Increasing role of prostate specific antigen (PSA) in the clinical staging of prostate cancer patients

1993 ◽  
Vol 25 (1) ◽  
pp. 4-7
Author(s):  
A. M. Sassine ◽  
C. Schulman
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Clinical Staging

Tissue Polypeptide-Specific Antigen (Tps) Immunoassay in the Diagnosis and Clinical Staging of Prostatic Carcinoma. Comparison with Prostate-Specific Antigen (Psa)

1997 ◽  
Vol 12 (1) ◽  
pp. 27-34 ◽  
Author(s):  
L. Ceriani ◽  
L. Giovanella ◽  
M. Salvadore ◽  
A.V. Bono ◽  
G. Roncari
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Roc Curve ◽  
Specific Antigen ◽  
Benign Prostatic Hypertrophy ◽  
Clinical Staging ◽  
Control Group ◽  
Roc Curve Analysis ◽  
Skeletal Involvement

This experimental study investigated the potential role of Tissue Polypeptide-Specific Antigen (TPS) in comparison with Prostate-Specific Antigen (PSA) in the diagnosis and the clinical and pathological staging of prostate cancer. Serum TPS and PSA levels were determined in 128 patients (pts) with benign prostatic hypertrophy (BPH; Group 1) and in 92 pts with prostate cancer (Group 2). TPS was also measured in a control group of 100 healthy subjects. Normal cutoff values of 85 U/l for TPS and 4 ng/ml for PSA were determined on the basis of ROC curve analysis. The sensitivity, specificity and accuracy in the diagnosis of prostate cancer were 49%, 95% and 76% for TPS, and 84%, 90% and 87% for PSA. The combination of the two markers provided a higher accuracy (88%), improving the sensitivity of PSA, since 47% of patients with normal PSA had pathological levels of TPS. TPS showed an increase in sensitivity from low to higher stages of disease and, in patients with skeletal involvement, from small to larger numbers of bone metastases (Kruskal Wallis p < 0.0001). Nevertheless, TPS serum levels are not useful in the clinical staging of prostate cancer as they have a poorer performance than PSA. TPS was ineffective (ROC curve area=0.68) in predicting extraprostatic disease and demonstrated a reduced ability (area = 0.78) to identify skeletal involvement. Moreover, the combination of the two markers did not significantly improve the performance of PSA alone. The serum concentration of TPS in patients with localized tumors was not related to the degree of tumor cell differentiation evaluated by the Gleason score. Conclusion Our preliminary experience suggests that TPS in association with PSA may be useful at the time of diagnosis of prostate cancer. However, these preliminary data have to be confirmed by larger clinical trials and the role of this association in the clinical setting needs to be analyzed with an adequate evaluation of the cost-effectiveness ratio.

The role of PSMA PET/CT imaging in restaging of prostate cancer patients with low prostate-specific antigen levels

2017 ◽  
Vol 38 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Levent Kabasakal ◽  
Emre Demirci ◽  
Jamal Nematyazar ◽  
Reşit Akyel ◽  
Baresh Razavi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Ct Imaging ◽  
Psma Pet ◽  
Pet Ct
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