Prevalence of antibodies against respiratory viruses (parainfluenza virus type 3, respiratory syncytial virus, reovirus and adenovirus) in relation to productivity in Syrian Awassi sheep

SUMMARYSurveys for respiratory virus antibodies in the Jamaican population have shown that adenovirus, respiratory syncytial virus and parainfluenza types 1 and 3 virus antibodies are acquired early in life. The incidence of haemagglutination-inhibiting antibodies to parainfluonza viruses increases rapidly with age and almost all adults possess parainfluenza type 3 antibody, usually in high titre. Parainfluenza type 1 antibodies are only slightly less common. Complement-fixing antibodies to the adenovirus group were also observed to increase in incidence with age.Complement-fixing antibody to respiratory syncytial virus was less common in Jamaican sera than antibody to the other respiratory viruses described here. The highest titres were observed in the youngest age-group.

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A Prototype Recombinant Vaccine Against Respiratory Syncytial Virus and Parainfluenza Virus Type 3

Nature Biotechnology ◽

10.1038/nbt0894-813 ◽

1994 ◽

Vol 12 (8) ◽

pp. 813-818 ◽

Cited By ~ 10

Author(s):

Run-Pan Du ◽

Gail E. D. Jackson ◽

Philip R. Wyde ◽

Wei-Yao Yan ◽

Qijun Wang ◽

...

Keyword(s):

Respiratory Syncytial Virus ◽

Virus Type ◽

Recombinant Vaccine ◽

Parainfluenza Virus ◽

Syncytial Virus ◽

Type 3

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Recombinant Bovine/Human Parainfluenza Virus Type 3 (B/HPIV3) Expressing the Respiratory Syncytial Virus (RSV) G and F Proteins Can Be Used To Achieve Simultaneous Mucosal Immunization against RSV and HPIV3

Journal of Virology ◽

10.1128/jvi.75.10.4594-4603.2001 ◽

2001 ◽

Vol 75 (10) ◽

pp. 4594-4603 ◽

Cited By ~ 71

Author(s):

Alexander C. Schmidt ◽

Josephine M. McAuliffe ◽

Brian R. Murphy ◽

Peter L. Collins

Keyword(s):

Respiratory Syncytial Virus ◽

Respiratory Tract ◽

Host Range ◽

Virus Type ◽

Serum Antibody ◽

Parainfluenza Virus ◽

Range Restriction ◽

Syncytial Virus ◽

Human Parainfluenza Virus ◽

Type 3

ABSTRACT Recombinant bovine/human parainfluenza virus type 3 (rB/HPIV3), a recombinant bovine PIV3 (rBPIV3) in which the F and HN genes were replaced with their HPIV3 counterparts, was used to express the major protective antigens of respiratory syncytial virus (RSV) in order to create a bivalent mucosal vaccine against RSV and HPIV3. The attenuation of rB/HPIV3 is provided by the host range restriction of the BPIV3 backbone in primates. RSV G and F open reading frames (ORFs) were placed under the control of PIV3 transcription signals and inserted individually into the rB/HPIV3 genome in the promoter-proximal position preceding the nucleocapsid protein gene. The recombinant PIV3 expressing the RSV G ORF (rB/HPIV3-G1) was not restricted in its replication in vitro, whereas the virus expressing the RSV F ORF (rB/HPIV3-F1) was eightfold restricted compared to its rB/HPIV3 parent. Both viruses replicated efficiently in the respiratory tract of hamsters, and each induced RSV serum antibody titers similar to those induced by RSV infection and anti-HPIV3 titers similar to those induced by HPIV3 infection. Immunization of hamsters with rB/HPIV3-G1, rB/HPIV3-F1, or a combination of both viruses resulted in a high level of resistance to challenge with RSV or HPIV3 28 days later. These results describe a vaccine strategy that obviates the technical challenges associated with a live attenuated RSV vaccine, providing, against the two leading viral agents of pediatric respiratory tract disease, a bivalent vaccine whose attenuation phenotype is based on the extensive host range sequence differences of BPIV3.

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Infection and maturation of monocyte-derived human dendritic cells by human respiratory syncytial virus, human metapneumovirus, and human parainfluenza virus type 3

Virology ◽

10.1016/j.virol.2008.11.043 ◽

2009 ◽

Vol 385 (1) ◽

pp. 169-182 ◽

Cited By ~ 46

Author(s):

Cyril Le Nouën ◽

Shirin Munir ◽

Stéphanie Losq ◽

Christine C. Winter ◽

Thomas McCarty ◽

...

Keyword(s):

Dendritic Cells ◽

Respiratory Syncytial Virus ◽

Virus Type ◽

Human Metapneumovirus ◽

Human Respiratory Syncytial Virus ◽

Parainfluenza Virus ◽

Syncytial Virus ◽

Human Dendritic Cells ◽

Human Parainfluenza Virus ◽

Type 3

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Virus isolations from patients in general practice, 1961–71

Journal of Hygiene ◽

10.1017/s0022172400023469 ◽

1974 ◽

Vol 72 (2) ◽

pp. 255-264 ◽

Cited By ~ 4

Author(s):

P. G. Higgins

Keyword(s):

Respiratory Syncytial Virus ◽

Virus Type ◽

Mumps Virus ◽

Influenza Viruses ◽

Parainfluenza Virus ◽

Parainfluenza Viruses ◽

Syncytial Virus ◽

Simplex Virus ◽

Type 3

SUMMARYDuring the period 1961–71 of 1785 viruses isolated from patients in the general population 503 (28%) were rhinoviruses, 465 (26%) influenza viruses, 248 (14%) enteroviruses, 234 (13%) herpes simplex virus, 132 (7%) parainfluenza viruses, 129 (7%) adenoviruses and 49 (3%) respiratory syncytial virus. Also isolated were 18 strains of mumps virus, 7 coronaviruses and 295 streptococci of groups A, C or G.Fluctuations were observed in the frequency with which respiratory syncytial virus, parainfluenza virus type 2, and the adenoviruses were isolated over the 10-year period.Influenza viruses types A and B, parainfluenza viruses types 1 and 2, respiratory syncytial virus, adenoviruses types 3, 4, 6, 7 and 21, and many enteroviruses were all associated with outbreaks.Infections with influenza viruses A and B and parainfluenza viruses types 1 and 2 came during the winter, whereas those with parainfluenza virus type 3, enteroviruses, and rhinoviruses were more frequently seen in the summer and early autumn.

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