Lack of vasodilatory response in skeletal muscle blood vessels of aged spontaneously hypertensive rats

1996 ◽  
Vol 11 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Kunisuke Horiuchi ◽  
Hong He ◽  
Atsufumi Tomohiro ◽  
Yasuharu Aki ◽  
Shoji Kimura ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Vessels ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Vasodilatory Response

HISTOCHEMICAL AND STRUCTURAL ADAPTATION OF SKELETAL MUSCLE TO BODY SUSPENSION IN SPONTANEOUSLY HYPERTENSIVE RATS.

1995 ◽  
Vol 27 (Supplement) ◽  
pp. S181
Author(s):  
S. Ogoh ◽  
S. Yamasaki ◽  
H. Okamoto ◽  
S. Fukuda ◽  
S. Tsuchikura ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spontaneously Hypertensive Rats ◽  
Structural Adaptation ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Skeletal Muscle of Stroke-Prone Spontaneously Hypertensive Rats Exhibits Reduced Insulin-Stimulated Glucose Transport and Elevated Levels of Caveolin and Flotillin

Diabetes ◽  
2001 ◽  
Vol 50 (9) ◽  
pp. 2148-2156 ◽  
Author(s):  
D. J. James ◽  
F. Cairns ◽  
I. P. Salt ◽  
G. J. Murphy ◽  
A. F. Dominiczak ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Transport ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Increased DNA fragmentation and altered apoptotic protein levels in skeletal muscle of spontaneously hypertensive rats

2006 ◽  
Vol 101 (4) ◽  
pp. 1149-1161 ◽  
Author(s):  
Joe Quadrilatero ◽  
James W. E. Rush
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Dna Fragmentation ◽  
Spontaneously Hypertensive Rats ◽  
Heart Weight ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Apoptotic Signaling ◽  
Bax Protein

Apoptosis is a highly conserved process that plays an important role in controlling tissue development, homeostasis, and architecture. Dysregulation of apoptosis is a hallmark of numerous human pathologies including hypertension. In the present work we studied the effect of hypertension on apoptosis and the expression of several apoptotic signaling and/or regulatory proteins in four functionally and metabolically distinct muscles. Specifically, we examined these markers in soleus, red gastrocnemius, white gastrocnemius, and left ventricle (LV) of 20-wk-old normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Compared with WKY rats SHR had a significantly greater heart weight, LV weight, and mean arterial pressure. In general, SHR skeletal muscle had increased Bax protein, procaspase-3 protein, caspase-3 activity, cleaved poly(ADP-ribose) polymerase protein, and DNA fragmentation as well as decreased Bcl-2 protein and a lower Bcl-2-to-Bax ratio. Subcellular distribution studies demonstrated increased levels of apoptosis-inducing factor protein in cytosolic or nuclear extracts as well as elevated nuclear Bax protein in SHR skeletal muscle. Moreover, heat shock protein 70 in red gastrocnemius and soleus was significantly correlated to several apoptotic factors. With the exception of lower heat shock protein 90 levels in SHR no additional differences in any apoptotic markers were observed in LV between groups. Collectively, this report provides the first evidence that apoptotic signaling is altered in skeletal muscle of hypertensive animals, an effect that may be mediated by both caspase-dependent and -independent mechanisms. This proapoptotic state may provide some understanding for the morphological and functional abnormalities observed in skeletal muscle of hypertensive animals.

Evidence for Increased In Vivo Na+/K+-Atpase Activity in Skeletal Muscle of Spontaneously Hypertensive Rats

1990 ◽  
Vol 78 (s22) ◽  
pp. 8P-8P ◽  
Author(s):  
PD Syme ◽  
RM Dixon ◽  
JK Aronson ◽  
DG Grahame-Smith ◽  
GK Radda
Keyword(s):  
Skeletal Muscle ◽  
Atpase Activity ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
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