The antinociceptive effect of acetylsalicylic acid is differently affected by a CB1 agonist or antagonist and involves the serotonergic system in rats

Life Sciences ◽  
2010 ◽  
Vol 86 (13-14) ◽  
pp. 510-517 ◽  
Author(s):  
Valentina Ruggieri ◽  
Giovanni Vitale ◽  
Monica Filaferro ◽  
Claudio Frigeri ◽  
Luigi A. Pini ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Antinociceptive Effect ◽  
Serotonergic System

Acetylsalicylic acid potentiates the antinociceptive effect of morphine in the rat: involvement of the central serotonergic system

1998 ◽  
Vol 355 (2-3) ◽  
pp. 133-140 ◽  
Author(s):  
Maurizio Sandrini ◽  
Alessandra Ottani ◽  
Giovanni Vitale ◽  
Luigi Alberto Pini
Keyword(s):  
Acetylsalicylic Acid ◽  
Antinociceptive Effect ◽  
Serotonergic System

scholarly journals EFFECT OF LYOPHILIZED JUICE OF PUNICA GRANATUM L. IN ANTINOCICEPTIVE AND INFLAMMATORY PAIN

2021 ◽  
pp. 17-19
Author(s):  
JOSE ANTONIO GUERRERO-SOLANO ◽  
MIRANDELI BAUTISTA ◽  
NELLY DEL SOCORRO CRUZ-CANSINO ◽  
ALEJANDRO CHEHUE-ROMERO ◽  
OSMAR ANTONIO JARAMILLO-MORALES
Keyword(s):  
Body Weight ◽  
Acetylsalicylic Acid ◽  
Inflammatory Pain ◽  
Wistar Rats ◽  
Formalin Test ◽  
Antinociceptive Effect ◽  
Punica Granatum ◽  
Reference Drug ◽  
Male Wistar Rats ◽  
Punica Granatum L

Objective: The aim of this study was to explore the analgesic activity of lyophilized juice of Punica granatum L., obtained from Hidalgo, Mexico, in theformalin test.Methods: We extracted the juice manually, filtered it and then dried down in a lyophilizer machine. We evaluated the antinociceptive effect oflyophilized juice from pomegranate in the formalin test (2%) in male Wistar rats (180–200 g body weight). Thirty minutes before the test, a dose of316 mg/kg (lyophilized juice) and acetylsalicylic acid as reference drug (100 mg/kg) both were administered intragastrically (i.g.).Results: The oral administration of lyophilized juice of pomegranate showed a significant decrease in the number of flinches in the temporal courseand a significant antinociceptive effect in nociceptive and inflammatory pain compared with the vehicle. In the same way, this effect appeared with thedrug of reference (acetylsalicylic acid 100 mg/kg i.g). Furthermore, it was shown that juice had a 34% of antinociception on overall effect versus vehicle.Conclusion: The results suggest that lyophilized juice of pomegranate has antinociceptive effect in nociceptive and inflammatory pain. Therefore, thisstudy supports the possible use of this lyophilized juice of pomegranate in the treatment of pain.

Serotonin and Opiate Involvement in the Antinociceptive Effect of Acetylsalicylic Acid

Pharmacology ◽  
1997 ◽  
Vol 54 (2) ◽  
pp. 84-91 ◽  
Author(s):  
L.-A. Pini ◽  
G. Vitale ◽  
M. Sandrini
Keyword(s):  
Acetylsalicylic Acid ◽  
Antinociceptive Effect

Antinociceptive effect of Allium schoenoprasum L. oral feeding in diabetic rats

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
M Roghani ◽  
T Baluchnejadmojarad ◽  
M Kord
Keyword(s):  
Antinociceptive Effect ◽  
Diabetic Rats ◽  
Oral Feeding ◽  
Allium Schoenoprasum

Lymphocyte Membrane Modifications induced by Acetylsalicylic Acid and Dipyridamole

1976 ◽  
Vol 36 (01) ◽  
pp. 293-295 ◽  
Author(s):  
E Coeugniet ◽  
A Dirksen
Keyword(s):  
Acetylsalicylic Acid ◽  
Lymphocyte Membrane

Inhibition of Human and Animal Platelet Adhesiveness to Glass Bead Columns by Adenosine, Dipyridamole, Chlorpromazine and Acetylsalicylic Acid

1976 ◽  
Vol 36 (02) ◽  
pp. 401-410 ◽  
Author(s):  
Buichi Fujttani ◽  
Toshimichi Tsuboi ◽  
Kazuko Takeno ◽  
Kouichi Yoshida ◽  
Masanao Shimizu
Keyword(s):  
Guinea Pig ◽  
Acetylsalicylic Acid ◽  
Guinea Pigs ◽  
Glass Bead ◽  
Animal Species ◽  
Inhibitory Effect ◽  
Rabbit Platelet ◽  
Platelet Adhesiveness

SummaryThe differences among human, rabbit and guinea-pig platelet adhesiveness as for inhibitions by adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid are described, and the influence of measurement conditions on platelet adhesiveness is also reported. Platelet adhesiveness of human and animal species decreased with an increase of heparin concentrations and an increase of flow rate of blood passing through a glass bead column. Human and rabbit platelet adhesiveness was inhibited in vitro by adenosine, dipyridamole and chlorpromazine, but not by acetylsalicylic acid. On the other hand, guinea-pig platelet adhesiveness was inhibited by the four drugs including acetylsalicylic acid. In in vivo study, adenosine, dipyridamole and chlorpromazine inhibited platelet adhesiveness in rabbits and guinea-pigs. Acetylsalicylic acid showed the inhibitory effect in guinea-pigs, but not in rabbits.

Sulfinpyrazone or Acetylsalicylic Acid to Prevent Postoperative Thrombus Formation in Arteriovenous Fistulas of Haemodialysis Patients

1979 ◽  
Author(s):  
F Albert ◽  
U Schmidt
Keyword(s):  
Side Effects ◽  
Acetylsalicylic Acid ◽  
Thrombus Formation ◽  
Significant Inhibition ◽  
High Rate ◽  
Controlled Clinical Trial ◽  
Arteriovenous Fistulas ◽  
Arteriovenous Shunts ◽  
Gastrointestinal Side Effects ◽  
Antithrombotic Efficacy

The effect of sulfinpyrazone (200 mg three times a day) and acetylsalicylic acid (500 mg three times a day) on the incidence of thrombosis of arteriovenous shunts was investigated in a controlled clinical trial. In 36 patients with chronic renal failure scheduled to begin haemodialysis the same operating team constructed a subcutaneous fistula in the distal forearm. During the first six weeks after the operation the antithrombotic efficacy proved to be good for both substances. No differences of thrombotic events between the two treatment groups were statistically significant. But in contrast to acetylsalicylic acid sulfinpyrazone made no significant inhibition of platelet - aggregation; sulfinpyrazone probably will prevent the clot formation by prolonging the shortened platelet survival in uraemic patients. In a high rate of patients given acetylsalicylic acid (10 out of 17) there were local bleeding and gastrointestinal side effects. In consequence we should prefer sulfinpyrazone, because in the sulfinpyrazone group side effects were minimal and in none patient withdrawal from the study was necessitated.

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