Involvement of brain serotonergic system in the antinociceptive action of acetylsalicylic acid in the rat

1995 ◽  
Vol 44 (1) ◽  
pp. 30-35 ◽  
Author(s):  
L. A. Pini ◽  
M. Sandrini ◽  
G. Vitale
Keyword(s):  
Acetylsalicylic Acid ◽  
Serotonergic System ◽  
Antinociceptive Action

Acetylsalicylic acid potentiates the antinociceptive effect of morphine in the rat: involvement of the central serotonergic system

1998 ◽  
Vol 355 (2-3) ◽  
pp. 133-140 ◽  
Author(s):  
Maurizio Sandrini ◽  
Alessandra Ottani ◽  
Giovanni Vitale ◽  
Luigi Alberto Pini
Keyword(s):  
Acetylsalicylic Acid ◽  
Antinociceptive Effect ◽  
Serotonergic System

The antinociceptive effect of acetylsalicylic acid is differently affected by a CB1 agonist or antagonist and involves the serotonergic system in rats

Life Sciences ◽  
2010 ◽  
Vol 86 (13-14) ◽  
pp. 510-517 ◽  
Author(s):  
Valentina Ruggieri ◽  
Giovanni Vitale ◽  
Monica Filaferro ◽  
Claudio Frigeri ◽  
Luigi A. Pini ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Antinociceptive Effect ◽  
Serotonergic System

Lymphocyte Membrane Modifications induced by Acetylsalicylic Acid and Dipyridamole

1976 ◽  
Vol 36 (01) ◽  
pp. 293-295 ◽  
Author(s):  
E Coeugniet ◽  
A Dirksen
Keyword(s):  
Acetylsalicylic Acid ◽  
Lymphocyte Membrane

Inhibition of Human and Animal Platelet Adhesiveness to Glass Bead Columns by Adenosine, Dipyridamole, Chlorpromazine and Acetylsalicylic Acid

1976 ◽  
Vol 36 (02) ◽  
pp. 401-410 ◽  
Author(s):  
Buichi Fujttani ◽  
Toshimichi Tsuboi ◽  
Kazuko Takeno ◽  
Kouichi Yoshida ◽  
Masanao Shimizu
Keyword(s):  
Guinea Pig ◽  
Acetylsalicylic Acid ◽  
Guinea Pigs ◽  
Glass Bead ◽  
Animal Species ◽  
Inhibitory Effect ◽  
Rabbit Platelet ◽  
Platelet Adhesiveness

SummaryThe differences among human, rabbit and guinea-pig platelet adhesiveness as for inhibitions by adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid are described, and the influence of measurement conditions on platelet adhesiveness is also reported. Platelet adhesiveness of human and animal species decreased with an increase of heparin concentrations and an increase of flow rate of blood passing through a glass bead column. Human and rabbit platelet adhesiveness was inhibited in vitro by adenosine, dipyridamole and chlorpromazine, but not by acetylsalicylic acid. On the other hand, guinea-pig platelet adhesiveness was inhibited by the four drugs including acetylsalicylic acid. In in vivo study, adenosine, dipyridamole and chlorpromazine inhibited platelet adhesiveness in rabbits and guinea-pigs. Acetylsalicylic acid showed the inhibitory effect in guinea-pigs, but not in rabbits.

Sulfinpyrazone or Acetylsalicylic Acid to Prevent Postoperative Thrombus Formation in Arteriovenous Fistulas of Haemodialysis Patients

1979 ◽  
Author(s):  
F Albert ◽  
U Schmidt
Keyword(s):  
Side Effects ◽  
Acetylsalicylic Acid ◽  
Thrombus Formation ◽  
Significant Inhibition ◽  
High Rate ◽  
Controlled Clinical Trial ◽  
Arteriovenous Fistulas ◽  
Arteriovenous Shunts ◽  
Gastrointestinal Side Effects ◽  
Antithrombotic Efficacy

The effect of sulfinpyrazone (200 mg three times a day) and acetylsalicylic acid (500 mg three times a day) on the incidence of thrombosis of arteriovenous shunts was investigated in a controlled clinical trial. In 36 patients with chronic renal failure scheduled to begin haemodialysis the same operating team constructed a subcutaneous fistula in the distal forearm. During the first six weeks after the operation the antithrombotic efficacy proved to be good for both substances. No differences of thrombotic events between the two treatment groups were statistically significant. But in contrast to acetylsalicylic acid sulfinpyrazone made no significant inhibition of platelet - aggregation; sulfinpyrazone probably will prevent the clot formation by prolonging the shortened platelet survival in uraemic patients. In a high rate of patients given acetylsalicylic acid (10 out of 17) there were local bleeding and gastrointestinal side effects. In consequence we should prefer sulfinpyrazone, because in the sulfinpyrazone group side effects were minimal and in none patient withdrawal from the study was necessitated.

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