Noninvasive acceleration measurements to characterize knee arthritis and chondromalacia

1995 ◽  
Vol 23 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Narender P. Reddy ◽  
Bruce M. Rothschild ◽  
Mita Mandal ◽  
Vineet Gupta ◽  
Srikanth Suryanarayanan
Keyword(s):  
Knee Arthritis

Apportionment of Impairment from Meniscal Tears and Knee Arthritis

2013 ◽  
Vol 18 (5) ◽  
pp. 1-10 ◽  
Author(s):  
Charles N. Brooks ◽  
James B. Talmage
Keyword(s):  
Medial Meniscus ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Detailed Knowledge ◽  
Meniscal Tears ◽  
Knee Arthritis ◽  
Degenerative Arthritis ◽  
Study Results ◽  
Physical Findings ◽  
Causation Analysis

Abstract Meniscal tears and osteoarthritis (osteoarthrosis, degenerative arthritis, or degenerative joint disease) are two of the most common conditions involving the knee. This article includes definitions of apportionment and causes; presents a case report of initial and recurrent tears of the medial meniscus plus osteoarthritis (OA) in the medial compartment of the knee; and addresses questions regarding apportionment. The authors, experienced impairment raters who are knowledgeable regarding the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), show that, when instructions on impairment rating are incomplete, unclear, or inconsistent, interrater reliability diminishes (different physicians may derive different impairment estimates). Accurate apportionment of impairment is a demanding task that requires detailed knowledge of causation for the conditions in question; the mechanisms of injury or extent of exposures; prior and current symptoms, functional status, physical findings, and clinical study results; and use of the appropriate edition of the AMA Guides. Sometimes the available data are incomplete, requiring the rating physician to make assumptions. However, if those assumptions are reasonable and consistent with the medical literature and facts of the case, if the causation analysis is plausible, and if the examiner follows impairment rating instructions in the AMA Guides (or at least uses a rational and hence defensible method when instructions are suboptimal), the resulting apportionment should be credible.

Early Knee Arthritis: The Role of Arthroscopy: Beneficial or Placebo?

Orthopedics ◽  
2003 ◽  
Vol 26 (9) ◽  
pp. 943-944
Author(s):  
W Norman Scott ◽  
Henry D Clarke
Keyword(s):  
Knee Arthritis

Ligustrazine Reduces the Apoptosis of Synovial Cells in Knee Arthritis Rats by Inhibiting the Expression of Glucose Regulatory Protein 78 and CCAAT Enhancer Binding Protein Beta (C/EBPb)

2021 ◽  
Vol 13 (8) ◽  
pp. 1467-1473
Author(s):  
Housen Jiang ◽  
Kun Zhang ◽  
Liming Zhao ◽  
Yan Li
Keyword(s):  
Synovial Tissue ◽  
Regulatory Protein ◽  
Cartilage Tissue ◽  
Synovial Cells ◽  
Mankin Score ◽  
Vegf Mrna ◽  
Knee Arthritis ◽  
Healthy Group ◽  
Group 2 ◽  
Severity Of The Disease

To investigate the effect of Ligustrazine on synovial cells and expression of GRP78 and C/EBPb in knee arthritis rats, 52 healthy SD rats, aged 10-15 months, weighing 185–225 g, were selected and fed routinely. According to the principle of random distribution, the experimental rats were assigned into healthy group, arthritis group, ligustrazine 1 and 2 groups, with 13 rats in each group. HE staining was used to detect the pathological morphology. Mankin score was used to measure the severity of the disease. The apoptosis of synovial cells was assessed by flow cytometry. col2α1 and VEGF levels were detected by RT-PCR and GRP78, XBP1 and C/EBP β levels were detected by Western blot. In the healthy group, the cells were scattered orderly, the cartilage surface was smooth, and the synovial tissue was not damaged; in the arthritis group, the joint tissue was damaged, the synovial tissue proliferated and degenerated, the cells were disordered, and synovial pannus was produced; in Ligustrazine group 1 and Ligustrazine 2 groups had certain improvement, and the effect to Ligustrazine group 2 was more obvious. Mankin score of healthy group was lower than arthritis group (P < 0.05) which had higher Mankin score than Ligustrazine 1 and 2 groups, and the Mankin score of Ligustrazine 2 group was lower than that of Ligustrazine 1 group (P < 0.05). Synovial cells apoptosis in healthy group was lower than arthritis group (P < 0.05) which had higher apoptosis than Ligustrazine 1 group and ligustrazine 2 group (P < 0.05) with lower apoptosis for Ligustrazine 2 group (P < 0.05). The expressions of col2α1 mRNA and VEGF mRNA in healthy group were lower than arthritis group (P < 0.05) which had higher levels than Ligustrazine 1 and 2 groups with Ligustrazine 2 group showing more obvious effects (P < 0.05). Arthritis group had significantly elevated levels of GRP78 and XBP1 and decreased C/EBP β levels (P < 0.05). However, GRP78 and XBP1 levels in TMP-1 group and tmp-2 group were decreased and C/EBP β level was increased (P < 0.05). In a word, Ligustrazine can reduce the apoptosis of synovial cells, promote the repair of cartilage tissue and improve the condition of knee arthritis rats by regulating the expression level of GRP78 and XBP1.

scholarly journals Adipose Derived-Mesenchymal Stem Cells Viability and Differentiating Features for Orthopaedic Reparative Applications: Banking of Adipose Tissue

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Ilaria Roato ◽  
Daniela Alotto ◽  
Dimas Carolina Belisario ◽  
Stefania Casarin ◽  
Mara Fumagalli ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Articular Cartilage ◽  
Tissue Banking ◽  
Stromal Vascular Fraction ◽  
Single Infusion ◽  
Knee Arthritis ◽  
Symptomatic Knee

Osteoarthritis is characterized by loss of articular cartilage also due to reduced chondrogenic activity of mesenchymal stem cells (MSCs) from patients. Adipose tissue is an attractive source of MSCs (ATD-MSCs), representing an effective tool for reparative medicine, particularly for treatment of osteoarthritis, due to their chondrogenic and osteogenic differentiation capability. The treatment of symptomatic knee arthritis with ATD-MSCs proved effective with a single infusion, but multiple infusions could be also more efficacious. Here we studied some crucial aspects of adipose tissue banking procedures, evaluating ATD-MSCs viability, and differentiation capability after cryopreservation, to guarantee the quality of the tissue for multiple infusions. We reported that the presence of local anesthetic during lipoaspiration negatively affects cell viability of cryopreserved adipose tissue and cell growth of ATD-MSCs in culture. We observed that DMSO guarantees a faster growth of ATD-MSCs in culture than trehalose. At last, ATD-MSCs derived from fresh and cryopreserved samples at −80°C and −196°C showed viability and differentiation ability comparable to fresh samples. These data indicate that cryopreservation of adipose tissue at −80°C and −196°C is equivalent and preserves the content of ATD-MSCs in Stromal Vascular Fraction (SVF), guaranteeing the differentiation ability of ATD-MSCs.

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