A case of small bowel carcinoma in Crohn’s disease

1991 ◽  
Vol 26 (4) ◽  
pp. 514-522 ◽  
Author(s):  
Makoto Watanabe ◽  
Hiroshi Nakano ◽  
Eiko Takano ◽  
Ikuro Miyachi ◽  
Madoka Ito ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Small Bowel Carcinoma

scholarly journals A Case of Small Bowel Carcinoma with Crohn's Disease

2008 ◽  
Vol 41 (3) ◽  
pp. 329-334 ◽  
Author(s):  
Koya Hida ◽  
Junichiro Kawamura ◽  
Satoshi Nagayama ◽  
Takaki Sakurai ◽  
Yoshinori Mizumoto ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Small Bowel Carcinoma

scholarly journals Separation of Low- Versus High-grade Crohn’s Disease-associated Small Bowel Carcinomas is Improved by Invasive Front Prognostic Marker Analysis

2019 ◽  
Vol 14 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Giovanni Arpa ◽  
Federica Grillo ◽  
Paolo Giuffrida ◽  
Gabriella Nesi ◽  
Catherine Klersy ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Stage I ◽  
Low Grade ◽  
Invasive Front ◽  
Poorly Differentiated Clusters ◽  
Small Bowel Carcinoma ◽  
Poorly Differentiated ◽  
Tumour Budding

Abstract Background and Aims Crohn’s disease-associated small bowel carcinoma is a rare event, usually reported to have a severe prognosis. However, in previous investigations we have found a minority of cases displaying a relatively favourable behaviour, thus outlining the need to improve the histopathological prediction of Crohn’s disease-associated small bowel carcinoma prognosis. Methods As in recent studies on colorectal cancer, a substantial improvement in prognostic evaluations has been provided by the histological analysis of the tumour invasive front; we therefore systematically analysed the tumour budding and poorly differentiated clusters in the invasive front of 47 Crohn’s disease-associated small bowel carcinomas collected through the Small Bowel Cancer Italian Consortium. Results Both tumour budding and poorly differentiated cluster analyses proved highly effective in prognostic evaluation of Crohn’s disease-associated small bowel carcinomas. In addition, they retained prognostic value when combined with two other parameters, i.e. glandular histology and stage I/II, both known to predict a relatively favourable small bowel carcinoma behaviour. In particular, association of tumour budding and poorly differentiated clusters in a combined invasive front score allowed identification of a minor subset of cancers [12/47, 25%] characterised by combined invasive front low grade coupled with a glandular histology and a low stage [I or II] and showing no cancer-related death during a median follow-up of 73.5 months. Conclusions The improved distinction of lower- from higher-grade Crohn’s disease-associated small bowel carcinomas provided by invasive front analysis should be of potential help in choosing appropriate therapy for these rare and frequently ominous neoplasms.

Serrated epithelial lesion with dysplasia as a precursor to small bowel carcinoma associated with Crohn's disease

2021 ◽  
Vol 44 (7) ◽  
pp. 489-490
Author(s):  
Míriam Gené ◽  
Anna Alguersuari ◽  
Francesc Pons ◽  
Carla Miñambres ◽  
Eva Musulén
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Small Bowel Carcinoma ◽  
Epithelial Lesion

scholarly journals Small bowel carcinoma mimicking a relapse of Crohn's disease: A case series

2011 ◽  
Vol 5 (2) ◽  
pp. 152-156 ◽  
Author(s):  
J.E. Baars ◽  
J.C. Thijs ◽  
D.J. Bac ◽  
P.C.J. ter Borg ◽  
E.J. Kuipers ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Case Series ◽  
Small Bowel Carcinoma

scholarly journals Prognostic relevance and putative histogenetic role of cytokeratin 7 and MUC5AC expression in Crohn’s disease-associated small bowel carcinoma

2021 ◽  
Author(s):  
Giovanni Arpa ◽  
Alessandro Vanoli ◽  
Federica Grillo ◽  
Roberto Fiocca ◽  
Catherine Klersy ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Prognostic Factors ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Patient Survival ◽  
Precancerous Lesions ◽  
Cytokeratin 7 ◽  
Ileal Mucosa ◽  
Small Bowel Carcinoma ◽  
Multivariable Analyses

AbstractMost Crohn’s disease-associated small bowel carcinomas (CrD-SBCs) are diagnosed in advanced stage and have poor prognosis. To improve diagnosis and therapy, a better knowledge of tumour precancerous lesions, histotypes and prognostic factors is needed. We investigated histologically and immunohistochemically 52 CrD-SBCs and 51 small bowel carcinomas unrelated to inflammatory disease, together with their tumour-associated mucosa, looking for Crohn-selective changes. Histologic patterns and phenotypic markers potentially predictive of CrD-SBC histogenesis and prognosis were analysed. Cytokeratin 7 or MUC5AC-positive metaplastic changes were found in about half of investigated CrD-SBCs, significantly more frequently than in CrD-unrelated SBCs. They correlated with metaplastic changes of their associated mucosa, while being absent in normal ileal mucosa. Histologic patterns suggestive for progression of some cytokeratin 7 and/or MUC5AC-positive metaplastic lesions into cancer of the same phenotype were also observed. Patient survival analyses showed that tumour cytokeratin 7 or MUC5AC expression and non-cohesive histotype were adverse prognostic factors at univariable analysis, while cytokeratin 7 and non-cohesive histotype were also found to predict worse survival in stage- and age-inclusive multivariable analyses. Besides conventional dysplasia, hyperplasia-like non-conventional lesions were observed in CrD-SBC-associated mucosa, with patterns suggestive for a histogenetic link with adjacent cancer. In conclusion the cytokeratin 7 and/or MUC5AC-positive metaplastic foci and the non-conventional growths may have a role in cancer histogenesis, while tumour cytokeratin 7 and non-cohesive histotype may also predict poor patient survival. Present findings are worth being considered in future prospective histogenetic and clinical studies.

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