scholarly journals Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes

Diabetes ◽  
2010 ◽  
Vol 59 (11) ◽  
pp. 2790-2798 ◽  
Author(s):  
L. Hojbjerre ◽  
M. P. Sonne ◽  
A. C. Alibegovic ◽  
F. Dela ◽  
A. Vaag ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Physical Inactivity ◽  
Young Male ◽  
Male Offspring ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Subcutaneous Adipose

scholarly journals The Mineralocorticoid Receptor Antagonist Eplerenone Suppress Interstitial Fibrosis in Subcutaneous Adipose Tissue in Type 2 Diabetes Patients

2020 ◽  
Author(s):  
Ada Admin ◽  
Marie Louise Johansen ◽  
Jaime Ibarrola ◽  
Amaya Fernández-Celis ◽  
Morten Schou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Receptor Antagonist ◽  
Subcutaneous Adipose Tissue ◽  
Mineralocorticoid Receptor ◽  
Prostaglandin D2 ◽  
Type I ◽  
Mineralocorticoid Receptor Antagonist ◽  
Subcutaneous Adipose

Activation of the mineralocorticoid receptor (MR) may promote dysfunctional adipose tissue in patients with type 2 diabetes, where increased pericellular fibrosis has emerged as a major contributor. The knowledge of the association between the MR, fibrosis and the effects of an MR antagonist (MRA) in human adipocytes remains very limited. The present sub-study including 30 participants was prespecified as part of the Mineralocorticoid Receptor Antagonist in type 2 Diabetes (MIRAD) trial, randomizing patients to either high dose eplerenone or placebo for 26 weeks. In adipose tissue biopsies, changes in fibrosis were evaluated by immunohistological examinations and by the expression of mRNA and protein markers of fibrosis. Treatment with an MRA reduced pericellular fibrosis, synthesis of the major subunits of collagen type I and VI, and the profibrotic factor α-smooth muscle actin, as compared to placebo in subcutaneous adipose tissue. Furthermore, we found decreased expression of the MR and downstream molecules neutrophil gelatinase–associated lipocalin, galectin-3, and lipocalin-like prostaglandin D2 synthase with an MRA. In conclusions, we present original data demonstrating reduced fibrosis in adipose tissue with inhibition of the MR, which could be a potential therapeutic approach to prevent the extracellular matrix remodeling of adipose tissue in type 2 diabetes.

scholarly journals Autologous subcutaneous adipose tissue transplants improve adipose tissue metabolism and reduce insulin resistance and fatty liver in diet-induced obesity rats

2016 ◽  
Vol 4 (17) ◽  
pp. e12909 ◽  
Author(s):  
Gonzalo Torres-Villalobos ◽  
Nashla Hamdan-Pérez ◽  
Andrea Díaz-Villaseñor ◽  
Armando R. Tovar ◽  
Ivan Torre-Villalvazo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Fatty Liver ◽  
Subcutaneous Adipose Tissue ◽  
Adipose Tissue Metabolism ◽  
Tissue Metabolism ◽  
Diet Induced Obesity ◽  
Tissue Transplants ◽  
Reduce Insulin Resistance ◽  
Subcutaneous Adipose

scholarly journals The Mineralocorticoid Receptor Antagonist Eplerenone Suppresses Interstitial Fibrosis in Subcutaneous Adipose Tissue in Patients With Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 70 (1) ◽  
pp. 196-203
Author(s):  
Marie Louise Johansen ◽  
Jaime Ibarrola ◽  
Amaya Fernández-Celis ◽  
Morten Schou ◽  
Mette Pauli Sonne ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Receptor Antagonist ◽  
Subcutaneous Adipose Tissue ◽  
Mineralocorticoid Receptor ◽  
Interstitial Fibrosis ◽  
Mineralocorticoid Receptor Antagonist ◽  
Subcutaneous Adipose

Human subcutaneous adipose tissue Glut 4 mRNA expression in obesity and type 2 diabetes

2011 ◽  
Vol 50 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Soumaya Kouidhi ◽  
Rym Berrhouma ◽  
Kamel Rouissi ◽  
Slim Jarboui ◽  
Marie-Stéphanie Clerget-Froidevaux ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Mrna Expression ◽  
Subcutaneous Adipose Tissue ◽  
Glut 4 ◽  
Subcutaneous Adipose

Lower Stearoyl-CoA Desaturase and Hormone Sensitive Lipase Gene Expression in Superficial Subcutaneous Adipose Tissue of Male, but Not Female, Patients with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2054-P
Author(s):  
KÁLMÁN BÓDIS ◽  
JESPER LUNDBOM ◽  
TOMAS JELENIK ◽  
DANIEL F. MARKGRAF ◽  
ALEXANDER STROM ◽  
...  
Keyword(s):  
Gene Expression ◽  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Hormone Sensitive Lipase ◽  
Lipase Gene ◽  
Hormone Sensitive ◽  
Stearoyl Coa Desaturase ◽  
Subcutaneous Adipose

2313-PUB: Alterations in Basal State of Insulin and mTOR-Dependent Signalings Closely Related to Impaired Incretin Profile and Type 2 Diabetes in Subcutaneous Adipose Tissue of Obese Patients

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2313-PUB
Author(s):  
IURII STAFEEV ◽  
IGOR SKLYANIK ◽  
SVETLANA MICHURINA ◽  
EKATERINA SHESTAKOVA ◽  
ANATOLIY YURASOV ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Obese Patients ◽  
Subcutaneous Adipose

scholarly journals Decreased Expression Of apM1 in Omental and Subcutaneous Adipose Tissue of Humans With Type 2 Diabetes

2000 ◽  
Vol 1 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Michael A. Statnick ◽  
Lisa S. Beavers ◽  
Laura J. Conner ◽  
Helena Corominola ◽  
Dwayne Johnson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Diabetic Patients ◽  
Mrna Levels ◽  
Type 2 Diabetic Patients ◽  
Omental Adipose Tissue ◽  
Subcutaneous Adipose ◽  
Type 2 Diabetic

We have screened a subtracted cDNA library in order to identify differentially expressed genes in omental adipose tissue of human patients with Type 2 diabetes. One clone (#1738) showed a marked reduction in omental adipose tissue from patients with Type 2 diabetes. Sequencing and BLAST analysis revealed clone #1738 was the adipocyte-specific secreted protein gene apM1 (synonyms ACRP30, AdipoQ, GBP28). Consistent with the murine orthologue, apM1 mRNA was expressed in cultured human adipocytes and not in preadipocytes. Using RT-PCR we confirmed that apM1 mRNA levels were significantly reduced in omental adipose tissue of obese patients with Type 2 diabetes compared with lean and obese normoglycemic subjects. Although less pronounced, apM1 mRNA levels were reduced in subcutaneous adipose tissue of Type 2 diabetic patients. Whereas the biological function of apM1 is presently unknown, the tissue specific expression, structural similarities to TNFα and the dysregulated expression observed in obese Type 2 diabetic patients suggest that this factor may play a role in the pathogenesis of insulin resistance and Type 2 diabetes.

TCF7L2 gene expression in human visceral and subcutaneous adipose tissue is differentially regulated but not associated with type 2 diabetes mellitus

Metabolism ◽  
2008 ◽  
Vol 57 (9) ◽  
pp. 1227-1231 ◽  
Author(s):  
Peter Kovacs ◽  
Janin Berndt ◽  
Karen Ruschke ◽  
Nora Klöting ◽  
Michael R. Schön ◽  
...  
Keyword(s):  
Gene Expression ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Tcf7l2 Gene ◽  
Subcutaneous Adipose
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