Immunoprecipitation of a pertussis toxin substrate of the Go family from rat islets of Langerhans
Keyword(s):
Rat islets express a pertussis toxin sensitive G-protein involved in receptor-mediated inhibition of insulin secretion. This has been assumed previously to represent “Gi” which couples inhibitory receptors to adenylate cyclase. Incubation of islet G-proteins with32P-NAD and pertussis toxin resulted in the labelling of a band of molecular weight 40,000. This band was very broad and did not allow resolution of individual components. Incubation of the radiolabelled proteins with an anti-Go antiserum resulted in specific immunoprecipitation of a32P-labelled band. These results demonstrate that the complement of pertussis toxin sensitive G-proteins in rat islets includes Go.
1992 ◽
Vol 8
(2)
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pp. 103-108
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1973 ◽
Vol 320
(1)
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pp. 44-52
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1999 ◽
Vol 148
(1-2)
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pp. 29-35
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1992 ◽
Vol 43
(8)
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pp. 1859-1864
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1993 ◽
Vol 1176
(1-2)
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pp. 64-68
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