Bleomycin-kanamycin resistance as a marker of the presence of transposon Tn5 in clinical strains ofEscherichia coli

1989 ◽  
Vol 8 (11) ◽  
pp. 995-998 ◽  
Author(s):  
F. Baquero ◽  
M. A. Saldña ◽  
J. Blazquez ◽  
R. G. Palacios ◽  
J. M. Aguiar ◽  
...  
Keyword(s):  
Kanamycin Resistance ◽  
Ofescherichia Coli ◽  
Transposon Tn5 ◽  
Clinical Strains

scholarly journals Acridine treatment of F+and Hfr strains ofEscherichia coli K12carrying a neomycin-kanamycin resistance determinant

1970 ◽  
Vol 15 (3) ◽  
pp. 327-334 ◽  
Author(s):  
June N. Grindley ◽  
N. D. F. Grindley ◽  
E. S. Anderson
Keyword(s):  
Host Cell ◽  
Acridine Orange ◽  
Kanamycin Resistance ◽  
Ofescherichia Coli ◽  
Resistance Determinant ◽  
E Coli ◽  
R Factor ◽  
F Factor ◽  
Attachment Sites ◽  
No Elimination

SUMMARYThe F factor and the K resistance determinant form an R factor (KF) inE. coliK12. In this R factor the two plasmids are independent of each other and occupy different attachment sites in the host cell.Treatment of an F+(K) strain with acriflavine and acridine orange yielded the following classes: F+K−; F−K+; and F−K−. The K determinant was thus curable independently of F, which supports the hypothesis of independence of the two plasmids. In Hfr(K) strains, K remains curable with acridines while F is immune. Thus, K remains independent of F in both the F+and Hfr states.The use of higher concentrations of acridine orange than those needed for cure of K in the F+(K) strain resulted in no elimination of K, although the F factor was absent from all surviving lines tested. It is suggested that this is caused by equal inhibition of replication of both the chromosome and K, and greater inhibition of that of F.

scholarly journals Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains ofEscherichia coli

2015 ◽  
Vol 291 (6) ◽  
pp. 2837-2847 ◽  
Author(s):  
Harsha Bajaj ◽  
Mariano A. Scorciapino ◽  
Lucile Moynié ◽  
Malcolm G. P. Page ◽  
James H. Naismith ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Ofescherichia Coli ◽  
Clinical Strains

Morphologic alterations in bacteroides fragilis following single and combinant beta-lactam exposure

1986 ◽  
Vol 44 ◽  
pp. 304-305
Author(s):  
Michael P. Goheen ◽  
Charles E. Edmiston
Keyword(s):  
Bacteroides Fragilis ◽  
Synergistic Activity ◽  
Beta Lactam ◽  
Clinical Strains ◽  
Drug Activity ◽  
Obligate Anaerobic ◽  
Morphologic Changes

The synergistic activity of antimicrobial combinants against aerobic and facultative microorganisms has been well documented. in comparison, few studies have been performed using obligate anaerobic isolates and antimicrobial combinants. For this study clinical strains of Bacteroides fragilis(BF) were selected to investigate both single/combinant drug activity and cellular morphologic changes when BF is exposed to Imipenem (I), Piperacillin (P), Cefpimizole (C), Imipenem/Piperacillin (I+P), and Imipenem/Cefpimizole (I+C).

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