Single channel recording and gating function of ionic channels

1988 ◽  
Vol 44 (3) ◽  
pp. 183-188 ◽  
Author(s):  
F. Franciolini ◽  
A. Petris
Keyword(s):  
Single Channel ◽  
Ionic Channels ◽  
Single Channel Recording

Ionic channels in corneal endothelium

1996 ◽  
Vol 270 (4) ◽  
pp. C975-C989 ◽  
Author(s):  
J. L. Rae ◽  
M. A. Watsky
Keyword(s):  
Patch Clamp ◽  
Corneal Endothelium ◽  
Single Channel ◽  
Cell Voltage ◽  
Anion Channel ◽  
Ionic Channels ◽  
K Channel ◽  
Na Channel ◽  
Channel Blockers ◽  
K Currents

Single-channel patch-clamp techniques as well as standard and perforated-patch whole cell voltage-clamp techniques have been applied to the study of ionic channels in the corneal endothelium of several species. These studies have revealed two major K+ currents. One is due to an anion- and temperature-stimulated channel that is blocked by Cs+ but not by most other K+ channel blockers, and the other is similar to the family of A-currents found in excitable cells. The A-current is transient after a depolarizing voltage step and is blocked by both 4-aminopyridine and quinidine. These two currents are probably responsible for setting the -50 to -60 mV resting voltage reported for these cells. A Ca(2+)-activated ATP-inhibited nonselective cation channel and a tetrodotoxin-blocked Na+ channel are possible Na+ inflow pathways, but, given their gating properties, it is not certain that either channel works under physiological conditions. A large-conductance anion channel has also been identified by single-channel patch-clamp techniques. Single corneal endothelial cells have input resistances of 5-10 G omega and have steady-state K+ currents that are approximately 10 pA at the resting voltage. Pairs or monolayers of cells are electrically coupled and dye coupled through gap junctions.

Single-channel recording from adult Brugia malayi

2011 ◽  
Vol 11 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Alan P. Robertson ◽  
Sreekanth Puttachary ◽  
Richard J. Martin
Keyword(s):  
Single Channel ◽  
Brugia Malayi ◽  
Single Channel Recording

scholarly journals Validation of the ApneaLink™ for the Screening of Sleep Apnea: a Novel and Simple Single-Channel Recording Device

2007 ◽  
Vol 03 (04) ◽  
pp. 387-392 ◽  
Author(s):  
Milton K. Erman ◽  
Deirdre Stewart ◽  
Daniel Einhorn ◽  
Nancy Gordon ◽  
Eileen Casal
Keyword(s):  
Sleep Apnea ◽  
Single Channel ◽  
Recording Device ◽  
Single Channel Recording
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