2903-2909 ◽  
Author(s):  
J A Kreidberg ◽  
T J Kelly
Keyword(s):  
Thymidine Kinase ◽  
Base Pair ◽  
Promoter Region ◽  
Genomic Sequence ◽  
Gene Promoter ◽  
Thymidine Kinase Gene ◽  
Rich Region ◽  
Kinase Gene ◽  
Inverted Orientation ◽  
Pair Sequence

The promoter of the human thymidine kinase gene was defined by DNA sequence and genetic analyses. Mutant plasmids with deletions extending into the promoter region from both the 5' and 3' directions were constructed. The mutants were tested in a gene transfer system for the ability to transform TK- cells to the TK+ phenotype. This analysis delimited the functional promoter to within an 83-base-pair region upstream of the mRNA cap site. This region contains sequences common to other eucaryotic promoters including G X C-rich hexanucleotides, a CAAT box, and an A X T-rich region. The CAAT box is in an inverted orientation and is part of a 9-base-pair sequence repeated twice in the promoter region. Comparison of the genomic sequence with the cDNA sequence defined the first exon of the thymidine kinase gene.

Are hepatomas a good target for suicide gene therapy? An experimental study in rats using retroviral-mediated transfer of thymidine kinase gene

Surgery ◽  
1998 ◽  
Vol 123 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Héléna Nagy ◽  
Yves Panis ◽  
Monique Fabre ◽  
Hubert Perrin ◽  
David Klatzmann ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Experimental Study ◽  
Thymidine Kinase ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Good Target

Experimental study of thymidine kinase gene therapy of neuroblastoma in vitro and in vivo

2003 ◽  
Vol 19 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Xun Bi ◽  
Jing-Zhe Zhang
Keyword(s):  
Gene Therapy ◽  
Experimental Study ◽  
Thymidine Kinase ◽  
Thymidine Kinase Gene ◽  
Kinase Gene

Adenoviral-Mediated Herpes Simplex Virus Thymidine Kinase Gene Transfer

Pancreas ◽  
1997 ◽  
Vol 15 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Andreas Block ◽  
Shu-Hsia Chen ◽  
Ken-Ichiro Kosai ◽  
Milton Finegold ◽  
Savio L. C. Woo
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Gene Transfer ◽  
Thymidine Kinase ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Simplex Virus

Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene

1991 ◽  
Vol 11 (6) ◽  
pp. 3374-3378 ◽  
Author(s):  
S D Lupton ◽  
L L Brunton ◽  
V A Kalberg ◽  
R W Overell
Keyword(s):  
Thymidine Kinase ◽  
Negative Selection ◽  
Fusion Gene ◽  
Hygromycin B ◽  
Thymidine Kinase Gene ◽  
Kinase Gene ◽  
Hygromycin Phosphotransferase ◽  
Simplex Virus ◽  
Genetic Entity

The hygromycin phosphotransferase gene was fused in-frame with the herpes simplex virus type 1 thymidine kinase gene. The resulting fusion gene (termed HyTK) confers hygromycin B resistance for dominant positive selection and ganciclovir sensitivity for negative selection and provides a means by which these selectable phenotypes may be expressed and regulated as a single genetic entity.

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