Monoclonal antibodies applied to primary human breast carcinoma: Relationship to menopausal status, lymph node status, and steroid hormone receptor content

1982 ◽  
Vol 2 (4) ◽  
pp. 401-405 ◽  
Author(s):  
Birgitte Bruun Rasmussen ◽  
John Hilkens ◽  
Jo Hilgers ◽  
Hans Henrik Nielsen ◽  
Susan M. Thorpe ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Hormone Receptor ◽  
Steroid Hormone ◽  
Menopausal Status ◽  
Lymph Node Status ◽  
Steroid Hormone Receptor ◽  
Human Breast ◽  
Primary Human Breast

Steroid hormone receptor activity of primary human breast cancer and pattern of first metastasis

1991 ◽  
Vol 18 (1) ◽  
pp. 27-32 ◽  
Author(s):  
P. G. Koenders ◽  
L. V. A. M. Beex ◽  
R. Langens ◽  
P. W. C. Kloppenborg ◽  
A. G. H. Smals ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Human Breast Cancer ◽  
Steroid Hormone ◽  
Receptor Activity ◽  
Steroid Hormone Receptor ◽  
Human Breast ◽  
Primary Human Breast

Steroid Hormone Receptor Content and Lymph Node Status in Endometrial Cancer

1995 ◽  
Vol 56 (3) ◽  
pp. 406-411 ◽  
Author(s):  
Peter C. Morris ◽  
James R. Anderson ◽  
Barrie Anderson ◽  
Richard E. Buller
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Hormone Receptor ◽  
Steroid Hormone ◽  
Lymph Node Status ◽  
Steroid Hormone Receptor ◽  
Node Status

scholarly journals Immunoradiometric assay of cathepsin D: Estrogen regulated vs. non estrogen- regulated cathepsin D expression in relation to clinicopathological features of breast cancer

2002 ◽  
Vol 10 (3) ◽  
pp. 115-117
Author(s):  
Dragica Nikolic-Vukosavljevic ◽  
Milan Markicevic ◽  
Ksenija Kanjer ◽  
Natasa Rakovic-Todorovic ◽  
Zora Neskovic-Konstantinovic
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Cathepsin D ◽  
Menopausal Status ◽  
Clinicopathological Features ◽  
Lymph Node Status ◽  
Immunoradiometric Assay ◽  
Node Status ◽  
Clinicopathological Findings

Background: Cellular biomarkers may predict tumor cell behavior in breast cancer. One of the most paradoxical biomarker in breast cancer is cathepsin D. Patients and methods: The study includes 152 patients with histologically verified breast carcinoma. Clinicopathological findings were classified according to classical breast carcinoma-host features (age and menopausal status) and carcinoma features (lymph node status, tumor size type and grade). Estrogen and progesterone receptors were assayed in accordance with the recommendation of the EORTC. Cathepsin D concentrations were determined using immunoradiometric assay. The results were analyzed using non-parametric statistical methods. Results: All differences in the proportion of breast carcinoma classified as cathepsin D-positive and disagreements on the association of cathepsin D status with clinicopathological features of breast cancer are the result of varying cut-off values used by different authors. Using the cut-off value, which defines estrogen-regulated vs. nonestrogen-regulated cathepsin D expres sion, this study points to the cathepsin D status as a complementary biolog ical information to ER and PR status, and a dependent biomarker in relation to age of patients and lymph node status. Conclusion: The classification of tumors according to the cathepsin D status within ER and PR status could provide more information on the association between cathepsin D status and clinical-pathological features of breast cancer.

Correlation of steroid hormone receptor levels with histological grading in human breast cancer

1980 ◽  
Vol 58 (12) ◽  
pp. 643-643 ◽  
Author(s):  
H. W�rz ◽  
P. Citoler ◽  
K. D. Schulz ◽  
B. Roos ◽  
R. Kaiser
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Human Breast Cancer ◽  
Steroid Hormone ◽  
Steroid Hormone Receptor ◽  
Human Breast ◽  
Histological Grading

Prognostic significance of cathepsins B and L in primary human breast cancer.

1998 ◽  
Vol 16 (3) ◽  
pp. 1013-1021 ◽  
Author(s):  
J A Foekens ◽  
J Kos ◽  
H A Peters ◽  
M Krasovec ◽  
M P Look ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Lymph Nodes ◽  
Hormone Receptor ◽  
Steroid Hormone ◽  
Menopausal Status ◽  
Hormone Receptor Status ◽  
Steroid Hormone Receptor ◽  
Receptor Status ◽  
Positive Lymph Nodes

PURPOSE Evaluation of the clinical significance of cytosolic tumor levels of the lysosomal cysteine proteases cathepsin B (catB) and cathepsin L (catL) in patients with primary breast cancer. PATIENTS AND METHODS CatB (n = 1,500) and catL (n = 1,391) levels were determined by enzyme-linked immunosorbent assay (ELISA) in cytosols routinely prepared from frozen-tissue samples that were submitted to our laboratory for the assessment of steroid-hormone-receptor status. The median duration of follow-up of patients still alive at the time of analysis was 93 months. RESULTS Relating catB and catL levels with classical prognostic factors, the proteases were positively correlated with the number of positive lymph nodes (P < .01), and negatively with the level of steroid-hormone receptors (P < .01). We did not find a significant relationship between catB or catL levels with age and menopausal status of the patients or with the size of the primary tumor. The levels of catB and catL were positively correlated with each other and with the rates of relapse and death (all, P < .0001). In multivariate regression analysis for relapse-free survival (RFS) and overall survival (OS), corrected for the contribution of age/menopausal status, tumor size, the number of positive lymph nodes, and steroid-hormone-receptor status, catB and catL were significant predictors of the rates of relapse and death (all, P < .01). No statistically significant interactions of catB or catL with any of the classical prognostic factors or with each other were observed in their associations with the rates of relapse and death. CONCLUSION CatB and catL levels measured in routinely prepared cytosols are strong parameters to predict the rate of relapse and the length of survival after treatment of the primary breast tumor.

pS2 in Breast Carcinoma: Association with Steroid Hormone Receptor Status

1998 ◽  
Vol 84 (6) ◽  
pp. 691-694 ◽  
Author(s):  
Dragica Nikolić-Vukosavljević ◽  
Gordana Grujić-Adanja ◽  
Radmila Janković ◽  
Mirjana Branković-Magić ◽  
Đoka Polić ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Hormone Receptor ◽  
Steroid Hormone ◽  
Hormone Receptor Status ◽  
Steroid Hormone Receptor ◽  
Receptor Status

scholarly journals TYPE OF ARTICLE: ORIGINAL ARTICLE ROLE OF CYTOKERATIN BIOMARKERS IN BREAST CARCINOMA

2016 ◽  
Vol 9 (6) ◽  
pp. 293
Author(s):  
Ritu Yadav
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Breast Carcinoma ◽  
Tumor Size ◽  
Hormone Receptor ◽  
Research Work ◽  
Tumor Grade ◽  
Lymph Node Status ◽  
Node Status ◽  
Number Of Patients

 ABSTRACT:Objective:Breast cancer comprises different biological subtypes having varied spectrum of clinical and pathological features with different prognostic and therapeutic implications. This study aimed at the identification of patients on the basis of cancer biomarkers and various clinicopathological parameters.Methods: Fresh paraffin embedded tissue block sample of three hundred fifty patients of breast carcinoma were collected during 2011-2014, from the Pathology department, Pt. B.D Sharma University of Heath Sciences Rohtak, Haryana and studied in detail to determine the correlation between hormone receptor status /cytokeratin (CK) expression along with clinicopathologicalfactors.Theimmunohistochemical assay of three hundred fifty patients of breast cancer was performed.Maximum number of patients (35%) were found in the age group of <40 years. Most of the patients were observed with the grade I (59%), tumor size 2-4.9cm (45%), <4 positive lymph node status for metastasis andinfiltrate ductal carcinoma type (93%).Triple positive and triple negative breast cancer types were studiedto identify the basal and luminal phenotypes on the basis of markers CK5, 14 and CK8/18 expression.Results:The expression of CK5 &14 was found to be significantly associated with tumor grade (P=0.001 and P=0.0001), tumor size (P= 0.001) respectively.Whereas CK8/18 expression did not reveal any significant association with tumor grade,size, lymph node status and histological type of breast carcinoma.Conclusion:In conclusion the prognostic and therapeutic value of research work would be examined and validated further on larger number of samples.Keywords: Breast carcinoma, biomarkers, clinicopathological factors, Cytokeratin, hormone receptor 

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