Site differences in human subcutaneous adipose tissue metabolism in obesity

1984 ◽  
Vol 8 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Peter Arner
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Subcutaneous Adipose

scholarly journals Autologous subcutaneous adipose tissue transplants improve adipose tissue metabolism and reduce insulin resistance and fatty liver in diet-induced obesity rats

2016 ◽  
Vol 4 (17) ◽  
pp. e12909 ◽  
Author(s):  
Gonzalo Torres-Villalobos ◽  
Nashla Hamdan-Pérez ◽  
Andrea Díaz-Villaseñor ◽  
Armando R. Tovar ◽  
Ivan Torre-Villalvazo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Fatty Liver ◽  
Subcutaneous Adipose Tissue ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Diet Induced Obesity ◽  
Tissue Transplants ◽  
Reduce Insulin Resistance ◽  
Subcutaneous Adipose

scholarly journals Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes

Diabetes ◽  
2010 ◽  
Vol 59 (11) ◽  
pp. 2790-2798 ◽  
Author(s):  
L. Hojbjerre ◽  
M. P. Sonne ◽  
A. C. Alibegovic ◽  
F. Dela ◽  
A. Vaag ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Physical Inactivity ◽  
Young Male ◽  
Male Offspring ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Subcutaneous Adipose

Effect of fish-meal supplementation and β-agonist administration on adipose tissue metabolism in steers given silage

1993 ◽  
Vol 57 (03) ◽  
pp. 397-406
Author(s):  
J. M. Dawson ◽  
C. P. Essex ◽  
A. Walsh ◽  
D. E. Beever ◽  
M. Gill ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Fish Meal ◽  
Live Weight ◽  
Substrate Oxidation ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Oxidation Rates ◽  
Subcutaneous Adipose

AbstractThe effect of fish-meal supplementation or cimaterol administration on the composition, cellularity and metabolism of subcutaneous and perirenal adipose tissue was examined in young Friesian steers given grass silage. Animals (approx. 117 kg live weight) received either silage alone (group C; no. = 6) or supplemented with fish meal (150 g/kg silage dry matter; group FM; no. = 6) or cimaterol (0·06 mg/kg body weight per day) administered via osmotic minipumps (group CIM; no. = 6) for a period of 6 weeks. Samples of perirenal and subcutaneous adipose tissue obtained at slaughter were used for determination of tissue composition andin vitrorates of lipogenesis, lipolysis and substrate oxidation. FM animals showed significantly greater live-weight gains (0·61 kg/day) compared with C (0·21 kg/day,P< 0·001) while CIM animals had significantly lower rates of gain (0·04 kg/day,P< 0·05). This was considered to be related to increased heat loss from the β-agonist-treated animals as a result of very cold weather encountered during the experimental period. CIM administration reduced adipocyte size suggesting an increased number of cells per g tissue. Both lipolytic and lipogenic rates were reduced by cimaterol and there was some evidence that the response to insulin was diminished, at least with respect to substrate oxidation. FM increased lipogenesis from acetate and acetate oxidation rates in subcutaneous adipose tissue with similar trends in perirenal tissue. The results indicate that both fish-meal supplementation and cimaterol administration caused substantial changes in adipose tissue metabolism as determined usingin vitroprocedures, even though the magnitude and direction of the changes were not in strict accord with estimates of net fat accretion from relatedin vivostudies.

scholarly journals Subcutaneous Adipose Tissue Metabolism at Menopause: Importance of Body Fatness and Regional Fat Distribution1

2000 ◽  
Vol 85 (7) ◽  
pp. 2446-2454
Author(s):  
P. Mauriège ◽  
P. Imbeault ◽  
D. Prud’homme ◽  
A. Tremblay ◽  
A. Nadeau ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Body Fatness ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Subcutaneous Adipose

scholarly journals Effects of second-generation antipsychotics on human subcutaneous adipose tissue metabolism

2019 ◽  
Vol 110 ◽  
pp. 104445 ◽  
Author(s):  
Assel Sarsenbayeva ◽  
Cátia M. Marques-Santos ◽  
Ketan Thombare ◽  
Giada Di Nunzio ◽  
Kristina E. Almby ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Second Generation ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Second Generation Antipsychotics ◽  
Subcutaneous Adipose

scholarly journals Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness

Metabolites ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 62 ◽  
Author(s):  
Ioannis Ilias ◽  
Sofia Apollonatou ◽  
Nikitas Nikitas ◽  
Maria Theodorakopoulou ◽  
Alice G. Vassiliou ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mitochondrial Dysfunction ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Treatment Strategies ◽  
Adipose Tissue Metabolism ◽  
Icu Admission ◽  
Tissue Metabolism ◽  
Poor Outcome ◽  
Subcutaneous Adipose

Microdialysis (MD) can provide continuous information about tissue composition. To assess in critically ill patients adipose tissue metabolic patterns, the relationships between metabolic patterns and blood cytokine concentration associations of adipose tissue energy metabolism and clinical outcome we studied 203 mechanically ventilated general intensive care unit (ICU) patients. Upon ICU admission an MD catheter was inserted into the subcutaneous adipose tissue of the upper thigh to measure lactate (L), glucose, pyruvate (P), and glycerol. Serum concentrations of IL-10, IL-6, IL-8, and TNF-α were determined within 48 h from ICU admission. Mitochondrial dysfunction was defined as L/P ratio >30 and pyruvate ≥70 μmol/L, ischemia as L/P ratio >30 and pyruvate <70 μmol/L and no ischemia/no mitochondrial dysfunction (i.e. aerobic metabolism) was as L/P ratio ≤30. Metabolism was aerobic in 74% of patients. In 13% of patients there was biochemical evidence of ischemia and in 13% of patients of mitochondrial dysfunction. Mitochondrial dysfunction was associated with poor outcome. In conclusion, MD showed that about two thirds of critically ill patients have normal aerobic adipose tissue metabolism. Mitochondrial dysfunction was not common but was associated with poor outcome. Identifying subgroups of critically ill patients is crucial as different treatment strategies may improve survival.

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