Nitrogen and fat balances in very low birth weight infants fed human milk fortified with human milk or bovine milk protein

Fifty-one very low-birth-weight infants (birth weight <1,520 g) randomly fed either human milk or human milk supplemented with human milk protein and/or with medium-chain triglyceride (MCT) oil were observed. Plasma amino acids from these infants were studied at 2, 8, and 10 weeks. Medium-chain triglyceride oil supplementation had minimal or no influence on plasma amino acids. Human milk protein supplementation resulted in increased concentrations of all amino acids at all ages studied. The concentrations were 1.5- to threefold as compared with values in infants not given protein supplements. However, the concentrations of methionine, tyrosine, phenylalanine, and lysine remained far below values considered harmful. The age at which maximal plasma amino acid concentrations in infants given human milk protein supplementation occur coincides with the age of the lowest serum albumin concentrations in infants fed only human milk. This suggests that high plasma amino acid concentrations may hasten albumin synthesis in very low-birth-weight infants.

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THE PROTEIN TOLERANCE OF VERY LOW BIRTH WEIGHT INFANTS FED HUMAN MILK PROTEIN ENRICHED MOTHER'S MILK

Acta Paediatrica ◽

10.1111/j.1651-2227.1982.tb09481.x ◽

1982 ◽

Vol 71 (4) ◽

pp. 597-601 ◽

Cited By ~ 9

Author(s):

S. HAGELBERG ◽

B. S. LINDBLAD ◽

A. LUNDSJÖ ◽

B. CARLSSON ◽

R. FONDÉN ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Human Milk ◽

Milk Protein ◽

Very Low Birth Weight ◽

Low Birth Weight Infants ◽

Mother's Milk ◽

Mother’S Milk ◽

Human Milk Protein

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A Retrospective Analysis of the Effects of an Exclusively Human Milk Protein Diet on Neonatal Feeding Tolerance

American Journal of Perinatology ◽

10.1055/s-0040-1721374 ◽

2020 ◽

Author(s):

Jessica Wickland ◽

Christine Wade ◽

Becky Micetic ◽

Keith Meredith ◽

Gregory Martin

Keyword(s):

Birth Weight ◽

Human Milk ◽

Milk Protein ◽

Very Low Birth Weight ◽

Bovine Milk ◽

Milk Diet ◽

Vlbw Infants ◽

Key Points ◽

Human Milk Protein ◽

Feeding Tolerance

Objective This study was aimed to evaluate the effect of human milk protein fortifier (HMPF) versus bovine milk protein fortifier (BMPF) on feeding tolerance defined as the time to reach full feeds and necrotizing enterocolitis (NEC) in premature very low birth weight (VLBW) infants. Study Design A retrospective review using the BabySteps Database included 493 infants born ≤33 weeks of gestational age and ≤1,250 g (g) birth weight. A total of 218 infants fed a human milk diet (HMD) with BMPF were compared with 275 infants fed an HMD with HMPF. Results Full feeds were reached significantly sooner in the HMPF group (median: 14 vs. 16 days, p = 0.04). Weight at full feeds was significantly lower in the HMPF group (1,060 vs. 1110 g, p = 0.03). Conclusion Using HMPF to provide an exclusively HMD allowed VLBW infants to achieve full feeds sooner, but did not affect rate of NEC compared with using a BMPF with an HMD. Key Points

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