Pancreatic islet-cell viability, functionality and oxidative status remain unaffected at pharmacological concentrations of commonly used antibioticsin vitro

2001 ◽  
Vol 26 (3) ◽  
pp. 349-355 ◽  
Author(s):  
Yogita Shewade ◽  
Suraj Tirth ◽  
R. R. Bhonde
Keyword(s):  
Cell Viability ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Oxidative Status ◽  
Pancreatic Islet Cell

scholarly journals Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Xing Yu Li ◽  
Po Sing Leung
Keyword(s):  
Cell Death ◽  
Cell Viability ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Diabetic Patients ◽  
Dependent Manner ◽  
Pancreatic Islet Cell ◽  
Human Pancreatic Islet ◽  
Cell Clusters ◽  
And Function

AbstractFerroptosis is a newly identified and novel form of cell death, which is characterized by an iron- and reactive oxygen species (ROS)-dependent manner. Potential utility of ferroptotic cell death has been recently proposed for cancer treatment. Meanwhile, ROS generation and apoptosis are inherently consequent to cell apoptosis and dysfunction during islet cell preparation and transplantation. Whether ferroptosis induction is a regulator for cell viability and function in human pancreatic islet-cell clusters (ICCs) derived from pancreatic progenitor cells (PPCs) remains elusive. We thus sought to induce ferroptosis in our established cell culture system of human PPCs/ICCs, examine the effects of ferroptosis on ICCs, and explore the potential regulatory pathways involved. Our results showed that ICCs were prone to the use of ferroptosis-inducing and inhibiting agents under our culture conditions. Erastin, a ferroptosis inducer, was found to trigger ferroptosis in ICCs, without the apparent detection of other types of cell death involved, such as apoptosis and autophagy. In corroboration, the use of ferroptosis inhibitor, ferrostatin-1 (Fer-1), was found to enhance the cell viability of ICCs and prevent them from ferroptosis as well as improve its function. Mechanistically, the erastin-induced ferroptosis in ICCs was probably mediated via activation of JNK/P38/MAPK pathways and upregulation of NOX4 expression. Together, our findings may provide a scientific basis of ferroptosis inhibition as a potential for the amelioration of ICC survival and functionality during islet transplantation in diabetic patients.

333-LB: Impact of Aging on Mitochondrial Respiratory Chain Expression and Pancreatic Islet Cell Composition by Using a Mitochondrial DNA Mutator Mouse Model

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 333-LB
Author(s):  
XUEFEI YU ◽  
CATHERINE ARDEN ◽  
CHUN CHEN ◽  
CARLA BRADSHAW ◽  
JULIA WHITEHALL ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mouse Model ◽  
Respiratory Chain ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Mitochondrial Respiratory Chain ◽  
Pancreatic Islet Cell ◽  
Cell Composition ◽  
Mitochondrial Respiratory

Islet-on-a-chip: Biomimetic micropillar-based microfluidic system for three-dimensional pancreatic islet cell culture

2021 ◽  
Vol 183 ◽  
pp. 113215
Author(s):  
Patrycja Sokolowska ◽  
Kamil Zukowski ◽  
Justyna Janikiewicz ◽  
Elzbieta Jastrzebska ◽  
Agnieszka Dobrzyn ◽  
...  
Keyword(s):  
Cell Culture ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Three Dimensional ◽  
Microfluidic System ◽  
Pancreatic Islet Cell ◽  
Islet Cell Culture

Diarrhea associated with pancreatic islet-cell tumors

1964 ◽  
Vol 9 (2) ◽  
pp. 97-108 ◽  
Author(s):  
Julien Deleu ◽  
Hendrik Tytgat ◽  
Guy E. Goidsenhoven
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Tumors ◽  
Pancreatic Islet Cell ◽  
Pancreatic Islet Cell Tumors

scholarly journals Non-Islet Origin of Pancreatic Islet Cell Tumors

2004 ◽  
Vol 89 (4) ◽  
pp. 1934-1938 ◽  
Author(s):  
Alexander O. Vortmeyer ◽  
Steve Huang ◽  
Irina Lubensky ◽  
Zhengping Zhuang
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Tumors ◽  
Pancreatic Islet Cell ◽  
Pancreatic Islet Cell Tumors

Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk

2021 ◽  
Author(s):  
Joshua Chiou ◽  
Chun Zeng ◽  
Zhang Cheng ◽  
Jee Yun Han ◽  
Michael Schlichting ◽  
...  
Keyword(s):  
Single Cell ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Chromatin Accessibility ◽  
Diabetes Risk ◽  
Cell Type ◽  
Pancreatic Islet Cell
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