scholarly journals Nadir Prostate-Specific Antigen After Neoadjuvant Androgen Suppression (AS) in Prostate Cancer Patients Receiving Short-term AS and Radiation Therapy: Pooled Analysis of Four NRG Oncology/RTOG Randomized Clinical Trials

2015 ◽  
Vol 93 (3) ◽  
pp. S46
Author(s):  
C.L. Hallemeier ◽  
P. Zhang ◽  
T.M. Pisansky ◽  
G.E. Hanks ◽  
D.G. McGowan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Trials ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Randomized Clinical Trials ◽  
Specific Antigen ◽  
Pooled Analysis ◽  
Short Term ◽  
Androgen Suppression

scholarly journals Influence of body mass index on prostate-specific antigen failure after androgen suppression and radiation therapy for localized prostate cancer

Cancer ◽  
2007 ◽  
Vol 109 (8) ◽  
pp. 1493-1498 ◽  
Author(s):  
Jason A. Efstathiou ◽  
Ming-Hui Chen ◽  
Andrew A. Renshaw ◽  
Marian J. Loffredo ◽  
Anthony V. D'Amico
Keyword(s):  
Prostate Cancer ◽  
Body Mass Index ◽  
Radiation Therapy ◽  
Prostate Specific Antigen ◽  
Body Mass ◽  
Specific Antigen ◽  
Localized Prostate Cancer ◽  
Androgen Suppression

Six-Month Androgen Suppression Plus Radiation Therapy Compared With Radiation Therapy Alone for Men With Prostate Cancer and a Rapidly Increasing Pretreatment Prostate-Specific Antigen Level

2006 ◽  
Vol 24 (25) ◽  
pp. 4190-4195 ◽  
Author(s):  
Anthony V. D'Amico ◽  
Marian Loffredo ◽  
Andrew A. Renshaw ◽  
Brittany Loffredo ◽  
Ming-Hui Chen
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Prostate Specific Antigen ◽  
Cox Regression ◽  
Locally Advanced ◽  
Specific Antigen ◽  
Study Cohort ◽  
Psa Recurrence ◽  
Psa Velocity ◽  
Androgen Suppression

PurposeWe evaluated whether treatment with 6 months of androgen-suppression therapy (AST) and radiation therapy (RT) compared with RT was associated with the time to prostate-specific antigen (PSA) recurrence, prostate cancer–specific mortality (PCSM), and all-cause mortality (ACM) in men with a pretreatment PSA velocity more than 2 ng/mL/yr.Patients and MethodsThe study cohort comprised 241 men with clinically localized or locally advanced prostate cancer treated with RT and AST or RT from 1989 to 2002. Cox regression and Gray's formulation were used to assess whether treatment was associated significantly with the time to PSA recurrence or ACM and PCSM, respectively, adjusting for known prognostic factors.ResultsDespite the significantly longer median follow-up, younger age at diagnosis, higher proportion of Gleason score 7 to 10, and advanced T-category cancers, significantly lower estimates of PSA recurrence (P < .001), PCSM (P = .007), and ACM (P < .001) were observed in men who were treated using RT and AST compared with RT. Treatment with RT and AST compared with RT was associated with a longer time to PSA recurrence (adjusted hazard ratio [HR], 0.22; 95% CI, 0.14 to 0.35; P < .001), PCSM (HR, 0.23, 95% CI, 0.09 to 0.64; P = .005), and ACM (HR, 0.30; 95% CI, 0.16 to 0.58; P < .001).ConclusionTreatment using 6 months of AST and RT compared with RT in men with a pretreatment PSA velocity greater than 2 ng/mL/yr was associated with a longer time to PSA recurrence, PCSM, and ACM.

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